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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

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Defects in Embryonic Neurogenesis and Initial Synapse Formation in the Forebrain of the Ts65Dn Mouse Model of Down Syndrome

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Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with down syndrome

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Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1

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Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

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Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells

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Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly

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Identification of Septins in Neurofibrillary Tangles in Alzheimer's Disease

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DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

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Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

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DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

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Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

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DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

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Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

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DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

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The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

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Dyrk1A Phosphorylates α-Synuclein and Enhances Intracellular Inclusion Formation

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Dyrk1A‐mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

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Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein Kinases

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Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

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Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation

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Coupling Cell Cycle Exit, Neuronal Differentiation and Migration in Cortical Neurogenesis

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Transgenic Mouse In Vivo Library of Human Down Syndrome Critical Region 1

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Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse

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Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division

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DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.

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High-Level Expression of the Mnb/Dyrk1A Gene in Brain and Heart during Rat Early Development

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DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1

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The spatio‐temporal and subcellular expression of the candidate Down syndrome gene <i>Mnb/Dyrk1A</i> in the developing mouse brain suggests distinct sequential roles in neuronal development

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Evidence of Arrest of Neurogenesis and Synaptogenesis in Brains of Patients with Down's Syndrome

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The MNB/DYRK1A protein kinase: Neurobiological functions and Down syndrome implications

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Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A

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The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

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Regulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling

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Sprouty2-Mediated Inhibition of Fibroblast Growth Factor Signaling Is Modulated by the Protein Kinase DYRK1A

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A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody

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Phosphorylation of Amphiphysin I by Minibrain Kinase/Dual-specificity Tyrosine Phosphorylation-regulated Kinase, a Kinase Implicated in Down Syndrome

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Dyrk1A Potentiates Steroid Hormone-Induced Transcription via the Chromatin Remodeling Factor Arip4

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Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology

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Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of down syndrome

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Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1A

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Mnb/Dyrk1A Phosphorylation Regulates the Interaction of Dynamin 1 with SH3 Domain-Containing Proteins

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p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

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Dyrk1A Binds to Multiple Endocytic Proteins Required for Formation of Clathrin-Coated Vesicles

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Unusual function of the activation loop in the protein kinase DYRK1A

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Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells

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Regulation of Dyrk1A kinase activity by 14-3-3

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Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

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Rapid turnover of cell‐cycle regulators found in Mirk/dyrk1B transfectants

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HAN11 binds mDia1 and controls GLI1 transcriptional activity

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Increased expression of Dyrk1a in HPV16 immortalized Keratinocytes enable evasion of apoptosis

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dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX

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Dopaminergic deficiency in mice with reduced levels of the dual‐specificity tyrosine‐phosphorylated and regulated kinase 1A, Dyrk1A+/−

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SNR1 (INI1/SNF5) Mediates Important Cell Growth Functions of the Drosophila Brahma (SWI/SNF) Chromatin Remodeling Complex

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Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA α-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein

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Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

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Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.

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Neurological phenotypes for Down syndrome across the life span

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Protective effects and mechanisms of sirtuins in the nervous system

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DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome

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The Down syndrome-related protein kinase DYRK1A phosphorylates p27^Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

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Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

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DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies

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The <i>DYRK1A</i> gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy

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Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A

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Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and Neuromorphological alterations found in a mouse model of down syndrome

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DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in down syndrome

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Dyrk1a from gene function in development and physiology to dosage correction across life span in down syndrome

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The Omnipresence of DYRK1A in Human Diseases

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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

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Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome

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Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders

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Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule

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Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

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Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome

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β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

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General Concepts of Neurodegeneration as Specificity of Mitochondrial Pathobiology of Neurons

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Mnb/Dyrk1A Phosphorylation Regulates the Interaction of Dynamin 1 with SH3 Domain-Containing Proteins

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Epigenetics of the Synapse in Neurodegeneration

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How neuroinflammation contributes to neurodegeneration

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