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Cited by 11Sperm and Testicular FunctionHormonal and reproductive studiesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Men with Acquired Hypogonadotropic Hypogonadism Treated with Testosterone may be Fertile

Drincic, Andjela, Arseven, Onur Karamanoglu, Sosa, Ernesto, Mercado, Moises, Kopp, Peter, Molitch, Mark E.·2003·Pituitary
DOI 10.1023/a:1026232124988
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Abstract

Men with acquired hypogonadotropic hypogonadism treated with testosterone are generally assumed to be infertile. The finding of two such patients with unexpected fertility and normal sperm counts prompted an evaluation of spermatogenesis in additional men with this condition. Case records were initially searched and one similar case with fertility was found. Subsequently, 12 consecutive men with acquired hypogonadotropic hypogonadism were evaluated for gonadal function and sperm production while receiving testosterone. In five of the cases with proven spermatogenesis, exon 10 of the FSH receptor was sequenced to look for activating mutations. The original three cases and four of the subsequent 12 men had sperm concentrations > or = 15 million/ml. Two additional men had concentrations of 1 million/ml and six were azoospermic. Residual LH and FSH levels were slightly higher in those with maintained spermatogenesis prior to testosterone replacement. No activating mutations were found in exon 10 of the FSH receptor in the five cases studied. We conclude that men with acquired hypogonadotropic hypogonadism being treated with testosterone should not be assumed to be sterile, as we have found that more than half have been shown to have persistent spermatogenesis with more than one-third having sperm concentrations > or = 15 million/ml. This may be related to fact that gonadotropin levels in such patients are present, albeit low. Semen analyses in such men should be routinely carried…

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Crossref · 10.1023/a:1026232124988

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40 of 40 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Winters SJ. Clinical disorders of the testis. In: DeGroot LJ, Jameson JL, eds., Endocrinology, 4th ed. Philadelphia: W. B. Saunders Co., 2001:2269–2290.

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Metadata

Authors
Drincic, A., Arseven, O. K., Sosa, E., Mercado, M., Kopp, P., & Molitch, M. E.
Affiliations
  • Northwestern University (US)
  • Mexican Social Security Institute (MX)
Corresponding author
Molitch, Mark E.
ORCID
Venue
Pituitary
Publisher
Springer Science and Business Media LLC
Published
2003-03
Volume
6
Issue
1
Pages
5-10
ISSN
  • 1386-341X (ISSN-L)
  • 1573-7403
DOI
10.1023/a:1026232124988
OpenAlex
W1560528387
Semantic Scholar
8dc3d05f740d042e564aa7622501688880e8e6ef
Cited by
11
References
40
Citations by year
2023: 1 · 2022: 1 · 2016: 2 · 2012: 1
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pituitary (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
testosterone replacement therapy, male fertility, spermatogenesis, sperm count, gonadotropin levels, azoospermia, semen analysis
MeSH terms
Acromegaly, Adult, Androgens, Fertility, Follicle Stimulating Hormone, Humans, Hypogonadism, Luteinizing Hormone, Male, Middle Aged, Postoperative Complications, Spermatogenesis, Testosterone

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