Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome
Abstract
The Ts65Dn mouse model of Down syndrome (DS) is trisomic for orthologs of 88 of 161 classical protein coding genes present on human chromosome 21 (HSA21). Ts65Dn mice display learning and memory impairments and neuroanatomical, electrophysiological, and cellular abnormalities that are relevant to phenotypic features seen in DS; however, little is known about the molecular perturbations underlying the abnormalities. Here we have used reverse phase protein arrays to profile 64 proteins in the cortex, hippocampus, and cerebellum of Ts65Dn mice and littermate controls. Proteins were chosen to sample a variety of pathways and processes and include orthologs of HSA21 proteins and phosphorylation-dependent and -independent forms of non-HSA21 proteins. Protein profiles overall show remarkable stability to the effects of trisomy, with fewer than 30% of proteins altered in any brain region. However, phospho-proteins are less resistant to trisomy than their phospho-independent forms, and Ts65Dn display abnormalities in some key proteins. Importantly, we demonstrate that Ts65Dn mice have lost correlations seen in control mice among levels of functionally related proteins, including components of the MAP kinase pathway and subunits of the NMDA receptor. Loss of normal patterns of correlations may compromise molecular responses to stimulation and underlie deficits in learning and memory.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In 4 to 8-month-old Ts65Dn mice, DYRK1A was upregulated in the cortex, cerebellum, and hippocampus.
“In 4 to 8-month-old Ts65Dn mice, DYRK1A was upregulated in the cortex, cerebellum, and hippocampus (Ahmed et al., 2012).”
From Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model (2024) · cites this paper as Ahmed et al., 2012
Discordant outcomes between Dyrk1a RNA and protein expression in brain have been reported in older male Ts65Dn mice, although these comparisons came from different experiments.
“Discordant outcomes between Dyrk1a RNA and protein expression in brain have been reported in older male Ts65Dn mice, although these comparisons came from different experiments (Ahmed et al., 2012; Choi et al., 2009; Sultan et al., 2007).”
From Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model (2024) · cites this paper as Ahmed et al., 2012
Cites
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · see citing works
Correlation of mRNA and protein in complex biological samples
Maier, T., Güell, M., & Serrano, L. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.036 · Cited by 1,802 · see citing works
Nishizuka, S., Charboneau, L., Young, L., Major, S. M., Reinhold, W. C., Waltham, M. C., Kouros‐Mehr, H., Bussey, K. J., Lee, J. K., Espina, V. A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331323100 · Cited by 474 · see citing works
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
Nixon, R. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.018 · Cited by 371 · see citing works
Tolias, K. F., Bikoff, J. B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R. J., & Greenberg, M. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.024 · Cited by 365 · see citing works
Down syndrome: Cognitive phenotype
Silverman, W. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20156 · Cited by 324 · see citing works
Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity
Yang, S.-H., Jaffray, E., Hay, R. T., & Sharrocks, A. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00265-x · Cited by 253 · see citing works
Protein microarrays: Molecular profiling technologies for clinical specimens
Espina, V. A., Mehta, A. I., Winters, M. E., Calvert, V. S., Wulfkuhle, J. D., Petricoin, E. F., & Liotta, L. A. (2003) · PROTEOMICS · doi:10.1002/pmic.200300592 · Cited by 235 · see citing works
MNB/DYRK1A as a multiple regulator of neuronal development
Tejedor, F. J., & Hämmerle, B. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07954.x · Cited by 214 · see citing works
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis
Zhang, H., & Macara, I. G. (2006) · Nature Cell Biology · doi:10.1038/ncb1368 · Cited by 213 · see citing works
Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L. S., & Greenberg, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702044104 · Cited by 201 · see citing works
Roncarati, R., Šestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P., Meucci, O., McGlade, J. C., RAKIC, P. T., & D'adamio, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102192599 · Cited by 193 · see citing works
Costa, A. C. S., Scott-McKean, J. J., & Stasko, M. R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301535 · Cited by 163 · see citing works
Braudeau, J., Delatour, B., Duchon, A., Pereira, P. L., Dauphinot, L., de Chaumont, F., Olivo‐Marín, J., Dodd, R. H., Hérault, Y., & Potier, M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111405366 · Cited by 163 · see citing works
Yabut, O., Domogauer, J., & D’Arcangelo, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4711-09.2010 · Cited by 154 · see citing works
Heat Stabilization of the Tissue Proteome: A New Technology for Improved Proteomics
Svensson, M., Borén, M., Sköld, K., Fälth, M., Sjögren, B., Andersson, M., Svenningsson, P., & Andrén, P. E. (2009) · Journal of Proteome Research · doi:10.1021/pr8006446 · Cited by 149 · see citing works
Faizi, M., Bader, P. L., Tun, C., Encarnacion, A., Kleschevnikov, A. M., Belichenko, P. V., Saw, N. L., Priestley, M., Tsien, R. W., Mobley, W. C., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.011 · Cited by 134 · see citing works
Vilardell, M., Rasche, A., Thormann, A., Maschke-Dutz, E., Jurado, L. A. P., Lehrach, H., & Herwig, R. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-229 · Cited by 126 · see citing works
Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
Sturgeon, X., & Gardiner, K. J. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9321-y · Cited by 117 · see citing works
Self-citationWulfkuhle, J. D., Edmiston, K. H., Liotta, L. A., & Petricoin, E. F. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0485 · Cited by 116 · see citing works
The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity
Hoe, H., Fu, Z., Makarova, A., Lee, J.-Y., Lu, C., Feng, L., Pajoohesh‐Ganji, A., Matsuoka, Y., Hyman, B. T., Ehlers, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900141200 · Cited by 114 · see citing works
Molecular basis of pharmacotherapies for cognition in Down syndrome
Gardiner, K. (2009) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.010 · Cited by 113 · see citing works
Self-citationTrazzi, S., Mitrugno, V. M., Valli, E., Fuchs, C., Rizzi, S., Guidi, S., Perini, G., Bartesaghi, R., & Ciani, E. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr033 · Cited by 112 · see citing works
Sananbenesi, F. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1188 · Cited by 110 · see citing works
Beta-Amyloid, Oxidative Stress and Down Syndrome
Lott, I. T., Head, E., Doran, E. W., & Busciglio, J. A. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025305 · Cited by 110 · see citing works
Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2
Nishimura, T., Yamaguchi, T., Tokunaga, A., Hara, A., Hamaguchi, T., Kato, K., Iwamatsu, A., Okano, H., & Kaibuchi, K. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0700 · Cited by 109 · see citing works
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1
Salinas, S., Briançon‐Marjollet, A., Bossis, G., Lopez, M.-A., Piechaczyk, M., Jariel‐Encontre, I., Debant, A., & Hipskind, R. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310136 · Cited by 96 · see citing works
Espina, V. A., Mueller, C., Edmiston, K. H., Sciro, M., Petricoin, E. F., & Liotta, L. A. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800001 · Cited by 95 · see citing works
Siarey, R. J., Kline‐Burgess, A., Cho, M., Balbo, A., Best, T. K., Harashima, C., Klann, E., & Galdzicki, Z. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03971.x · Cited by 86 · see citing works
Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome
Liu, D. P., Schmidt, C., Billings, T., & Davisson, M. T. (2003) · BioTechniques · doi:10.2144/03356st02 · Cited by 84 · see citing works
Self-citationChoi, J. H. K., Berger, J. D., Mazzella, M. J., Morales‐Corraliza, J., Cataldo, A. M., Nixon, R. A., Ginsberg, S. D., Levy, E., & Mathews, P. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06277.x · Cited by 83 · see citing works
Kyriazis, G. A., Wei, Z., Vandermey, M., Jo, D., Ouyang, X., Mattson, M. P., & Chan, S. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802072200 · Cited by 78 · see citing works
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes
Sultan, M., Piccini, I., Balzereit, D., Herwig, R., Saran, N. G., Lehrach, H., Reeves, R. H., & Yaspo, M.-L. (2007) · Genome Biology · doi:10.1186/gb-2007-8-5-r91 · Cited by 78 · see citing works
The proteins of human chromosome 21
Gardiner, K., & Costa, A. C. S. (2006) · American Journal of Medical Genetics. Part C, Seminars in Medical Genetics · doi:10.1002/ajmg.c.30098 · Cited by 74 · see citing works
Self-citationKeating, D. J., Chen, C., & Pritchard, M. A. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2005.11.001 · Cited by 71 · see citing works
Britschgi, M., Rufibach, K., Huang, S. L. B., Clark, C. M., Kaye, J. A., Li, G., Peskind, E. R., Quinn, J. F., Galasko, D. R., & Wyss‐Coray, T. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008862 · Cited by 71 · see citing works
Cousins, S. L., Hoey, S. E., Stephenson, F. A., & Perkinton, M. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06424.x · Cited by 68 · see citing works
Wang, X., Nadarajah, B., Robinson, A., McColl, B. W., Jin, J., Dajas‐Bailador, F., Boot-Handford, R., & Tournier, C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00226-07 · Cited by 66 · see citing works
Gioeli, D. G., Wunderlich, W., Sebolt, J. S., Bekiranov, S., Wulfkuhle, J. D., Petricoin, E. F., Conaway, M. C., & Weber, M. J. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-1033 · Cited by 66 · see citing works
Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801
Siddiqui, A. H., Lacroix, T., Stasko, M. R., Scott-McKean, J. J., Costa, A. C. S., & Gardiner, K. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00428.x · Cited by 64 · see citing works
Self-citationOverexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
Wolvetang, E. J., Bradfield, O., Hatzistavrou, T., Crack, P. J., Busciglio, J. A., Kola, I., & Hertzog, P. J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00107-4 · Cited by 56 · see citing works
Voshol, H., Ehrat, M., Traenkle, J., Bertrand, E., & van Oostrum, J. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07395.x · Cited by 56 · see citing works
Pathways to cognitive deficits in Down syndrome
Sturgeon, X., Le, T., Ahmed, M. M., & Gardiner, K. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00005-4 · Cited by 51 · see citing works
Self-citationHarris‐Cerruti, C., Kamsler, A., Kaplan, B., Lamb, B. T., Segal, M., & Groner, Y. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03188.x · Cited by 47 · see citing works
Sanij, E., Hatzistavrou, T., Hertzog, P. J., Kola, I., & Wolvetang, E. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5680 · Cited by 44 · see citing works
Numb and Numblike control cell number during vertebrate neurogenesis
Johnson, J. E. B. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00166-8 · Cited by 39 · see citing works
Ahmed, M. M., & Gardiner, K. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.01.004 · Cited by 37 · see citing works
Self-citationTiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
Fard, S. S., Kele, J., Vilar, M., Paratcha, G., & Ledda, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009647 · Cited by 33 · see citing works
Sun, Y., Dierssen, M., Torán, N., Pollak, D. D., Chen, W., & Lübec, G. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.01.009 · Cited by 27 · see citing works
Reverse Phase Protein Microarrays for Theranostics and Patient-Tailored Therapy
Espina, V. A., Wulfkuhle, J. D., Calvert, V. S., Liotta, L. A., & Petricoin, E. F. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-047-2_8 · Cited by 27 · see citing works
Building protein interaction maps for Down's syndrome
Gardiner, K. (2004) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/3.2.142 · Cited by 25 · see citing works
Self-citationCaspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis.
Qi, H., Juo, P., Robens, J., Caloca, M. J., Zhou, H., Stone, N. L., Kazanietz, M. G., & Chou, M. M. (2001) · PubMed · Cited by 25 · see citing works
Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome
Fernandez, F., Trinidad, J. C., Blank, M., Feng, D., Burlingame, A. L., & Garner, C. C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06110.x · Cited by 22 · see citing works
Quantitative Proteomics Characterization of a Mouse Embryonic Stem Cell Model of Down Syndrome
Wang, Y., Mulligan, C., Denyer, G. S., Delom, F., Dagna‐Bricarelli, F., Tybulewicz, V. L. J., Fisher, E., Griffiths, W. J., Nižetić, D., & Groet, J. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800256-mcp200 · Cited by 19 · see citing works
Machine Learning Methods Predict Locomotor Response to MK-801 in Mouse Models of Down Syndrome
Nguyen, C., Costa, A. C. S., Cios, K. J., & Gardiner, K. (2011) · Journal of Neurogenetics · doi:10.3109/01677063.2011.558606 · Cited by 13 · see citing works
Self-citationRueda, N., Flórez, J., & Martínez‐Cué, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.06.001 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Phenotypic impact of genomic structural variation: insights from and for human disease
Weischenfeldt, J., Symmons, O., Spitz, F., & Korbel, J. O. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3373 · Cited by 648 · see citing works
Higuera, C., Gardiner, K., & Cios, K. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129126 · Cited by 151 · see citing works
Self-citationGardiner, K. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s51476 · Cited by 114 · see citing works
Self-citationGnRH replacement rescues cognition in Down syndrome
Manfredi-Lozano, M., Leysen, V., Adamo, M., Paiva, I., Rovera, R., Pignat, J., Timzoura, F. E., Candlish, M., Eddarkaoui, S., Malone, S. A., et al. (2022) · Science · doi:10.1126/science.abq4515 · Cited by 98 · see citing works
DYRK1A Protein, A Promising Therapeutic Target to Improve Cognitive Deficits in Down Syndrome
Féki, A., & Hibaoui, Y. (2018) · Brain Sciences · doi:10.3390/brainsci8100187 · Cited by 71 · see citing works
Stringer, M., Abeysekera, I., Thomas, J. R., LaCombe, J., Stancombe, K., Stewart, R. B., Dria, K. J., Wallace, J. M., Goodlett, C. R., & Roper, R. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.05.003 · Cited by 59 · see citing works
Lanzillotta, C., Tramutola, A., Di Giacomo, G., Marini, F., Butterfield, D. A., Di Domenico, F., Perluigi, M., & Barone, E. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.042 · Cited by 47 · see citing works
Ahmed, M. M., Dhanasekaran, A. R., Block, A., Tong, S., Costa, A. C. S., Stasko, M. R., & Gardiner, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119491 · Cited by 45 · see citing works
Self-citationTargeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
Stringer, M., Goodlett, C. R., & Roper, R. J. (2017) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.334 · Cited by 44 · see citing works
Block, A., Ahmed, M. M., Dhanasekaran, A. R., Tong, S., & Gardiner, K. J. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0043-9 · Cited by 43 · see citing works
Self-citationProtein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain
Ahmed, M. M., Dhanasekaran, A. R., Tong, S., Wiseman, F. K., Fisher, E., Tybulewicz, V. L. J., & Gardiner, K. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt017 · Cited by 42 · see citing works
Self-citationAhmed, M. M., Johnson, N. R., Boyd, T. D., Coughlan, C. M., Chial, H. J., & Potter, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.718426 · Cited by 41 · see citing works
Self-citationTramutola, A., Lanzillotta, C., Arena, A., Barone, E., Marzia Perluigi, A., & Domenico, F. D. (2015) · Neurodegenerative Diseases · doi:10.1159/000441419 · Cited by 39 · see citing works
Toma, I. D., Ortega, M., Aloy, P., Sabidó, E., & Dierssen, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00272 · Cited by 30 · see citing works
Ahmed, M. M., Wang, A. C., Elos, M. T., Chial, H. J., Sillau, S., Solano, D. A., Coughlan, C. M., Aghili, L., Anton, P. E., Markham, N. E., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105694 · Cited by 30 · see citing works
Self-citationCognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome
Ruparelia, A., Pearn, M. L., & Mobley, W. C. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.05.002 · Cited by 26 · see citing works
Lanzillotta, C., Tramutola, A., Meier, S. E., Schmitt, F. A., Barone, E., Marzia Perluigi, A., Domenico, F. D., & Abisambra, J. F. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170617 · Cited by 25 · see citing works
Expression of trisomic proteins in Down syndrome model systems
Spellman, C., Ahmed, M. M., Dubach, D., & Gardiner, K. (2012) · Gene · doi:10.1016/j.gene.2012.10.051 · Cited by 24 · see citing works
Self-citationProtein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine
Ahmed, M. M., Dhanasekaran, A. R., Block, A., Tong, S., Costa, A. C. S., & Gardiner, K. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.035568 · Cited by 23 · see citing works
Self-citationTlili, A., Hoischen, A., Ripoll, C., Benabou, E., Badel, A., Ronan, A., Touraine, R. L., Grattau, Y., Stora, S., van Bon, B. W. M., et al. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8284-7 · Cited by 22 · see citing works
Mouton‐Liger, F., Sahún, I., Collin, T., Pereira, P. L., Masini, D., Thomas, S., Paly, E., Luilier, S., Même, S., Jouhault, Q., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.016 · Cited by 19 · see citing works
Ahmed, M. M., Carrel, A. J., Angel, Y. C. D., Carlsen, J., Thomas, A. X., González, M. I., Gardiner, K., & Brooks‐Kayal, A. R. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.654606 · Cited by 19 · see citing works
Self-citationNosheny, R. L., Belichenko, P. V., Busse, B. L., Weissmiller, A. M., Dang, V., Das, D., Fahimi, A., Salehi, A., Smith, S. J., & Mobley, W. C. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.022 · Cited by 17 · see citing works
Tallino, S., Winslow, W., Bartholomew, S. K., & Velázquez, R. (2022) · Aging Cell · doi:10.1111/acel.13590 · Cited by 15 · see citing works
Age exacerbates abnormal protein expression in a mouse model of Down syndrome
Ahmed, M. M., Block, A., Tong, S., Davisson, M. T., & Gardiner, K. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.002 · Cited by 16 · see citing works
Self-citationIshihara, K., & Akiba, S. (2017) · Brain Sciences · doi:10.3390/brainsci7040044 · Cited by 14 · see citing works
Block, A., Ahmed, M. M., Rueda, N., Hernandez, M., Martínez‐Cué, C., & Gardiner, K. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.038 · Cited by 11 · see citing works
Self-citationHawley, L. E., Stringer, M., Deal, A. J., Folz, A., Goodlett, C. R., & Roper, R. J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106359 · Cited by 10 · see citing works
“In 4 to 8-month-old Ts65Dn mice, DYRK1A was upregulated in the cortex, cerebellum, and hippocampus (Ahmed et al., 2012).”
Azimzadeh, M., Cheah, P.-S., & Ling, K. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150713 · Cited by 9 · see citing works
Franco, N. D., Drutel, G., Roullot, V., Julio‐Kalajzić, F., Lalanne, V., Grel, A., Lesté-Lasserre, T., Matias, I., Cannich, A., Gonzales, D., et al. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103705 · Cited by 7 · see citing works
Alldred, M. J., Ibrahim, K. W., Pidikiti, H., Lee, S. H., Heguy, A., Chiosis, G., Mufson, E. J., Stutzmann, G. E., & Ginsberg, S. D. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1546375 · Cited by 4 · see citing works
Tallino, S., Etebari, R., McDonough, I., Leon, H., Sepulveda, I., Winslow, W., Bartholomew, S. K., Perez, S. E., Mufson, E. J., & Velazquez, R. (2024) · Nutrients · doi:10.3390/nu16234167 · Cited by 3 · see citing works
Barros‐Santos, B., Campos‐Marques, C., Salvador, A. F., & Silva, J. M. (2025) · Brain Organoid and Systems Neuroscience Journal · doi:10.1016/j.bosn.2025.04.006 · Cited by 2 · see citing works
Ishihara, K. (2013) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.13-00167 · Cited by 1 · see citing works
RPPAware: A software suite to preprocess, analyze and visualize reverse phase protein array data
Dhanasekaran, A. R., & Gardiner, K. (2018) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720018500014 · Cited by 1 · see citing works
Self-citationBartholomew, S. K., Turk, J., Winslow, W., Foley, C., Shaw, A. Y., Rokey, S., Tallino, S., Judd, J. M., Beach, T. G., Serrano, G. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700091 · Cited by 1 · see citing works
Brain metabolic and behavioral alterations in a Down syndrome model
de Souza, L. E., Righini, C. M., Mantovani, D. B. D. A., Silva, M. P., Lazzarotto, G., Limberger, C., Buchpiguel, C. A., Zimmer, E. R., Real, C. C., Spelta, L. E. W., et al. (2025) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2025.109052
- Authors
- Ahmed, M. M., Sturgeon, X., Ellison, M., Davisson, M. T., & Gardiner, K. J.
- Affiliations
- University of Colorado Denver (US)
- Colorado School of Public Health (US)
- Jackson Laboratory (US)
- Corresponding author
- Gardiner, Katheleen J.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-25
- Volume
- 11
- Issue
- 2
- Pages
- 1251-1263
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W1990879185
- Cited by
- 39
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 1 · 2018: 3 · 2017: 5 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Proteome Research (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (n01hd073265-003, 5r01hd056235-05)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD73265, R01-HD056235, HD065235)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Ts65Dn mouse model, Down syndrome, trisomy, phosphoproteomics, MAPK signaling, NMDA receptor, learning and memory impairment, brain proteome, hippocampus, cortex, cerebellum
- MeSH terms
- Animals, Brain, Brain Chemistry, Disease Models, Animal, Down Syndrome, Female, Male, Mice, Transgenic, Nerve Tissue Proteins, Blotting, Western, Reproducibility of Results, Receptors, N-Methyl-D-Aspartate, Proteome, Protein Array Analysis, Extracellular Signal-Regulated MAP Kinases, Mice, Protein Interaction Maps
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
