Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria
Open accessAbstract
Cyanobactins are small cyclic peptides that are produced by a diverse selection of cyanobacteria living in symbioses as well as terrestrial, marine, or freshwater environments. They include compounds with antimalarial, antitumor, and multidrug reversing activities and potential as pharmaceutical leads. Cyanobactins are produced through the proteolytic cleavage and cyclization of precursor peptides coupled with further posttranslational modifications such as heterocyclization, oxidation, or prenylation of amino acids. Cyanobactin gene clusters encode two proteases which cleave and cyclisize the precursor peptide as well as proteins participating in posttranslational modifications. The bioinformatic mining of cyanobacterial genomes has led to the discovery of novel cyanobactins. Heterologous expression of these gene clusters provided insights into the role of the genes participating in the biosynthesis of cyanobactins and facilitated the rational design of novel peptides. Enzymes participating in the biosynthesis of cyanobactins may prove useful as catalysts for producing novel cyclic peptides in the future. The recent discovery of the cyanobactin biosynthetic pathway in cyanobacteria extends our knowledge of their potential as producers of interesting metabolites.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cyanobacteria produce various metabolites by the ribosomal or non-ribosomal pathway, most of which are peptides or alkaloids.
“Cyanobacteria produce various metabolites by the ribosomal or non-ribosomal pathway. Most of these compounds are either peptides or alkaloids [241].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [241]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bacteriocins of gram-positive bacteria
Jack, R. W., Tagg, J. R., & Ray, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.171-200.1995 · Cited by 2,711 · see citing works
Tillett, D., Dittmann, E., Erhard, M., von Döhren, H., Börner, T., & Neilan, B. A. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00021-1 · Cited by 996 · see citing works
Marine cyanobacteria—a prolific source of natural products
Burja, A. M., Banaigs, B., Abou-Mansour, E., Grant Burgess, J., & Wright, P. C. (2001) · Tetrahedron · doi:10.1016/s0040-4020(01)00931-0 · Cited by 841 · see citing works
Cyanobacterial peptides — Nature's own combinatorial biosynthesis
Welker, M., & von Döhren, H. (2006) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2006.00022.x · Cited by 780 · see citing works
Boyd, M. R., Gustafson, K. R., McMahon, J. B., Shoemaker, R. H., O’Keefe, B. R., Mori, T., Gulakowski, R. J., Wu, L., Rivera, M. I., Laurençot, C. M., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1521 · Cited by 606 · see citing works
Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567 · see citing works
Diversity of enterococcal bacteriocins and their grouping in a new classification scheme
Franz, C. M. A. P., van Belkum, M. J., Holzapfel, W. H., Abriouel, H., & Gálvez, A. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00064.x · Cited by 443 · see citing works
The Cyanobacteria: Molecular Biology, Genomics and Evolution
Los, D. A., Suzuki, I., Зинченко, В. В., & Murata, N. (2008) · Cited by 426 · see citing works
Follow the leader: the use of leader peptides to guide natural product biosynthesis
Oman, T. J., & van der Donk, W. A. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.286 · Cited by 405 · see citing works
High diversity of cultivable heterotrophic bacteria in association with cyanobacterial water blooms
Berg, K. A., Lyra, C., Sivonen, K., Paulin, L. G., Suomalainen, S., Tuomi, P. M., & Rapala, J. (2008) · The ISME Journal · doi:10.1038/ismej.2008.110 · Cited by 292 · see citing works
Self-citationA global assembly line for cyanobactins
Donia, M. S., Ravel, J., & Schmidt, E. W. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.84 · Cited by 279 · see citing works
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
Donia, M. S., Hathaway, B. J., Sudek, S., Haygood, M. G., Rosovitz, M. J., Ravel, J., & Schmidt, E. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio829 · Cited by 261 · see citing works
The cyanobacteria : molecular biology, genomics, and evolution
Herrero, A., & Flores, E. (2008) · Caister Academic Press eBooks · Cited by 252 · see citing works
Discovery of a widely distributed toxin biosynthetic gene cluster
Lee, S. W., Mitchell, D. A., Markley, A. L., Hensler, M. E., Gonzalez, D. J., Wohlrab, A. M., Dorrestein, P. C., Nizet, V., & Dixon, J. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801338105 · Cited by 206 · see citing works
A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium
Bokesch, H. R., O’Keefe, B. R., McKee, T. C., Pannell, L. K., Patterson, G. M. L., Gardella, R. S., Sowder, R. C., Turpin, J. A., Watson, K. M., Robert W. Buckheit, et al. (2003) · Biochemistry · doi:10.1021/bi0205698 · Cited by 205 · see citing works
Linington, R. G., González, J., Ureña, L.-D., Romero, L. I., Ortega‐Barría, E., & Gerwick, W. H. (2007) · Journal of Natural Products · doi:10.1021/np0605790 · Cited by 195 · see citing works
Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90
Rouhiainen, L., Paulin, L. G., Suomalainen, S., Hyytiäinen, H., Buikema, W. J., Haselkorn, R., & Sivonen, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01982.x · Cited by 177 · see citing works
Self-citationAntineoplastic cyclic peptides from the marine tunicate Lissoclinum patella
Ireland, C. M., Durso, A. R., Newman, R. A., & Hacker, M. P. (1982) · The Journal of Organic Chemistry · doi:10.1021/jo00349a002 · Cited by 177 · see citing works
Genetic features of circular bacteriocins produced by Gram-positive bacteria
Maqueda, M., Sánchez‐Hidalgo, M., Fernández, M., Montalbán‐López, M., Valdivia, E., & Martínez‐Bueno, M. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00087.x · Cited by 172 · see citing works
Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria
Ziemert, N., Ishida, K., Liaimer, A., Hertweck, C., & Dittmann, E. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802730 · Cited by 157 · see citing works
Novel cytotoxic compounds from the ascidian Lissoclinum bistratum
Degnan, B. M., Hawkins, C. J., Lavin, M. F., et al. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00126a035 · Cited by 156 · see citing works
Banker, R., & Carmeli, S. (1998) · Journal of Natural Products · doi:10.1021/np980138j · Cited by 152 · see citing works
New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella
Degnan, B. M., Hawkins, C. J., Lavin, M. F., McCaffrey, E. J., Parry, D. L., van den Brenk, A. L., & Watters, D. J. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00126a034 · Cited by 150 · see citing works
Todorova, A. K., Juettner, F., Linden, A., Pluess, T., & von Philipsborn, W. (1995) · The Journal of Organic Chemistry · doi:10.1021/jo00129a032 · Cited by 147 · see citing works
Ulicyclamide and ulithiacyclamide, two new small peptides from a marine tunicate
Ireland, C. M., & Scheuer, P. J. (1980) · Journal of the American Chemical Society · doi:10.1021/ja00537a053 · Cited by 146 · see citing works
Ogino, J., Moore, R. E., Patterson, G. M. L., & Smith, C. D. (1996) · Journal of Natural Products · doi:10.1021/np960178s · Cited by 140 · see citing works
Lee, J., McIntosh, J. A., Hathaway, B. J., & Schmidt, E. W. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8092168 · Cited by 140 · see citing works
Lantibiotics and microcins: polypeptides with unusual chemical diversity
Jack, R. W., & Jung, G. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00094-6 · Cited by 136 · see citing works
Portmann, C., Blom, J. F., Gademann, K., & Jüttner, F. (2008) · Journal of Natural Products · doi:10.1021/np800118g · Cited by 134 · see citing works
Portmann, C., Blom, J. F., Kaiser, M., Brun, R., Jüttner, F., & Gademann, K. (2008) · Journal of Natural Products · doi:10.1021/np800409z · Cited by 132 · see citing works
Schmitz, F. J., Ksebati, M. B., Chang, J. S., et al. (1989) · The Journal of Organic Chemistry · doi:10.1021/jo00275a036 · Cited by 129 · see citing works
Sudek, S., Haygood, M. G., Youssef, D. T. A., & Schmidt, E. W. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-06 · Cited by 128 · see citing works
Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria
Ziemert, N., Ishida, K., Liaimer, A., Hertweck, C., & Dittmann, E. (2008) · Angewandte Chemie · doi:10.1002/ange.200802730 · Cited by 125 · see citing works
Post‐translational Modification in Microviridin Biosynthesis
Philmus, B. J., Christiansen, G., Yoshida, W. Y., & Hemscheidt, T. K. (2008) · ChemBioChem · doi:10.1002/cbic.200800560 · Cited by 122 · see citing works
Prinsep, M. R., Moore, R. E., Levine, I. A., & Patterson, G. M. L. (1992) · Journal of Natural Products · doi:10.1021/np50079a022 · Cited by 121 · see citing works
Ziemert, N., Ishida, K., Quillardet, P., Bouchier, C., Hertweck, C., de Marsac, N. T., & Dittmann, E. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02392-07 · Cited by 121 · see citing works
Ishida, K., Matsuda, H., Murakami, M., et al. (1997) · Journal of Natural Products · doi:10.1021/np970146k · Cited by 116 · see citing works
Algicidal effect of the bacterium Alcaligenes denitrificans on Microcystis spp.
Manage, P. M., Kawabata, Z., & Nakano, S. (2000) · Aquatic Microbial Ecology · doi:10.3354/ame022111 · Cited by 113 · see citing works
Nostocyclamide M: a cyanobacterial cyclic peptide with allelopathic activity from Nostoc 31
Jüttner, F., Todorova, A. K., Walch, N., & von Philipsborn, W. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00470-2 · Cited by 112 · see citing works
How Nature Morphs Peptide Scaffolds into Antibiotics
Nolan, E. M., & Walsh, C. T. (2008) · ChemBioChem · doi:10.1002/cbic.200800438 · Cited by 106 · see citing works
Foster, M. P., Concepción, G. P., Caraan, G. B., & Ireland, C. M. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00050a063 · Cited by 102 · see citing works
Non-Toxic Peptides from Toxic Cyanobacteria, Oscillatoria agardhii
Fujii, K., Sivonen, K., Naganawa, E., & Harada, K. (2000) · Tetrahedron · doi:10.1016/s0040-4020(99)01017-0 · Cited by 100 · see citing works
Self-citationMartin‐Visscher, L. A., Gong, X., Duszyk, M., & Vederas, J. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036459 · Cited by 99 · see citing works
Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate Didemnum molle
Donia, M. S., Wang, B., Dunbar, D. C., Desai, P. V., Patny, A., Avery, M. A., & Hamann, M. T. (2008) · Journal of Natural Products · doi:10.1021/np700718p · Cited by 93 · see citing works
New Cyclic Peptides from the AscidianLissoclinumpatella
Fu, X., Do, T., Schmitz, F. J., Andrusevich, V. E., & Engel, M. H. (1998) · Journal of Natural Products · doi:10.1021/np9802872 · Cited by 89 · see citing works
Hawkins, C. J., Lavin, M. F., Marshall, K. A., et al. (1990) · Journal of Medicinal Chemistry · doi:10.1021/jm00168a016 · Cited by 89 · see citing works
Cyclic peptide structures from the tunicate Lissoclinum patella by FAB mass spectrometry
Wasylyk, J. M., BISKUPIAK, J. E., Costello, C. E., et al. (1983) · The Journal of Organic Chemistry · doi:10.1021/jo00172a001 · Cited by 88 · see citing works
Cycloxazoline: A cytotoxic cyclic hexapeptide from the ascidian lissoclinum bistratum.
Hambley, T. W., Hawkins, C. J., Lavin, M. F., van den Brenk, A. L., & Watters, D. J. (1992) · Tetrahedron · doi:10.1016/s0040-4020(01)88146-1 · Cited by 88 · see citing works
Highly Diverse Cyanobactins in Strains of the Genus Anabaena
Leikoski, N., Fewer, D. P., Jokela, J., Wahlsten, M., Rouhiainen, L., & Sivonen, K. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01061-09 · Cited by 86 · see citing works
Self-citationBioactive compounds produced by cyanobacteria
Sivonen, K., & Börner, T. (2008) · Cited by 86 · see citing works
Self-citationBistratamides E−J, Modified Cyclic Hexapeptides from the Philippines Ascidian Lissoclinum bistratum
Perez, L. J., & Faulkner, D. J. (2003) · Journal of Natural Products · doi:10.1021/np0204601 · Cited by 82 · see citing works
Solution and solid-state conformations of ascidiacyclamide, a cytotoxic cyclic peptide from ascidian
Ishida, T., Tanaka, M., Nabae, M., et al. (1988) · The Journal of Organic Chemistry · doi:10.1021/jo00236a022 · Cited by 81 · see citing works
Microcyclamide, a Cytotoxic Cyclic Hexapeptide from the Cyanobacterium Microcystis aeruginosa
Ishida, K., Nakagawa, H., & Murakami, M. (2000) · Journal of Natural Products · doi:10.1021/np000159p · Cited by 79 · see citing works
Isolation and Structure of the Marine Sponge Cell Growth Inhibitory Cyclic Peptide Phakellistatin 1
Pettit, G. R., Cichacz, Z. A., Barkoczy, J., et al. (1993) · Journal of Natural Products · doi:10.1021/np50092a011 · Cited by 78 · see citing works
Kobayashi, J., Tsuda, M., Nakamura, T., Mikami, Y., & Shigemori, H. (1993) · Tetrahedron · doi:10.1016/s0040-4020(01)86318-3 · Cited by 74 · see citing works
McDonald, L. A., Foster, M. P., Phillips, D. R., et al. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00043a017 · Cited by 72 · see citing works
Dolastatin 3 and Two Novel Cyclic Peptides from a Palauan Collection of Lyngbya majuscula
Mitchell, S. S., Faulkner, D. J., Rubins, K., & Bushman, F. D. (2000) · Journal of Natural Products · doi:10.1021/np990353f · Cited by 70 · see citing works
Patellamide E: a New Cyclic Peptide from the Ascidian Lissoclinum patella
McDonald, L. A., & Ireland, C. M. (1992) · Journal of Natural Products · doi:10.1021/np50081a016 · Cited by 70 · see citing works
Leikoski, N., Fewer, D. P., & Sivonen, K. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02134-08 · Cited by 67 · see citing works
Self-citationModified peptides from a water bloom of the cyanobacterium Nostoc sp.
Ploutno, A., & Carmeli, S. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)01326-1 · Cited by 67 · see citing works
Patellamide F, a New Cytotoxic Cyclic Peptide from the Colonial Ascidian Lissoclinum patella
Rashid, M. A., Gustafson, K. R., Cardellina, J. H., et al. (1995) · Journal of Natural Products · doi:10.1021/np50118a020 · Cited by 64 · see citing works
Cyclic Heptapeptides from the Jamaican Sponge Stylissa caribica
Mohammed, R. A., Peng, J., Kelly, M., et al. (2006) · Journal of Natural Products · doi:10.1021/np060006n · Cited by 62 · see citing works
Isolation and Structure of the Cytotoxic Cycloheptapeptide Phakellistatin 13
Li, W., Yi, Y., Wu, H., et al. (2002) · Journal of Natural Products · doi:10.1021/np020223y · Cited by 62 · see citing works
Compounds produced from potential tunicate-blue-green algal symbiosis: A review
Sings, H. L., & RINEHART, K. L. J. (1996) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01574769 · Cited by 61 · see citing works
Didmolamide A and B, Two New Cyclic Hexapeptides from the Marine Ascidian Didemnum molle
Rudi, A., Chill, L., Aknin, M., & Kashman, Y. (2003) · Journal of Natural Products · doi:10.1021/np020531w · Cited by 59 · see citing works
Pettit, G. R., Gao, F., Cerny, R. L., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00034a014 · Cited by 59 · see citing works
Raocyclamides A and B, Novel Cyclic Hexapeptides Isolated from the Cyanobacterium Oscillatoria raoi
Admi, V., Afek, U., & Carmeli, S. (1996) · Journal of Natural Products · doi:10.1021/np960115+ · Cited by 55 · see citing works
Cyclodidemnamide: A new cyclic heptapeptide from the marine ascidian Didemnum Molle
Toske, S. G., & Fenical, W. (1995) · Tetrahedron Letters · doi:10.1016/0040-4039(95)01806-s · Cited by 54 · see citing works
Studies on the solution- and solid-state structure of patellin 2
Zabriskie, T. M., Foster, M. P., Stout, T. J., et al. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00178a035 · Cited by 53 · see citing works
Wewakazole, a Novel Cyclic Dodecapeptide from a Papua New Guinea Lyngbya majuscula
Nogle, L. M., Márquez, B. L., & Gerwick, W. H. (2002) · Organic Letters · doi:10.1021/ol026811k · Cited by 53 · see citing works
Kawaguchipeptin A, a novel cyclic undecapeptide from cyanobacterium Microcystis aeruginosa (NIES-88)
Ishida, K., Matsuda, H., Murakami, M., et al. (1996) · Tetrahedron · doi:10.1016/0040-4020(96)00452-8 · Cited by 51 · see citing works
Chapter 23 Cyanobactin Ribosomally Synthesized Peptides—A Case of Deep Metagenome Mining
Schmidt, E. W., & Donia, M. S. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(09)04823-x · Cited by 50 · see citing works
Four new cytotoxic cyclic hexa- and heptapeptides from the marine ascidian Didemnum molle
Rudi, A., Aknin, M., Gaydou, E. M., et al. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00801-1 · Cited by 50 · see citing works
Williams, D. E., Moore, R. E., & Paul, V. J. (1989) · Journal of Natural Products · doi:10.1021/np50064a011 · Cited by 49 · see citing works
Sone, H., Kigoshi, H., & Yamada, K. (1997) · Tetrahedron · doi:10.1016/s0040-4020(97)00504-8 · Cited by 47 · see citing works
Solid-Phase Total Synthesis of Trunkamide A1
Caba, J. M., Rodriguez, I. M., Manzanares, I., Giralt, E., & Alberício, F. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo015703t · Cited by 46 · see citing works
Pettit, G. R., Tan, R., Williams, M. D., et al. (1993) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)80781-2 · Cited by 46 · see citing works
A New Antifouling Hexapeptide from a Palauan Sponge, Haliclona sp.
Sera, Y., Adachi, K., Fujii, K., et al. (2003) · Journal of Natural Products · doi:10.1021/np020271i · Cited by 45 · see citing works
Three novel metabolites from a bloom of the cyanobacterium Microcystis sp.
Gesner-Apter, S., & Carmeli, S. (2008) · Tetrahedron · doi:10.1016/j.tet.2008.05.031 · Cited by 45 · see citing works
Tabudravu, J. N., Morris, L. A., den Bosch, J. J. K.-V., & Jaspars, M. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)01993-1 · Cited by 45 · see citing works
Ireland, C. M., & Scheuer, P. J. (1980) · ChemInform · doi:10.1002/chin.198046329 · Cited by 44 · see citing works
Total synthesis of the cytotoxic cyclopeptide mollamide, isolated from the sea squirt Didemnum molle
McKeever, B., & Pattenden, G. (2003) · Tetrahedron · doi:10.1016/s0040-4020(03)00293-x · Cited by 43 · see citing works
Morris, L. A., van den Bosch, J. J. K., Versluis, K., et al. (2000) · Tetrahedron · doi:10.1016/s0040-4020(00)00746-8 · Cited by 43 · see citing works
Tabudravu, J. N., Morris, L. A., den Bosch, J. J. K.-V., & Jaspars, M. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00898-0 · Cited by 42 · see citing works
Baumann, H. I., Keller, S., Wolter, F. E., NICHOLSON, G. J., Jung, G., Süßmuth, R. D., & Jüttner, F. (2007) · Journal of Natural Products · doi:10.1021/np0700873 · Cited by 40 · see citing works
Dolastatin E, a new cyclic hexapeptide isolated from the sea hare Dolabella auricularia
Ojika, M., Nemoto, T., NAKAMURA, M., et al. (1995) · Tetrahedron Letters · doi:10.1016/0040-4039(95)00922-y · Cited by 40 · see citing works
Salvatella, X., Caba, J. M., Alberício, F., & Giralt, E. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo026464s · Cited by 40 · see citing works
Pettit, G. R., Xu, J., Cichacz, Z. A., Williams, M. D., Chapuis, J., & Cerny, R. L. (1994) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)80695-8 · Cited by 40 · see citing works
Schmidt, G., Grube, A., & Köck, M. (2007) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200700013 · Cited by 38 · see citing works
Tabudravu, J. N., Jaspars, M., Morris, L. A., den Bosch, J. J. K.-V., & Smith, N. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo020482s · Cited by 36 · see citing works
Shin, H. J., Matsuda, H., Murakami, M., & Yamaguchi, K. (1996) · Tetrahedron · doi:10.1016/0040-4020(96)00775-2 · Cited by 35 · see citing works
Tsuda, M., Sasaki, T., & Kobayashi, J. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)85006-7 · Cited by 34 · see citing works
Pettit, G. R., Xu, J.-P., Dorsaz, A.-C., et al. (1995) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/0960-894x(95)00219-j · Cited by 32 · see citing works
Prenylagaramides A and B, New Cyclic Peptides from Two Strains of Oscillatoria agardhii
Murakami, M., Itou, Y., Ishida, K., & Shin, H. J. (1999) · Journal of Natural Products · doi:10.1021/np980396g · Cited by 32 · see citing works
Synthesis, structural aspects and bioactivity of the marine cyclopeptide hymenamide C
Napolitano, A., Bruno, I., Rovero, P., Lucas-Domínguez, R., Peris, M. P., Gomez‐Paloma, L., & Riccio, R. (2001) · Tetrahedron · doi:10.1016/s0040-4020(01)00579-8 · Cited by 31 · see citing works
Pettit, G. R., & Tan, R. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)01054-5 · Cited by 31 · see citing works
Isolation and Evaluation of Nonsiderophore Cyclic Peptides from Marine Sponges
Guan, L. L., Sera, Y., Adachi, K., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4890 · Cited by 29 · see citing works
Cyclonellin, a New Cyclic Octapeptide from the Marine Sponge Axinella carteri
Milanowski, D. J., Rashid, M. A., Gustafson, K. R., et al. (2004) · Journal of Natural Products · doi:10.1021/np030336x · Cited by 26 · see citing works
Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle
Teruya, T., Sasaki, H., & Suenaga, K. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.06.086 · Cited by 26 · see citing works
Arrault, A., Witczak, A., Gonzalez, P., Tapissier‐Bontemps, N., & Banaigs, B. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)00693-7 · Cited by 23 · see citing works
Foster, M. P., & Ireland, C. M. (1993) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)60468-9 · Cited by 17 · see citing works
Pettit, G. R., & Tan, R. (2003) · ChemInform · doi:10.1002/chin.200324172 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
Bacteriocins—A viable alternative to antibiotics?
Cotter, P. D., Ross, R. P., & Hill, C. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2937 · Cited by 1,793 · see citing works
Improving the coverage of the cyanobacterial phylum using diversity driven genome sequencing
Shih, P. M., Wu, D., Latifi, A., Axen, S. D., Fewer, D. P., Talla, E., Calteau, A., Cai, F., Tandeau de Marsac, N., Rippka, R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217107110 · Cited by 800 · see citing works
Self-citationEcology of Cyanobacteria II: Their Diversity in Space and Time
(2012) · doi:10.1007/978-94-007-3855-3 · Cited by 1,078 · see citing works
Immense essence of excellence: Marine microbial bioactive compounds
Bhatnagar, I., & Kim, S.-K. (2010) · Marine Drugs · doi:10.3390/md8102673 · Cited by 384 · see citing works
- Authors
- Sivonen, K., Leikoski, N., Fewer, D. P., & Jokela, J.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Sivonen, Kaarina
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2010-02-27
- Volume
- 86
- Issue
- 5
- Pages
- 1213-1225
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- PMC
- PMC2854353
- OpenAlex
- W2085960153
- Cited by
- 275
- References
- 102
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 20 · 2023: 20 · 2022: 18 · 2021: 11 · 2020: 13 · 2019: 25 · 2018: 20 · 2017: 13 · 2016: 16 · 2015: 20 · 2014: 21 · 2013: 17 · 2012: 22
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Applied Microbiology and Biotechnology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Academy of Finland (118637)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- cyanobactins, cyanobacteria, cyclic peptides, gene clusters, proteolytic cleavage, cyclization, post-translational modification, heterocyclization, prenylation, heterologous expression, antimalarial compounds, anticancer agents, natural product discovery, biosynthetic enzymes
- MeSH terms
- Cyanobacteria, Amino Acid Sequence, Bacterial Proteins, Biotechnology, Molecular Sequence Data, Peptides, Peptides, Cyclic, Ribosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
