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Cited by 53Bone health and osteoporosis researchLiver Disease and TransplantationBone Metabolism and Diseases

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Early Increase of Bone Resorption in Patients with Liver Cirrhosis Secondary to Viral Hepatitis

Corazza, Gino Roberto, Trevisani, Franco, Di Stefano, Michele, De Notariis, Stefania, Veneto, Graziamaria, Cecchetti, Loredana, Minguzzi, Licia, Gasbarrini, Giovanni, Bernardi, Mauro·2000·Digestive Diseases and Sciences
DOI 10.1023/a:1005568406664
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Abstract

Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone mineral density measurement at lumbar and femoral levels and the evaluation of bone and mineral metabolism and gonadal function were performed in 31 patients with liver cirrhosis and 37 healthy volunteers. Lumbar and femoral bone mineral density values were significantly lower in patients than in healthy volunteers. Prevalence and severity of bone loss increased according to the severity of liver disease. All serum indices of bone and mineral metabolism and of gonadal function showed a similar behavior, but a significant increase of bone resorption was present in all Child-Pugh classes. In particular, class A patients showed normal mean bone mineral density values but increased serum levels of the telopeptide of type I collagen. Liver cirrhosis predisposes to bone loss regardless of the presence of cholestasis. The severity of metabolic osteopathy worsens as liver function does. The underlying mechanism is represented by an increased bone resorption.

Overview

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Registry

Crossref · 10.1023/a:1005568406664

Cites

49 of 49 references verified0 citation errors · 0 not checkable

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  • Viral hepatitis is associated with an activated immune response and the release of mostly resorption-activating cytokines.

    “viral hepatitis is associated with an activated immune response and the release of mostly resorption-activating cytokines (Table 2) [4,5,6,7,8,45,54,55,56].”

    From Bone diseases in patients with chronic liver disease (2019) · cites this paper as [55]

Citations

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Research works printed but not linked: 1

  1. Hussaini SH, Roman F, Oldroyd B, Stewart SP, Bramley P, Simpson M, Smith MA, Losowsky MS: Does bone mineral density change after orthotopic liver transplantation? Gastroenterology 108:A1088, 1995

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Metadata

Authors
Corazza, G. R., Trevisani, F., Di Stefano, M., De Notariis, S., Veneto, G., Cecchetti, L., Minguzzi, L., Gasbarrini, G., & Bernardi, M.
Affiliations
University of Pavia (IT)
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2000-07
Volume
45
Issue
7
Pages
1392-1399
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/a:1005568406664
OpenAlex
W18136986
Cited by
53
References
49
Citations by year
2025: 3 · 2023: 3 · 2021: 1 · 2020: 5 · 2019: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
liver cirrhosis, viral hepatitis, bone resorption, bone loss, bone mineral density, metabolic bone disease, mineral metabolism, gonadal function, Child-Pugh score
MeSH terms
Adult, Aged, Bone Resorption, Collagen, Female, Femur, Hepatitis, Viral, Human, Humans, Liver Cirrhosis, Lumbosacral Region, Male, Middle Aged, Peptides, Reference Values, Spine, Bone Density, Collagen Type I

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