The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Structural Defects Play a Major Role in the Acute Lung Toxicity of Multiwall Carbon Nanotubes: Physicochemical Aspects
Abstract
Carbon nanotubes (CNT) have been reported to elicit toxic responses in vitro and in vivo, ascribed so far to metal contamination, CNT length, degree of oxidation, or extent of hydrophilicity. To examine how structural properties may modulate the toxicity of CNT, one preparation of multiwall CNT has been modified (i) by grinding (introducing structural defects) and subsequently heating either in a vacuum at 600 degrees C (causing reduction of oxygenated carbon functionalities and reduction of metallic oxides) or in an inert atmosphere at 2400 degrees C (causing elimination of metals and annealing of defects) and (ii) by heating at 2400 degrees C in an inert atmosphere and subsequently grinding the thermally treated CNT (introducing defects in a metal-deprived carbon framework). The presence of framework and surface defects, metals, and oxygenated functionalities was monitored by means of a set of techniques, including micro-Raman spectroscopy, adsorption calorimetry, X-ray photoelectron spectroscopy, inductively coupled plasma mass spectrometry, and atomic emission spectroscopy. Contrary to traditional toxicants, such as asbestos, CNT may quench rather than generate oxygenated free radicals. The potential of the modified CNT to scavenge hydroxyl radicals was thus evaluated by means of electron spin resonance spectroscopy (spin trapping). The original ground material exhibited a scavenging activity toward hydroxyl radicals, which was eliminated by heating at 2400 degrees C but restored upon grinding. This scavenging activity, related to the presence of defects, appears to go paired with the genotoxic and inflammatory potential of CNT reported in the companion paper. Thus, defects may be one of the major factors governing the toxic potential of CNT.
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Oops they did it again! Carbon nanotubes hoax scientists in viability assays
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Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells
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Self-citationMuller, J., Huaux, F., Fonseca, A., Nagy, J. B., Moreau, N., Delos, M., Raymundo-Piñero, E., Béguin, F., Kirsch-Volders, M., Fenoglio, I., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800101p · Cited by 261
Self-citationChemical aspects of the toxicity of inhaled mineral dusts
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Self-citationBioavailability of Nickel in Single‐Wall Carbon Nanotubes
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Cited by
Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yamashita, Y., Akatsuka, S., Ishihara, T., Yamashita, K., Yoshikawa, Y., Yasui, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110013108 · Cited by 535
Physico-chemical features of engineered nanoparticles relevant to their toxicity
Fubini, B., Ghiazza, M., & Fenoglio, I. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.509519 · Cited by 297
Self-citationMuller, J., Huaux, F., Fonseca, A., Nagy, J. B., Moreau, N., Delos, M., Raymundo-Piñero, E., Béguin, F., Kirsch-Volders, M., Fenoglio, I., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800101p · Cited by 261
Self-citationBoyles, M. S. P., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., Smail, F., Smith, P. J. W., Proudfoot, L., Windle, A. H., et al. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.06.012 · Cited by 182
Multiple aspects of the interaction of biomacromolecules with inorganic surfaces
Fenoglio, I., Fubini, B., Ghibaudi, E. M., & Turci, F. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.08.001 · Cited by 176
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Metadata
- Authors
- Fenoglio, I., Greco, G., Tomatis, M., Muller, J., Raymundo-Piñero, E., Béguin, F., Fonseca, A., Nagy, J. B., Lison, D., & Fubini, B.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-18
- Volume
- 21
- Issue
- 9
- Pages
- 1690-1697
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2086822315
- Cited by
- 302
- References
- 10
- FWCI
- 19.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fenoglio, I., Greco, G., Tomatis, M., Muller, J., Raymundo-Piñero, E., Béguin, F., Fonseca, A., Nagy, J. B., Lison, D., & Fubini, B. (2008). Structural Defects Play a Major Role in the Acute Lung Toxicity of Multiwall Carbon Nanotubes: Physicochemical Aspects. Chemical Research in Toxicology. https://doi.org/10.1021/tx800100s
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