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Cited by 70Analytical Methods in PharmaceuticalsPhysical Organic Chemistry and Reaction KineticsThermal and Kinetic Analysis

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Kinetics of Degradation of Levothyroxine in Aqueous Solution and in Solid State

Won, Chong Min·1992·Pharmaceutical Research
DOI 10.1023/a:1018952415732
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Abstract

The kinetics of the deiodination of levothyroxine in aqueous solution were studied over the pH range 1 to 12. Temperature dependence of the reaction was also studied. The log k - pH profile indicated that the kinetics of deiodination include proton attack on the anion and dianion in acidic solution and water attack on the anion and dianion in alkaline solution. A possible mechanism of the deiodination was discussed. The solid-state stability of levothyroxine sodium was studied at elevated temperatures; and the compound was found to undergo deamination on heating. The decomposition follows biphasic first-order kinetics, with the most rapid decomposition occurring at the beginning of heating.

Overview

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Registry

Crossref · 10.1023/a:1018952415732

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 1

  1. A. L. Reviczky and S. B. Nagy. Untersuchung der Thyroxindejodisation mit instrumenteller analytischer Methode. Endokrinologie 56:81–91 (1970).

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Metadata

Authors
Won, C. M.
Corresponding author
Won, Chong Min
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
1992-01
Volume
9
Issue
1
Pages
131-137
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/a:1018952415732
OpenAlex
W1600533342
Cited by
69
References
13
Citations by year
2025: 3 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 2
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
  • Physical Sciences › Chemistry › Organic Chemistry › Physical Organic Chemistry and Reaction Kinetics
  • Physical Sciences › Materials Science › Materials Chemistry › Thermal and Kinetic Analysis
Keywords
levothyroxine, deiodination, degradation kinetics, pH dependence, temperature dependence, water attack, reaction mechanism, levothyroxine sodium, solid-state stability, thermal decomposition, deamination, aqueous solutions
MeSH terms
Chromatography, High Pressure Liquid, Dosage Forms, Drug Stability, Hydrogen-Ion Concentration, Iodine, Solubility, Solutions, Thyroxine, Water, Molecular Structure

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