The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antihyperglycemic Effect of Puerarin in Streptozotocin-Induced Diabetic Rats
Abstract
The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
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Kaufman, P. B., Duke, J. A., Brielmann, H., Boik, J., & Hoyt, J. E. (1997) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1997.3.7 · Cited by 298
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Metadata
- Authors
- Hsu, F.-L., Liu, I.-M., Kuo, D.-H., Chen, W.-C., Su, H.-C., & Cheng, J.-T.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-05-28
- Volume
- 66
- Issue
- 6
- Pages
- 788-792
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W1980494536
- Cited by
- 221
- References
- 1
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
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