The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cadmium-Free CuInS2/ZnS Quantum Dots for Sentinel Lymph Node Imaging with Reduced Toxicity
Abstract
Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, the toxicity of the components of NIR emitting II-VI and IV-VI QDs that have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to the clinical use of QDs. Here, we present the synthesis of CuInS(2)/ZnS core/shell QDs emitting in the NIR ( approximately 800 nm) with good quantum yield and stability even after transfer into water. We demonstrate the potential of these QDs by imaging two regional lymph nodes (LNs) in vivo in mice. We then compare the inflammatory response of the axillary LN induced by different doses of CuInS(2)/ZnS and CdTeSe/CdZnS QDs and show a clear difference in acute local toxicity, the onset of inflammation only occurring at a 10 times more concentrated dose for CuInS(2)/ZnS QDs than for their Cd-containing counterparts.
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Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Cited by
Copper Selenide Nanocrystals for Photothermal Therapy
Hessel, C. M., Pattani, V. P., Rasch, M., Panthani, M. G., Koo, B., Tunnell, J. W., & Korgel, B. A. (2011) · Nano Letters · doi:10.1021/nl201400z · Cited by 1,451
Quantum dots in biomedical applications
Wagner, A. M., Knipe, J. M., Orive, G., & Peppas, N. A. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.022 · Cited by 632
New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine
Xu, G., Zeng, S., Zhang, B., Swihart, M. T., Yong, K.-T., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00290 · Cited by 587
Optoelectronic Properties of CuInS2 Nanocrystals and Their Origin
Leach, A. D. P., & Macdonald, J. E. (2016) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.5b02211 · Cited by 266
Metadata
- Authors
- Pons, T., Pic, E., Lequeux, N., Cassette, E., Bezdetnaya, L., Guillemin, F., Marchal, F., & Dubertret, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-04-13
- Volume
- 4
- Issue
- 5
- Pages
- 2531-2538
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1973722757
- Cited by
- 533
- References
- 1
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- closed
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