The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals
Open accessAbstract
Analyzing the literature resources used in our previous reports, we calculated the fractions of the oxidoreductase enzymes FMO (microsomal flavin-containing monooxygenase), AKR (aldo-keto reductase), MAO (monoamine oxidase), and cytochrome P450 participating in metabolic reactions. The calculations show that the fractions of P450s involved in the metabolism of all chemicals (general chemicals, natural, and physiological compounds, and drugs) are rather consistent in the findings that >90% of enzymatic reactions are catalyzed by P450s. Regarding drug metabolism, three-fourths of the human P450 reactions can be accounted for by a set of five P450s: 1A2, 2C9, 2C19, 2D6, and 3A4, and the largest fraction of the P450 reactions is catalyzed by P450 3A enzymes. P450 3A4 participation in metabolic reactions of drugs varied from 13% for general chemicals to 27% for drugs.
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Cites
Rendic, S., & Carlo, F. J. D. (1997) · Drug Metabolism Reviews · doi:10.3109/03602539709037591 · Cited by 949
Self-citationWilliams, J. A., Hyland, R., Jones, B. C., Smith, D. A., Hurst, S., Goosen, T. C., Peterkin, V., Koup, J. R., & Ball, S. E. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000794 · Cited by 928
Predicting in vivo drug interactions from in vitro drug discovery data
Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 904
Summary of information on human CYP enzymes: human P450 metabolism data
Rendic, S. (2002) · Drug Metabolism Reviews · doi:10.1081/dmr-120001392 · Cited by 820
Self-citationContributions of Human Enzymes in Carcinogen Metabolism
Rendic, S., & Guengerich, F. P. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300132k · Cited by 279
Self-citationMast, N., Norcross, R., Andersson, U., Shou, M., Nakayama, K., Björkhem, I., & Pikuleva, I. A. (2003) · Biochemistry · doi:10.1021/bi035512f · Cited by 132
Guengerich, F. P., & Cheng, Q. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003525 · Cited by 103
Self-citationPharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice
Mast, N., Li, Y., Linger, M., Clark, M., Wiseman, J. S., & Pikuleva, I. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.532846 · Cited by 90
Shafaati, M., Mast, N., Beck, O., Nayef, R., Heo, G. Y., Björkhem‐Bergman, L., Lütjohann, D., Björkhem, I., & Pikuleva, I. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900174-jlr200 · Cited by 59
Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1
Mast, N., Zheng, W., Stout, C. D., & Pikuleva, I. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438754 · Cited by 45
Zhang, D., Flint, O. P., Wang, L., Gupta, A. K., Westhouse, R. A., Zhao, W., Raghavan, N., Caceres‐Cortes, J., Marathe, P., Shen, G., et al. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200524d · Cited by 27
Cited by
Cytochrome P450 Enzymes and Drug Metabolism in Humans
Zhao, M., Ma, J., Li, M., Zhang, Y., Jiang, B., Zhao, X., Huai, C., Shen, L., Zhang, N., He, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312808 · Cited by 1,070
Metadata
- Authors
- Rendic, S., & Guengerich, F. P.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-12-19
- Volume
- 28
- Issue
- 1
- Pages
- 38-42
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2322012164
- Cited by
- 477
- References
- 11
- FWCI
- 19.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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