Cited by 20Plant-derived Lignans Synthesis and BioactivityPhytochemistry and Biological ActivitiesMagnolia and Illicium research

New Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of Schisandra chinensis

Yang, Bing‐You, Guo, Jiang‐Tao, Li, Zu‐Yi, Wang, Chang‐Fu, Wang, Zhi‐Bin, Wang, Qiu‐Hong, Kuang, Hai‐Xue·2016·Chemistry & Biodiversity

Abstract

Three new lignans (1 – 3), together with four new thymoquinol glycosides (4 – 7), were isolated from 70%‐EtOH extract of the rattan stems of Schisandra chinensis. The structures of 1 – 7 were elucidated by detailed spectroscopic analyses, and these new compounds were identified as pinobatol‐9‐O‐β‐d‐glucopyranoside (1), 1,2,13,14‐tetramethoxydibenzocyclooctadiene 3,12‐O‐β‐d‐diglucopyranoside (2), 3,7‐dihydroxy‐1,2,13,14‐tetramethoxydibenzocyclooctadiene 12‐O‐β‐d‐glucopyranoside (3), thymoquinol 2‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (4), thymoquinol 2‐O‐α‐d‐arabinofuranosyl‐(1→6)‐β‐d‐glucopyranoside (5), thymoquinol 5‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (6), and thymoquinol 5‐O‐α‐d‐arabinofuranosyl‐(1→6)‐β‐d‐glucopyranoside (7). The neuroprotective activity of 1 – 7 was evaluated on PC12 cells with neurotoxicity induced by amyloid‐beta 1 – 42 (Aβ1 – 42). Compounds 2 and 3 showed protecting activity against Aβ‐induced toxicity in PC12 cells.

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Crossref · 10.1002/cbdv.201500311

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  • All phytochemicals determined beneficial effects such as cytotoxic, antioxidant, neuroprotective, hepatoprotective, increased physical strength, stress-protective, and anti-inflammatory.

    “All of phytochemicals determined beneficial effects such as: cytotoxic, antioxidant, neuroprotective, hepatoprotective, increased physical strength, stress-protective, anti-inflammatory [12,88,104].”

    From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [104]

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Authors
Yang, B., Guo, J., Li, Z., Wang, C., Wang, Z., Wang, Q., & Kuang, H.
Affiliations
  • Heilongjiang University of Chinese Medicine (CN)
  • Key Laboratory of Chinese Materia Medica (Ministry of Education) Heilongjiang University of Chinese Medicine 24 HePing Road Harbin 150040 P. R. China
Venue
Chemistry & Biodiversity
Publisher
Wiley
Published
2016-09
Volume
13
Issue
9
Pages
1118-1125
ISSN
  • 1612-1872 (ISSN-L)
  • 1612-1880
OpenAlex
W2485139585
Cited by
20
References
25
Citations by year
2026: 1 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • Chemistry & Biodiversity (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81473325)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Rehabilitation › Magnolia and Illicium research
Keywords
Schisandra chinensis, lignans, amyloid-beta 42, neuroprotection, PC12 cells, neurotoxicity, structure elucidation, natural product isolation
MeSH terms
Animals, Cell Survival, Glycosides, Peptide Fragments, Molecular Structure, Benzoquinones, Amyloid beta-Peptides, PC12 Cells, Lignans, Plant Stems, Neuroprotective Agents, Schisandra, Cyclooctanes, Rats

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