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Gallbladder Motility and Lithogenesis in Obese Patients During Diet-Induced Weight Loss

Zapata, Rodrigo, Severín, Cecilia, Manríquez, Mónica, Valdivieso, Vicente·2000·Digestive Diseases and Sciences
DOI 10.1023/a:1005497517854
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Abstract

Unlabelled Obesity and weight loss are important risk factors for gallstone development. The mechanisms involved are unknown. We prospectively studied changes in gallbladder (GB) emptying and bile composition during weight loss. We studied 12 alithiasic obese subjects who entered a six-month diet program (800-1200 kcal/day, 26 g fat/day). As controls we evaluated 12 healthy nulliparous nonobese young women. GB volumes were studied by ultrasonography (fasting volume, GBFV; residual volume after a liquid meal, GBRV) at entry and after 4 and 20 weeks of dieting. Bile acid pool size, biliary lipid composition, presence of cholesterol crystals, and nucleation time were also studied. Of 12 obese subjects studied (mean BMI 35.1 kg/m2), 10 remained in the program for six months, but only six completed the entire study protocol, obtaining a significant weight loss (BMI: 31.2 kg/m2, P In conclusion (1) obese subjects had a greater GBFV than controls; however, the GB emptying was adequate. (2) During weight loss we did not observe significant changes in GB kinetics or the bile parameters studied. (3) We observed a relatively low frequency of gallstone formation, which can be explained by a high fat content of the diet (26 g/day) and by the adequate GB emptying of our group of patients. (4) An abnormal GB contractility and cholesterol crystals in bile could be considered premonitory to gallstone formation.

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Metadata

Authors
Zapata, R., Severín, C., Manríquez, M., & Valdivieso, V.
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2000-02
Volume
45
Issue
2
Pages
421-428
ISSN
  • 0163-2116
  • 1573-2568
DOI
10.1023/a:1005497517854
Cited by
25
References
2
Language
en
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