The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation
Open accessAbstract
Natural products continue to provide a diverse and unique source of bioactive lead compounds for drug discovery, but maintaining their continued eminence as source compounds is challenging in the face of the changing face of the pharmaceutical industry and the changing nature of biodiversity prospecting brought about by the Convention on Biological Diversity. This review provides an overview of some of these challenges and suggests ways in which they can be addressed so that natural products research can remain a viable and productive route to drug discovery. Results from International Cooperative Biodiversity Groups (ICBGs) working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery.
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Cites
Biodiversity hotspots for conservation priorities
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Natural products as sources of new drugs over the last 25 years
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Halichondrins-antitumor polyether macrolides from a marine sponge
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Cited by
Current approaches and challenges for the metabolite profiling of complex natural extracts
Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635
The pharmaceutical industry and natural products: historical status and new trends
David, B., Wolfender, J.-L., & Dias, D. A. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-014-9367-z · Cited by 579
Nothias, L.-F., Nothias-Esposito, M., da Silva, R., Wang, M., Protsyuk, I., Zhang, Z., Sarvepalli, A., Leyssen, P., Touboul, D., Costa, J., et al. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00737 · Cited by 433
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Spradlin, J. N., Hu, X., Ward, C. C., Brittain, S. M., Jones, M. D., Ou, L., To, M., Proudfoot, A., Ornelas, E., Woldegiorgis, M., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0304-8 · Cited by 432
Natural product isolation – how to get from biological material to pure compounds
Bucar, F., Wube, A., & Schmid, M. (2013) · Natural Product Reports · doi:10.1039/c3np20106f · Cited by 373
Metadata
- Authors
- Kingston, D. G. I.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-07
- Volume
- 74
- Issue
- 3
- Pages
- 496-511
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2018976898
- Cited by
- 516
- References
- 5
- FWCI
- 24.74
- Type
- journal article
- Language
- en
- Open access
- green
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