The DOI matches its Crossref record; 258 of the 259 references it cites were found in a registry or an index.
Peptidases and amino acid catabolism in lactic acid bacteria
Abstract
The conversion of peptides to free amino acids and their subsequent utilization is a central metabolic activity in prokaryotes. At least 16 peptidases from lactic acid bacteria (LAB) have been characterized biochemically and/or genetically. Among LAB, the peptidase systems of Lactobacillus helveticus and Lactococcus lactis have been examined in greatest detail. While there are homologous enzymes common to both systems, significant differences exist in the peptidase complement of these organisms. The characterization of single and multiple peptidase mutants indicate that these strains generally exhibit reduced specific growth rates in milk compared to the parental strains. LAB can also catabolize amino acids produced by peptide hydrolysis. While the catabolism of amino acids such as Arg, Thr, and His is well understood, few other amino acid catabolic pathways from lactic acid bacteria have been characterized in significant detail. Increasing research attention is being directed toward elucidating these pathways as well as characterizing their physiological and industrial significance.
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In the citing paper
“Up until 2003 just 11 peptidases were known to be part of the proteolytic system of L. helveticus: two proline-specific endopepeptidases, PepE and PepO; a tripeptidase PepT; four aminopeptidases, PepX, PepI, PepQ, and PepR; and four dipeptidases, PepD, PepV, PepC, and PepN (Christensen et al., 1999; Savijoki and Palva, 2000; Kenny et al., 2003; Pan and Tanokur, 2004).”
From Lactobacillus helveticus: the proteolytic system (2013) · cites this paper as Christensen et al., 1999
In the citing paper
“Pathways for the catabolism of tryptophan (a), phenylalanine (b) and tyrosine (c), by starter, adjunct and non-starter bacteria (modified from [24]).”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [24]
In the citing paper
“Three different Asp catabolic pathways have been reported [24]; however, the details and distribution of these pathways are still not well understood.”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [24]
In the citing paper
“A common pathway in LAB for the catabolism of Arg results in the conversion of 1 mol of Arg into 2 mol of ammonia and 1 mol each of ornithine, carbon dioxide, and ATP [24].”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [24]
In the citing paper
“The reported pathways of Glu catabolism produce α-ketoglutarate by the action of an aminotransferase or dehydrogenase, or γ-aminobutyrate (GABA) by the action of a decarboxylase [24].”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [24]
In the citing paper
“Catabolism of branched-chain amino acids is typically associated with the generation of compounds having a detrimental effect on product aroma or flavour in the production of fermented dairy products [24].”
From Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review (2000) · cites this paper as [24]
In the citing paper
“Amino acids can be catabolised by several reactions: deamination, decarboxylation, oxidative desamination, transamination and elimination [14,55,67].”
From Production of cheese flavour compounds derived from amino acid catabolism by Propionibacterium freudenreichii (2002) · cites this paper as [14]
In the citing paper
“In general, branched-chain acids appear to be more prevalent in Swisstype cheeses and some Italian cheeses than in semi-hard cheese like Cheddar, Edam and Gouda [9,14,17,55].”
From Production of cheese flavour compounds derived from amino acid catabolism by Propionibacterium freudenreichii (2002) · cites this paper as [14]
Citations
Cites
Escherichia coli and Salmonella :cellular and molecular biology
Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,197
Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology
Neidhardt, F. C., Ingraham, J. L., Low, K. B., Magasanik, B., Schaechter, M., & Umbarger, H. E. (1987) · Cited by 4,097
The PROSITE database, its status in 1995
Bairoch, A., Bücher, P., & Hofmann, K. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.189 · Cited by 1,916
Biogenic amines: their importance in foods.
Santos, M. H. S. (1996) · International Journal of Food Microbiology · doi:10.1016/0168-1605(95)00032-1 · Cited by 1,516
The PROSITE database, its status in 1999
Hofmann, K., Bücher, P., Falquet, L., & Bairoch, A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.215 · Cited by 1,092
Sonenshein, A. L., Hoch, J. A., & Losick, R. M. (1993) · Cited by 1,083
Occurrence and formation of biologically active amines in foods
ten Brink, B., Damink, C., Joosten, H. M. L. J., & Veld, J. H. J. H. I. (1990) · International Journal of Food Microbiology · doi:10.1016/0168-1605(90)90040-c · Cited by 927
Biosynthesis and metabolism of arginine in bacteria
Cunin, R., Glansdorff, N., Pierard, A., & Stalon, V. (1986) · Microbiological Reviews · doi:10.1128/mr.50.3.314-352.1986 · Cited by 831
Teuber, M. (2001) · Wiley eBooks · doi:10.1002/9783527620999.ch10 · Cited by 738
The proteotytic systems of lactic acid bacteria
Kunji, E. R. S., Mierau, I., Hagting, A., Poolman, B., & Konings, W. N. (1996) · Antonie van Leeuwenhoek · doi:10.1007/bf00395933 · Cited by 724
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1 of the 259 references couldn’t be matched to a known paper.
Research works printed but not linked: 17
- Biede SL, Paulsen PV, Hammond EG & Glatz BA (1979) The flavor of Swiss cheese. In: Underkofler LA (Ed) Development in Industrial Microbiology, (pp 203-210). Society for Industrial Microbiology, Arlington, VA
- Bockelmann W, Gollan V & Heller KJ (1997) Purification of a second tripeptidase from Lactobacillus delbrueckii subsp. bulgaricus B14. Milchwissenschaft 52: 500-503
- Christensen JE & Steele JL (1996) Characterization of peptidase-deficient Lactobacillus helveticus CNRZ32 derivatives. Fifth Symposium on Lactic Acid Bacteria, Veldhoven, The Netherlands
- Christensen JE & Steele JL (1998a) Hydrolysis of casein derived peptides by peptidase-deficient Lactobacillus helveticus CNRZ32 derivatives. Joint Meeting of the American Dairy Science Association and the American Society of Animal Science. Journal of Dairy Science, Denver, Colorado, USA.
- Desmazeaud MJ & Zevaco C (1979) Isolation and general properties of two intracellular amino peptidases of Streptococcus diacetylactis. Milchwissenschaft 34: 606-610
- Gummalla S & Broadbent JR (1996) Indole production by Lactobacillus ssp. in cheese: a possible role for tryptophanase. J. Dairy Sci. 79(Suppl. 1): 101
- Guthrie BD (1993) Influence of cheese-related microflora on the production of unclean-flavored aromatic amino acid metabolites in Cheddar cheese. Ph.D thesis, University of Wisconsin-Madison
- Kaminogawa S, Azuma N, Hwang IK, Suzuki Y & Yamauchi K (1984) Isolation and characterization of a prolidase from Streptococcus cremoris H61. Agric. Biol. Chem. 48: 3035-3040
- Kong Y, Strickland M & Broadbent JR (1996) Tyrosine and phenylalanine catabolism by Lactobacillus casei flavor adjuncts: biochemistry and implications in cheese flavor. J. Dairy Sci. 79(Suppl. 1): 101
- Law BA (1981) The formation of aroma and flavor compounds in fermented dairy products. Dairy Sci. Abstr. 43: 143
- Manca de Nadra MC, Pese de Ruiz Holgado AA & Oliver G (1982) Arginine dihydrolase activity in lactic acid bacteria. Milchwissenschaft 37: 669-670
- Manca De Nadra MC, Raya RR, Pesce De Ruiz Holgado A & Oliver G (1987) Isolation and properties of threonine aldolase of Lactobacillus bulgaricus YOP12. Milchwissenschaft 42: 92-94
- Reiter B & Oram JD (1962) Nutritional studies on cheese starters. I. Vitamin and amino acid requirements of single strain starters. J Dairy Res. 29: 63-77
- Shankar PA (1977) Interrelationships of Streptococcus thermophilus and Lactobacillus bulgaricus in yoghurt culture. Thesis, University of Reading, Reading, UK
- Stepaniak L, Gobbetti M & Sorhaug T (1998b) Isolation and characterization of high molecular mass endopeptidase complex from Lactococcus lactis. Milchwissenschaft 53: 255-259
- Yan TR, Lin MZ, Lin MJ & Sun BJ (1991) Purification and characterization of an X-prolyl-dipeptidyl aminopeptidase from Streptococcus cremoris nTR. J. Chin. Biochem. Soc. 20: 21-32
- Zoon P & Allersma D (1996) Eye and crack formation in cheese by carbon dioxide from decarboxylation of glutamic acid. Neth. Milk Dairy J. 50: 309-318
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Sorted by citations
Bioactive peptides: Production and functionality
Korhonen, H. J. T., & Pihlanto, A. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.10.012 · Cited by 1,822
Complete genome sequence of Lactobacillus plantarum WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472
Biochemical pathways for the production of flavour compounds in cheeses during ripening: A review
McSweeney, P. L. H., & Sousa, M. J. (2000) · Le Lait · doi:10.1051/lait:2000127 · Cited by 1,266
Yeast and bacterial modulation of wine aroma and flavour
SWIEGERS, J. H., BARTOWSKY, E. J., HENSCHKE, P. A., & PRETORIUS, I. S. (2005) · Australian Journal of Grape and Wine Research · doi:10.1111/j.1755-0238.2005.tb00285.x · Cited by 1,216
The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403Preprint
Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S. D., & Sorokin, A. (2001) · Genome Research · doi:10.1101/gr.169701 · Cited by 1,161
Metadata
- Authors
- Christensen, J. E., Dudley, E. G., Pederson, J. A., & Steele, J. L.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Steele, James L.
- Venue
- Antonie van Leeuwenhoek
- Published
- 1999-11
- Volume
- 76
- Issue
- 1-4
- Pages
- 217-246
- ISSN
- 0003-6072 (ISSN-L)
- 1572-9699
- OpenAlex
- W1563027263
- Cited by
- 630
- References
- 259
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 18 · 2023: 18 · 2022: 23 · 2021: 14 · 2020: 25 · 2019: 13 · 2018: 20 · 2017: 30 · 2016: 24 · 2015: 24 · 2014: 28 · 2013: 20 · 2012: 32
- FWCI
- 46.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Antonie van Leeuwenhoek (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- proteolytic enzymes, amino acid catabolism, lactic acid bacteria, Lactobacillus helveticus, Lactococcus lactis, peptide hydrolysis, amino acid utilization, arginine catabolism, histidine catabolism
- MeSH terms
- Amino Acid Sequence, Amino Acids, Animals, Gram-Positive Bacteria, Lactobacillus, Peptide Hydrolases, Substrate Specificity, Lactic Acid
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