The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Association between Galactosylation of Immunoglobulin G and Improvement of Rheumatoid Arthritis during Pregnancy Is Independent of Sialylation
Open accessAbstract
Rheumatoid arthritis (RA) is known to improve during pregnancy and to flare after delivery. Changes in the glycosylation of immunoglobulin G (IgG)'s fragment crystallizable (Fc) have been suggested to play a role herein. Recent animal studies indicate that not galactosylation but mainly sialylation is important in this respect. We aim to find new associations between IgG-Fc N-glycosylation and improvement of RA during pregnancy and the flare after delivery. Sera of RA patients (n = 251 pregnancies) and healthy controls (n = 32), all participating in a prospective cohort study on RA and pregnancy (PARA study), were collected before conception, during pregnancy, and after delivery. Using a recently developed fast and robust nanoRP-HPLC-sheath-flow-ESI-MS method the glycosylation of IgG Fc-glycopeptides was measured in a subclass specific manner, with relative standard deviations of <4% for the 8 most abundant IgG Fc glycopeptides during the entire measurement period of over 3 weeks. In patients and controls, several glycosylation changes were observed during pregnancy. In depth analysis of the association of these glycosylation changes with disease activity revealed that galactosylation, independent of sialylation, is associated with improvement of RA during pregnancy. Functional studies in human cell systems should be performed to obtain more insight into this matter.
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Shields, R. L., Lai, J., Keck, R., O'Connell, L. Y., Hong, K., Meng, Y. G., Weikert, S. H. A., & Presta, L. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202069200 · Cited by 1,835
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754
Agalactosyl glycoforms of IgG autoantibodies are pathogenic
Rademacher, T. W., Williams, P., & Dwek, R. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6123 · Cited by 253
Cited by
IgG Subclasses and Allotypes: From Structure to Effector Functions
Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
Bondt, A., Rombouts, Y., Selman, M. H. J., Hensbergen, P. J., Reiding, K. R., Hazes, J. M. W., Dolhain, R. J. E. M., & Wuhrer, M. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.039537 · Cited by 264
Self-citationSubedi, G. P., Hanson, Q. M., & Barb, A. W. (2014) · Structure · doi:10.1016/j.str.2014.08.002 · Cited by 81
Metadata
- Authors
- Bondt, A., Selman, M. H. J., Deelder, A. M., Hazes, J. M. W., Willemsen, S. P., Wuhrer, M., & Dolhain, R. J. E. M.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-09-24
- Volume
- 12
- Issue
- 10
- Pages
- 4522-4531
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2040900310
- Cited by
- 168
- References
- 3
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Bondt, A., Selman, M. H. J., Deelder, A. M., Hazes, J. M. W., Willemsen, S. P., Wuhrer, M., & Dolhain, R. J. E. M. (2013). Association between Galactosylation of Immunoglobulin G and Improvement of Rheumatoid Arthritis during Pregnancy Is Independent of Sialylation. Journal of Proteome Research. https://doi.org/10.1021/pr400589m
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