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Effect of Coffee on Motor and Sensory Function of Proximal Stomach
Abstract
Some people attribute dyspeptic symptoms to drinking coffee, suggesting that coffee affects one or more functions of the proximal gastrointestinal tract. In a randomized controlled, cross-over, single-blinded study, the effects of coffee on gastric relaxation, gastric wall compliance and sensations, elicited by distension, were investigated in 10 healthy volunteers. Using the barostat technique, volume changes of an intragastric bag were recorded for 20 min after intragastric administration of 280 ml of coffee or water. Then, after deflation, the volume of the bag was increased stepwise every 3 min to assess gastric wall compliance and wall tension. At the end of every volume step, sensations (nausea, pain, and bloating) were scored. During the first 20 min after coffee administration, the volume change of the intragastric bag was larger than after water (P < 0.05). There were no differences in gastric wall compliance, wall tension, or symptom scores. In conclusions, coffee, in comparison with water, enhances the adaptive relaxation of the proximal stomach, but has no effect on its wall compliance, wall tension, or sensory function.
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Coffee does not modify gastric wall compliance, wall tension, or sensory function.
“Indeed, despite the relaxing effects of the proximal stomach, coffee did not modify gastric wall compliance, wall tension, or sensory function [139].”
From Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis (2020) · cites this paper as [139]
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Cited by
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Pathophysiology and treatment of functional dyspepsia
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“Rather, in healthy subjects, coffee was found to have no adverse effect on the motor and sensory function of the proximal stomach.(58) Likewise, doctors tend to discourage consumption of spicy food containing capsaicin.”
BackgroundEffects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis
Iriondo-DeHond, A., Uranga, J. A., del Castillo, M. D., & Abalo, R. (2020) · Nutrients · doi:10.3390/nu13010088 · Cited by 126
“Indeed, despite the relaxing effects of the proximal stomach, coffee did not modify gastric wall compliance, wall tension, or sensory function [139].”
BackgroundWang, N., Xiao, M., & Savin, I. V. (2020) · The Journal of Technology Transfer · doi:10.1007/s10961-020-09780-y · Cited by 83
A Comprehensive Overview of the Risks and Benefits of Coffee Consumption
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Jee, S. R., Jung, H., Min, B., Choi, K. D., Rhee, P., Kang, Y. W., Lee, S. I., & The Korean Society of Neurogastroenterology and Motility (2011) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2011.57.2.67 · Cited by 32
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Duangjai, A., Rawangkan, A., Yosboonruang, A., Ontawong, A., Saokaew, S., Goh, B. H., Suganuma, M., & Phisalprapa, P. (2024) · Foods · doi:10.3390/foods13152307 · Cited by 2
“…despite the observed relaxation effect on the proximal stomach, a randomized, controlled, crossover, single-blinded study using the barostat technique provided evidence that the study did not find any significant changes in gastric wall compliance or sensations following coffee consumption [24].”
ResultBeşen, M. A., Yılmaz, S. G., Durukan, H., & Aygün, E. S. A. (2026) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.70436 · Cited by 1
Metadata
- Authors
- Boekema, P. J., Samsom, M., Roelofs, J. M. M., & Smout, A. J. P. M.
- Affiliations
- University Medical Center Utrecht (NL)
- ORCID
- Smout, André J.P.M.
- Venue
- Digestive Diseases and Sciences
- Published
- 2001-05
- Volume
- 46
- Issue
- 5
- Pages
- 945-951
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W11283219
- Cited by
- 11
- References
- 48
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 2 · 2016: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- coffee, proximal stomach, gastric relaxation, gastric distension, dyspepsia, nausea, bloating
- MeSH terms
- Adult, Coffee, Compliance, Humans, Male, Middle Aged, Sensation, Stomach, Water, Cross-Over Studies
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