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Decreased Susceptibility of Heart Mitochondria from Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium Phosphate
Open accessAbstract
Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death. The aim of this work was to compare the differences in susceptibility of induction of the MPT with calcium phosphate in GK and Wistar rats. Our results show that heart mitochondria from GK rats are less susceptible to the induction of MPT, and show a larger calcium accumulation before the overall loss of mitochondrial impermeability.
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In Goto-Kakizaki diabetic rat model with milder hyperglycemia, antiapoptotic proteins are upregulated.
“Conversely, milder hyperglycemia observed in the Goto-Kakizaki diabetic rat model was associated with upregulation of antiapoptotic proteins (116), a phenomenon that might represent an adaptive change to a milder condition.”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [116]
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Metadata
- Authors
- Oliveira, P. J., Rolo, A. P., Seiça, R., Palmeira, C. M., Santos, M. S., & Moreno, A. J. M.
- Affiliations
- University of Coimbra (PT)
- ORCID
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2001-02-01
- Volume
- 21
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W1541318946
- Cited by
- 32
- References
- 17
- Citations by year
- 2023: 1 · 2020: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Bioscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial permeability transition, type 2 diabetes, Goto-Kakizaki rats, heart mitochondria, calcium phosphate, mitochondrial calcium accumulation, mitochondrial dysfunction, mitochondrial permeability transition pore, Wistar rats
- MeSH terms
- Animals, Calcium, Calcium Phosphates, Cell Membrane Permeability, Diabetes Mellitus, Type 2, Enzyme Inhibitors, Fluorescent Dyes, Male, Mitochondria, Heart, Myocardium, Organic Chemicals, Rats, Mutant Strains, Subcellular Fractions, Cyclosporine, Rats, Wistar, Rats
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