Interiotherins C and D, Two New Lignans from Kadsura interior and Antitumor-Promoting Effects of Related Neolignans on Epstein−Barr Virus Activation
Abstract
Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
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Several studies reported that some lignans (gomisin A, gomisin G, schizandrin, and schisanhenol) possess antitumor bioactivities.
“Several studies reported that some lignans (gomisin A, gomisin G, schizandrin, and schisanhenol) possess antitumor bioactivities [94,95,96,97,98].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [94]
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Analysis of Schisandra chinensis and Schisandra sphenanthera
Lu, Y., & Chen, D.-F. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.09.070 · Cited by 249 · see citing works
Self-citationPlant Adaptogens—History and Future Perspectives
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- Authors
- Chen, D.-F., Zhang, S.-X., Kozuka, M., Sun, Q.-Z., Feng, J., Wang, Q., Mukainaka, T., Nobukuni, Y., Tokuda, H., Nishino, H., Wang, H.-K., Morris-Natschke, S. L., & Lee, K.-H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Chen, Dao-Feng
- Lee, Kuo-Hsiung
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-07-20
- Volume
- 65
- Issue
- 9
- Pages
- 1242-1245
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2075816870
- Cited by
- 86
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 9 · 2012: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
- Health Sciences › Medicine › Rehabilitation › Magnolia and Illicium research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- lignans, neolignans, chemoprevention, Epstein-Barr virus, schisandrin C, structure elucidation, stereochemistry, natural product isolation
- MeSH terms
- Antineoplastic Agents, Phytogenic, Antiviral Agents, China, Circular Dichroism, Dioxoles, Herpesvirus 4, Human, Lymphocytes, Molecular Conformation, Plants, Medicinal, Tumor Cells, Cultured, Virus Replication, Molecular Structure, Lignans, Plant Stems, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, Kadsura, Cyclooctanes
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