A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies

Jia, Shu-Fang; Worth, Laura L.; Kleinerman, Eugenie S.

doi:10.1023/a:1006623001465

Cited by 148Sarcoma Diagnosis and TreatmentCancer Cells and MetastasisBone health and treatments

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A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies

Jia, Shu-Fang, Worth, Laura L., Kleinerman, Eugenie S.·1999·Clinical & Experimental Metastasis

DOI 10.1023/a:1006623001465

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Abstract

The purpose of these studies was to develop a metastatic osteosarcoma nude mouse model to evaluate the in vivo efficacy of new therapeutic compounds. Human SAOS-2 osteosarcoma cells (10(6) cells) were injected i.v. into nude mice. Cells isolated from a rare pulmonary metastases 6 months later were established (SAOS-LM1) in culture and re-injected. This procedure was repeated 5 additional times to produce the SAOS-LM6 cell line. Visible pulmonary nodules were present 8 weeks following i.v. injection of 10(6) SAOS-LM6 cells as compared to 17 weeks using SAOS-LM2 cells. Microscopic SAOS-LM6 pulmonary metastases were demonstrated at 6 weeks. Administration of adriamycin on week 9 resulted in regression of macroscopic SAOS-LM6 lung tumors. The ability of the model to be used to evaluate the effectiveness of a biologic agent against microscopic disease was also verified. It was concluded that this model can assess therapeutic efficacy and therefore, may have a role in investigating the potential of novel approaches aimed at eliminating pulmonary metastatic osteosarcoma.

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Companion cell lines with enhanced lung colonization capacity have enabled study of metastasis-driving mechanisms.
“Companion cell lines with enhanced lung colonization capacity, such as SaOS2-LM7, MG63.3 and 143B 209,210,211 , have enabled the study of metastasis-driving mechanisms 50,212 .”
From Osteosarcoma (2022) · cites this paper as [209]

Selection of Successive Tumour Lines for Metastasis
Fidler, I. J. (1973) · Nature New Biology · doi:10.1038/newbio242148a0 · Cited by 1,365
The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity
Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A., Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142502 · Cited by 1,203
Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial.
Eilber, F. R., Giuliano, A. E., Eckardt, J. J., Patterson, K., Moseley, S. H., & Goodnight, J. E. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.1.21 · Cited by 524
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
Morikawa, K., Walker, S. M., Nakajima, M., Pathak, S., Jessup, J. M., & Fidler, I. J. (1988) · PubMed · Cited by 474
Metastatic behavior of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude mice.
Giavazzi, R., Campbell, D., Jessup, J. M., Cleary, K. R., & Fidler, I. J. (1986) · PubMed · Cited by 239
Survival Following Aggressive Resection of Pulmonary Metastases from Osteogenic Sarcoma: Analysis of Prognostic Factors
Putnam, J. B., Roth, J. A., Wesley, M. N., Johnston, M. R., & Rosenberg, S. A. (1983) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)60679-0 · Cited by 179
Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice.
Berlin, Ö., Samid, D., Donthineni-Rao, R., Akeson, W. H., Amiel, D., & Woods, V. L. (1993) · PubMed · Cited by 150
Changing pattern of pulmonary metastases with adjuvant chemotherapy in patients with osteosarcoma: results from the multiinstitutional osteosarcoma study.
Goorin, A. M., Shuster, J. J., Baker, A., Horowitz, M. E., Meyer, W. H., & Link, M. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.4.600 · Cited by 134
Efficacy of Liposomal Muramyl Tripeptide (CGP 19835A) in the Treatment of Relapsed Osteosarcoma
Kleinerman, E. S., Gano, J. B., Johnston, D. A., Benjamin, R. S., & Jaffe, N. (1995) · American Journal of Clinical Oncology · doi:10.1097/00000421-199504000-00001 · Cited by 116
Self-citation
Retroviral Vector-Mediated Transfer of an Antisense Cyclin G1 Construct Inhibits Osteosarcoma Tumor Growth in Nude Mice
Chen, D. S., Zhu, N., Hung, G., Skotzko, M. J., Hinton, D. R., Tolo, V. T., Hall, F. L., Anderson, W. F., & Gordon, E. M. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.14-1667 · Cited by 50
Timing of chemotherapy and surgery in a murine osteosarcoma model.
Bell, R. S., Roth, Y. F., Gebhardt, M. C., Bell, D. F., Rosenberg, A. E., Mankin, H. J., & Suit, H. D. (1988) · PubMed · Cited by 44
Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
Cobb, L. (1970) · British Journal of Cancer · doi:10.1038/bjc.1970.34 · Cited by 36
Development and characterization of pediatric osteosarcoma xenografts.
Meyer, W. H., Houghton, J. A., Houghton, P. J., Webber, B. L., Douglass, E. C., & Look, A. T. (1990) · PubMed · Cited by 29
In vitro and in vivo effect of adriamycin therapy on monocyte activation by liposome-encapsulated immunomodulators.
Hudson, M. M., Snyder, J. S., Jaffe, N., & Kleinerman, E. S. (1988) · PubMed · Cited by 28
Self-citation
Virus-induced animal model of osteosarcoma in the rat: Morphologic and biochemical studies.
Olson, H. M., & Capen, C. C. (1977) · PubMed Central · Cited by 20
Sequential therapy with chemotherapeutic drugs and liposome-encapsulated muramyl tripeptide: determination of potential interactions between these agents.
Killion, J. J., Kleinerman, E. S., Wilson, M. R., Tanaka, M., & Fidler, I. J. (1992) · PubMed · Cited by 19
Self-citation
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Jia, S.-F., An, T., Worth, L. L., & Kleinerman, E. S. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313758 · Cited by 14
Self-citation
Bone tumours induced in rats with radioactive cerium
Delbrück, H., Allouche, M., Jasmin, C., Morin, M., Deml, F., Anghileri, L. J., Masse, R. S., & Lafuma, J. (1980) · British Journal of Cancer · doi:10.1038/bjc.1980.145 · Cited by 12
The biology, pathology and immunology of a virus induced rat osteosarcoma
Czitrom, A. A., Langer, F., Gross, A. E., UROVITZ, E. P. M., & Pritzker, K. P. H. (1980) · International Orthopaedics · doi:10.1007/bf00268152 · Cited by 3
An experimental osteosarcoma of the athymic nude rat.
WITZEL, J. G., & Prescher, A. (1991) · PubMed · Cited by 3

Flagged first, then by citations

Research works printed but not linked: 5

Jaffe N. Chemotherapy in osteosarcoma: Experimental and clinical progress in cancer chemotherapy. In Muggia FM(ed): Advances and Controversies. Boston: Martinus Nijhoff Publishers 1986; 223–33.
Jia SF, Zwelling LA, McWatters A, ANT, Kleinerman ES. Interleukin-1? increase the cytotoxicity activity of etoposide against human osteosarcoma cells. J Exp Therap & Oncol (in press).
Jia SF, Fan D, Kleinerman ES. Synergestic enhancement of adriamycin cytotoxicity against human osteosarcoma cells by TNFα. Pro Am Assoc Cancer Res 1992; 33: 3301.
Samid D, Mandler R. Human osteosarcoma cells transformed by ras oncogenes: a new model for in vivo studies of pulmonary metastasis. Clinic Biotechnol 1989; 1: 21–6.
Olson HM, Capen CC. Virus-induced animal model of osteosarcoma in the rat. Am J Pathol 1977; 86: 437–52.

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Thompson, L., Wang, S., Tawfik, O. W., Templeton, K. J., Tancabelic, J., Pinson, D. M., Anderson, H. C., Keighley, J. D., & Garimella, R. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21585 · Cited by 42
Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing
Dass, C. R., Ek, E. T., & Choong, P. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0157-x · Cited by 42
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Lewis, V. O., Devarajan, E., Cardó‐Vila, M., Thomas, D. G., Kleinerman, E. S., Marchiò, S., Sidman, R. L., Pasqualini, R., & Arap, W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704173114 · Cited by 41
Self-citation
Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems
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Histone deacetylase inhibition prevents the growth of primary and metastatic osteosarcoma
McGuire, J., Nerlakanti, N., Lo, C. H., Tauro, M., Utset‐Ward, T. J., Reed, D. R., & Lynch, C. C. (2020) · International Journal of Cancer · doi:10.1002/ijc.33046 · Cited by 40
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Gordon, N. B., & Kleinerman, E. S. (2010) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2009.0812 · Cited by 40
Self-citation
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PosthumaDeBoer, J., van Egmond, P. W., Helder, M. N., de Menezes, R. X., Cleton-Jansen, A., Beliën, J. A. M., Verheul, H. M. W., van Royen, B. J., Kaspers, G. J. L., & van Beusechem, V. W. (2012) · Oncotarget · doi:10.18632/oncotarget.600 · Cited by 39
A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells
Talbot, L. J., Chabot, A., Funk, A., Nguyen, P., Wagner, J., Ross, A. B., Tillman, H. S., Davidoff, A. M., Gottschalk, S. M., & DeRenzo, C. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.691741 · Cited by 39
Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells
Nielsen‐Preiss, S. M., Silva, S. R., & Gillette, J. M. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10709 · Cited by 39
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Park, T. Y., Park, M. H., Shin, W. C., Rhee, M. H., Seo, D. W., Cho, J. Y., & Kim, H. M. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1802 · Cited by 37
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Loh, A. H. P., Stewart, E., Bradley, C. L., Chen, X., Daryani, V., Stewart, C. F., Calabrese, C., Funk, A., Miller, G., Karlstrom, A., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2018.10.033 · Cited by 36
p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma
Li, Y., Nakka, M., Kelly, A. J., Lau, C. C., Krailo, M., Barkauskas, D. A., Hicks, J. M., & Man, T. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3189 · Cited by 36
Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole
Liao, S., Ruiz, Y., Gulzar, H., Yelskaya, Z., Taouit, L. A., Houssou, M., Jaikaran, T., Schvarts, Y., Kozlitina, K., Basu-Roy, U., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171256 · Cited by 34
The Clinical Relevance of Molecular Genetics in Soft Tissue Sarcomas
Ordóñez, J. L., Osuna, D., García-Domínguez, D. J., Amaral, A. T., Otero-Motta, A. P., Mackintosh, C., Sevillano, V., Barbado, M. V., Hernández, T., & de Álava, E. (2010) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3181d98cbf · Cited by 34
Interleukin-12 Up-Regulates Fas Expression in Human Osteosarcoma and Ewing's Sarcoma Cells by Enhancing Its Promoter Activity
Zhou, Z., Lafleur, E. A., Koshkina, N. V., Worth, L. L., Lester, M. S., & Kleinerman, E. S. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0092 · Cited by 31
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Self-citation
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Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies
Schott, C. R., Shah, A. T., & Sweet-Cordero, A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43085-6_1 · Cited by 30
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Animal models of osteosarcoma
Fan, T. M. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.107 · Cited by 28
LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging
Zhang, J., Piao, C., Ding, J., & Li, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-69574-y · Cited by 27
MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts
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Self-citation
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Lisle, J. W., Choi, J. Y., Horton, J. A., Allen, M. J., & Damron, T. A. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0309-1 · Cited by 27
Polyethyleneimine-based gene therapy by inhalation
Densmore, C. L. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.7.1083 · Cited by 27
Retracted
Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases
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Kiany, S., Harrison, D., & Gordon, N. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43032-0_7 · Cited by 24
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness
Holme, H., Gulati, A., Brough, R., Fleuren, E. D. G., Bajrami, I., Campbell, J., Chong, I. Y.-S., Costa-Cabral, S., Elliott, R. J. R., Fenton, T. R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29043-z · Cited by 23
Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice
Raghubir, M., Rahman, C., Fang, J., Matsui, H., & Mahajan, S. S. (2019) · Oncology Reports · doi:10.3892/or.2019.7420 · Cited by 22
Engineering oncolytic vaccinia virus to redirect macrophages to tumor cells
Cao, F., Nguyen, P., Hong, B., DeRenzo, C. C., Rainusso, N. C., Rodríguez-Cruz, T., Wu, M., Liu, H., Song, X., Suzuki, M., et al. (2020) · Advances in Cell and Gene Therapy · doi:10.1002/acg2.99 · Cited by 21
The effect of bone morphogenetic protein-2 on osteosarcoma metastasis
Gill, J. B., Connolly, P. T., Roth, M. E., Chung, S. H., Zhang, W., Piperdi, S., Hoang, B. H., Yang, R. R., Guzik, H. M., Morris, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173322 · Cited by 21
A bioluminescent orthotopic mouse model of human osteosarcoma that allows sensitive and rapid evaluation of new therapeutic agents In vivo.
Comstock, K. E., Hall, C. L., Daignault, S. D., Mandlebaum, S., Yu, C., & Keller, E. T. (2009) · PubMed · Cited by 19
Aerosol Gene Therapy for Metastatic Lung Cancer Using PEI-p53 Complexes
Gautam, A. K., Waldrep, J. C., Xu, B., Fung, Y.-K. T., T'Ang, A., & Densmore, C. L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-324-0:607 · Cited by 19
Osteosarcoma progression is associated with increased nuclear levels and transcriptional activity of activated β-Catenin
Ali, N., Venkateswaran, G., Garcia, E. P., Landry, T., McColl, H., Sergi, C. M., Persad, A. R. L., Abuetabh, Y., Eisenstat, D. D., & Persad, S. (2019) · Genes & Cancer · doi:10.18632/genesandcancer.191 · Cited by 18
Non-invasive imaging correlates with histological and molecular characteristics of an osteosarcoma model: application for early detection and follow-up of MDR phenotype.
Dutour, A., Leclers, D., Monteil, J., Paraf, F., Charissoux, J.-L., Rousseau, R. F., & Rigaud, M. (2007) · PubMed · Cited by 17
Anti‐tumor efficacy of a transcriptional replication‐competent adenovirus, Ad‐OC‐E1a, for osteosarcoma pulmonary metastasis
Li, X., Jung, C., Liu, Y., Bae, K.-H., Zhang, Y.-P., Zhang, H., VanderPutten, D., Jeng, M., Gardner, T. A., & Kao, C. H. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.904 · Cited by 16
Invasive growth and topoisomerase-switch induced by tumorous extracellular matrix in osteosarcoma cell culture
Harisi, R., Dudás, J., Timár, F., Pogány, G., Tı́már, J., Kovalszky, I., Szendröi, M., & Jéney, A. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.08.010 · Cited by 16
Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features
Gutiérrez, L. M., Alvarez, M., Yang, Y., Spinelli, F. M., Cantero, M. J., Alaniz, L. D., García, M. G., Kleinerman, E. S., Correa, A., & Bolontrade, M. F. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01677-x · Cited by 15
Self-citation
ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper
Mandell, J. B., Douglas, N., Ukani, V., Beumer, J. H., Guo, J., Payne, J., Newman, R., Mancinelli, L., Intini, G., Anderson, C. J., et al. (2022) · Sarcoma · doi:10.1155/2022/7157507 · Cited by 15
Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase
Raghubir, M., Azeem, S. M., Hasnat, R., Rahman, C. N., Wong, L., Yan, S., Huang, Y. Q., Zhagui, R., Blyufer, A., Tariq, I., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00439-8 · Cited by 14

Establishment of nude mice model of human osteosarcoma cell MG63 with different potential of metastasis
Zhu, W., Guo, F., Xu, T., & Chen, A. (2007) · The Chinese-German Journal of Clinical Oncology · doi:10.1007/s10330-007-0068-6 · Cited by 2
An orthotopic model of human osteosarcoma using two isogenic cell lines differing in their ability to form spontaneous pulmonary metastasis
Comstock, K. E., Hall, C. L., Baker, L., & Keller, E. T. (2007) · Cancer Research
A bioluminescent orthotopic mouse model of human osteosarcoma that allows sensitive and rapid evaluation of new therapeutic agents In vivo.
Comstock, K. E., Hall, C. L., Daignault, S. D., Mandlebaum, S., Yu, C., & Keller, E. T. (2009) · PubMed · Cited by 19
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma
Kimura, K., 中野, 哲., Park, Y.-B., Tani, M., Tsuda, H., Beppu, Y., Moriya, H., & Yokota, J. (2002) · Clinical & Experimental Metastasis · doi:10.1023/a:1020395816633 · Cited by 29
Screening of human osteosarcoma cell line with spontaneous highly pulmonary metastasis in nude mice by orthotopic transplantation and studies on its biological characteristics
Zhang, D. (2000)

Authors: Jia, S.-F., Worth, L. L., & Kleinerman, E. S.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
ORCID: Kleinerman, Eugenie S.
Venue: Clinical & Experimental Metastasis
Publisher: Springer Science and Business Media LLC
Published: 1999-10
Volume: 17
Issue: 6
Pages: 501-506
ISSN: 0262-0898 (ISSN-L)
1573-7276
DOI: 10.1023/a:1006623001465
OpenAlex: W186831022
Cited by: 146
References: 20
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 8
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Clinical & Experimental Metastasis (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA-42992, CA-16672, R01CA042992, P30CA016672)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: osteosarcoma, lung metastasis, nude mouse model, Saos-2 cells, doxorubicin, treatment efficacy assessment, biologic agents
MeSH terms: Animals, Antineoplastic Agents, Disease Models, Animal, Doxorubicin, Drug Screening Assays, Antitumor, Etoposide, Humans, Lung Neoplasms, Mice, Nude, Neoplasm Transplantation, Osteosarcoma, Vinblastine, Cytokines, Mice

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A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies

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