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Immune Abnormalities Induced by Human Endogenous Retroviral Peptides: With Reference to the Pathogenesis of Systemic Lupus Erythematosus
Abstract
P15E is a specific sequence among the envelope gene (env)-encoded transmembrane proteins of exogenous and endogenous retroviruses. A synthetic peptide (CKS- 17) that shows homology to this p15E region in several species of retrovirus is known to induce immune abnormalities. In this study, we examined the effect of a synthetic peptide derived from a region of human endogenous retrovirus (HERV) clone 4-1 (lambda4 - 1) similar to sequences of CKS-17 on the induction of systemic lupus erythematosus (SLE)-related immune abnormalities. Our results indicated that this peptide could induce T-cell activation and anergy in normal peripheral blood mononuclear cells, and the peptide could also promote the production of interleukins IL-6 and IL-16. These phenomena are representative immune abnormalities observed in SLE patients. Thus, our findings support the possibility that HERV acts as a pathogen in human SLE.
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Immunosuppressive potential has been demonstrated for the env of HERV-E, HERV-H, and syncytins.
“Indeed, immunosuppressive potential has been demonstrated for the env of HERV-E 52, HERV-H 53, as well as syncytins 54.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [52]
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Research works printed but not linked: 2
- Ogasawara H, Naito T, Kaneko H, Hishikawa T, Sekigawa I, Hashimoto H, Kaneko Y, Yamamoto N, Maruyama N, Yamamoto N: Quantitative analyses of messenger RNA of human endogenous retrovirus in SLE patients. J Rheumatol 28: 533–538, 2001
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Sorted by citations
Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity
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Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78
“Indeed, immunosuppressive potential has been demonstrated for the env of HERV-E [52], HERV-H [53], as well as syncytins [54].”
Background
Metadata
- Authors
- Naito, T., Ogasawara, H., Kaneko, H., Hishikawa, T., Sekigawa, I., Hashimoto, H., & Maruyama, N.
- Affiliations
- Juntendo University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Corresponding author
- Sekigawa, Iwao
- Venue
- Journal of Clinical Immunology
- Published
- 2003-09
- Volume
- 23
- Issue
- 5
- Pages
- 371-376
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W1480278634
- Cited by
- 28
- References
- 32
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 6 · 2013: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- systemic lupus erythematosus, human endogenous retroviruses, p15E, synthetic peptides, T cell activation, T cell anergy, interleukin-6, interleukin-16, autoimmunity, retroviral pathogenesis
- MeSH terms
- Cells, Cultured, HLA-DR Antigens, Humans, Interleukin-2, Lupus Erythematosus, Systemic, Peptides, Retroviridae Proteins, Interleukin-16
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