The structure of ulithiacyclamide B. Antitumor evaluation of cyclic peptides and macrolides from Lissoclinum patella
Abstract
The major cytotoxic metabolites of Lissoclinum patella from Pohnpei have been isolated and identified. Most of the cytotoxicity is attributed to a new cyclic peptide, ulithiacyclamide B [4], which is closely related to ulithiacyclamide [1]. The proposed structure of 4 is based on spectroscopic analysis and chemical degradation. Compound 4 exhibits an IC50 of 17 ng/ml against the KB cell line but does not show selective cytotoxicity against solid tumor cells in the Corbett assay.
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
“and Lissoclinum patella [90–92], exhibited potent cytotoxic activity against a human nasopharyngeal carcinoma cell line at IC50 value of 17 and 3000 ng/mL, respectively [93].”
BackgroundCyanobactins—ribosomal cyclic peptides produced by cyanobacteria
Sivonen, K., Leikoski, N., Fewer, D. P., & Jokela, J. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2482-x · Cited by 275 · see citing works
- Authors
- Williams, D. E., Moore, R. E., & Paul, V. J.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1989-07
- Volume
- 52
- Issue
- 4
- Pages
- 732-739
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2013613554
- Cited by
- 49
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA12623)
- National Institute of General Medical Sciences (GM38624)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- Lissoclinum patella, cyclic peptides, macrolides, cytotoxic metabolites, anticancer activity, KB cells, structure elucidation, marine sponges, Pohnpei
- MeSH terms
- Amino Acids, Animals, Anti-Bacterial Agents, Antineoplastic Agents, Chemistry, Chemistry, Physical, Chromatography, High Pressure Liquid, Hydrolysis, Leukemia L1210, Magnetic Resonance Spectroscopy, Peptides, Cyclic, Triazoles, Tumor Cells, Cultured, Macrolides, Mice, Chemical Phenomena
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