CoChat
Sign Up
Cited by 28Pharmacogenetics and Drug MetabolismPharmaceutical studies and practicesAnimal testing and alternatives

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and Rats

Chiou, Win L., Hsu, Fung-Hwa·1988·Pharmaceutical Research
DOI 10.1023/a:1015935206569
Open this paper in CoChat — free account

Abstract

Unbound plasma clearances (CLu) in humans and rats of 15 extensively metabolized drugs (phenytoin, hexobarbital, pentobarbital, phenylbutazone, warfarin, tolbutamide, valproate, phenobarbital, amobarbital, quinidine, chlorpromazine, propranolol, pentazocin, antipyrine, and diazepam), studied earlier by Sawada et al. (J. Pharmacokin, Biopharm. 13:477-491, 1985), were calculated. It was found that the ratio of CLu per square meter of body surface area between human and rat ranged from 0.38 for pentobarbital to 2.34 for tolbutamide, with a mean ratio of 1.07. When body weight (BW) was used for correlation, the mean CLu was proportional to BW 0.657 +/- 0.0935. A rationale for the above empirical findings is postulated. The present study seems to indicate the existence of a general similarity or predictability in the CLu of drugs between rats and humans. Low correlations were generally obtained when total (bound and unbound) plasma clearances were used for comparison.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1015935206569

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 35 references

Research works printed but not linked: 11

  1. H. Boxenbaum and R. Ronfeld. Am J. Physiol. 245:R768–R744 (1983).
  2. L. B. Mullett. Prog. Drug. Res. 13:136–169 (1969).
  3. E. J. Freireich, E. A. Gehan, D. P. Rall, L. H. Schmidt, and H. E. Skipper. Cancer Chemother. Rep. 50:219–244 (1966).
  4. F. H. Hsu. Absorption and Disposition of Chlorothiazide in Rats, Ph.D. thesis, University of Illinois at Chicago, 1987.
  5. R. L. Dedrick and K. B. Bischoff. Fed. Proc. 39:54–59 (1980).
  6. H. Bartels. Expl. Biol. Med. 7:1–11 (1982).
  7. F. H. Hsu, T. Prueksaritanont, M. G. Lee, and W. L. Chiou. Pharm. Res. 3:107S (1986).
  8. W. L. Chiou. Int. J. Clin. Pharmacol. Ther. Toxicol. 22:577–590 (1984).
  9. W. L. Chiou. J. Clin. Hosp. Pharm. 7:20–30 (1982).
  10. W. L. Chiou. Res. Commun. Chem. Pathol. Pharmacol. 56:121–124 (1987).
  11. H. J. Lee, Y. S. Choo, T. M. Chen, and W. L. Chiou. Pharm. Res. 3:152S (1986).

Cited by

Sorted by citations

See all 28

Related

See all

Metadata

Authors
Chiou, W. L., & Hsu, F.-H.
Affiliations
University of Illinois Chicago (US)
ORCID
Chiou, Win L.
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
1988-10
Volume
5
Issue
10
Pages
668-672
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/a:1015935206569
OpenAlex
W39205234
Cited by
28
References
35
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Keywords
human-rat comparison, body surface area, body weight, drug metabolism, phenytoin, barbiturates, antiepileptic drugs, antipsychotic drugs, antihypertensive drugs, antipyrine, diazepam, warfarin, quinidine, chlorpromazine, propranolol, tolbutamide, valproic acid
MeSH terms
Animals, Body Surface Area, Pharmaceutical Preparations, Humans, Liver, Male, Species Specificity, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and Rats. https://app.cochat.ai/papers/10.1023/a:1015935206569
The paper
Chiou, W. L., & Hsu, F.-H. (1988). Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and Rats. Pharmaceutical Research. https://doi.org/10.1023/a%3A1015935206569