Cited by 46Telomeres, Telomerase, and SenescenceBreast Cancer Treatment StudiesBreast Lesions and Carcinomas

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Telomerase activity in ductal carcinoma in situ of the breast

Shpitz, B., Zimlichman, S., Zemer, R., Bomstein, Y., Zehavi, T., Liverant, S., Bernehim, J., Kaufman, Z., Klein, E., Shapira, Y., Klein, A.pitz·1999·Breast Cancer Research and Treatment

DOI 10.1023/a:1006394209922

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Abstract

Telomerase plays an important role in maintaining the stability of the chromosomes. Activity of telomerase has been detected in proliferating and immortalized cell lines and in a number of malignant tumors including invasive breast cancer. The aim of the study was to examine telomerase activity in ductal carcinoma in situ (DCIS), which is considered to be a precursor lesion of infiltrating breast carcinoma, using a PCR-based telomerase activity protocol (TRAP). We examined 35 samples obtained from histologically confirmed breast biopsies, including 13 normal breast tissues, 11 infiltrating ductal carcinoma (IDC), nine DCIS, and two DCIS with microinvasion. Telomerase activity was demonstrated in 8/9 samples of DCIS, both samples of DCIS with microinvasion, and all but one sample of IDC. Normal breast tissue had no demonstrable telomerase activity. Our results indicate that telomerase is activated frequently in early breast carcinogenesis, although its utilization as a biomarker in DCIS is questionable.

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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“17, 18).”

Authors: Shpitz, B., Zimlichman, S., Zemer, R., Bomstein, Y., Zehavi, T., Liverant, S., Bernehim, J., Kaufman, Z., Klein, E., Shapira, Y., & Klein, A. P.
Venue: Breast Cancer Research and Treatment
Publisher: Springer Science and Business Media LLC
Published: 1999-11
Volume: 58
Issue: 1
Pages: 65-69
ISSN: 0167-6806 (ISSN-L)
1573-7217
DOI: 10.1023/a:1006394209922
OpenAlex: W2072899803
Cited by: 46
References: 33
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 2
FWCI: 1.49
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Breast Cancer Research and Treatment (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
Keywords: telomerase activity, ductal carcinoma in situ, breast cancer, invasive ductal carcinoma, microinvasion, TRAP assay, chromosome stability
MeSH terms: Adult, Aged, Breast, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Female, Humans, Immunohistochemistry, Middle Aged, Neoplasm Invasiveness, Polymerase Chain Reaction, Carcinoma, Ductal, Breast, Telomerase

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Telomerase activity in ductal carcinoma in situ of the breast

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