The DOI matches its Crossref record.
Characterization of Spiroiminodihydantoin as a Product of One-Electron Oxidation of 8-Oxo-7,8-dihydroguanosine
Abstract
[reaction: see text] Further oxidation of the common DNA lesion 8-oxo-7,8-dihydroguanosine by one-electron oxidants such as IrCl6(2-), Fe(CN)6(3-), or SO4-* leads to two major products, depending upon reaction conditions. In nucleosides at pH 7, 22 degrees C, the principal product is shown herein to be a spiroiminodihydantoin nucleoside, as a diastereomeric mixture, that can be characterized by NMR, ESI-MS/MS, and independent synthesis.
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Citations
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Metadata
- Authors
- Luo, W., Muller, J. G., Rachlin, E. M., & Burrows, C. J.
- Venue
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-02-09
- Volume
- 2
- Issue
- 5
- Pages
- 613-616
- ISSN
- 1523-7052 (ISSN-L)
- 1523-7060
- OpenAlex
- W2058044047
- Cited by
- 242
- References
- 0
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
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