The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
Abstract
To provide an investigative tool for the study of osteosarcoma (OSA) biology we have developed a syngeneic (balb/c) murine model of OSA, using cell lines derived from a spontaneously occurring murine OSA (Schmidt et al. Differentiation 1988; 39: 151-60). This model is characterized by orthotopic primary tumor growth, a period of minimal residual disease, spontaneous pulmonary metastasis, and clonally related variants (K7M2 and K12) that differ in pulmonary metastatic potential. Primary tumor and pulmonary metastasis histology was consistent with OSA in human patients. Expression of bone sialoprotein, biglyan, decorrin, and osteopontin was suggestive of bone lineage cells. The development and use of a more aggressive OSA cell line (K7M2) resulted in spontaneous metastasis to the lungs in over 90% of mice, whereas metastases were seen in only 33% of mice when a less aggressive OSA cell line (K12; Schmidt et al. Differentiation 1988; 39: 151-60) was used. Death from metastasis occurred at a median of 76 days using K7M2 whereas no median was achieved after 140 days using K12. Angiogenic potential, characterized by CD31 and factor VIII staining of primary tumors and pulmonary metastases, was greater in the K7M2 model compared to the K12 model. No significant differences in the in vitro or in vivo expression of angiogenesis associated genes (flt1, flt4, TIE1, TIE2, and VEGF) was found between K7M2 and K12. This well characterized and relevant model of OSA will be a valuable resource to improve our understanding of the biology and treatment of metastasis in OSA.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Companion cell lines with enhanced lung colonization capacity, such as SaOS2-LM7, MG63.3 and 143B 209,210,211 , have enabled the study of metastasis-driving mechanisms 50,212 .”
From Osteosarcoma (2022) · cites this paper as [210]
In the citing paper
“Cultures derived from mice with spontaneous osteosarcoma 210 or from genetically engineered mouse models 100,213 are available to study disease biology or therapeutics in mice with intact immune systems.”
From Osteosarcoma (2022) · cites this paper as [210]
Citations
Cites
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
OʼReilly, M. (1994) · Cell · doi:10.1016/0092-8674(94)90200-3 · Cited by 3,344
Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry
Maniotis, A. J., Folberg, R., Hess, A. R., Seftor, E. A., Gardner, L. M. G., Pe’er, J., Trent, J. M., Meltzer, P. S., & Hendrix, M. J. C. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65173-5 · Cited by 2,049
The pathogenesis of cancer metastasis
Poste, G. H., & Fidler, I. J. (1980) · Nature · doi:10.1038/283139a0 · Cited by 1,739
Tumor angiogenesis: past, present and the near future
Kerbel, R. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.505 · Cited by 985
Grzesik, W. J., & Robey, P. G. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090408 · Cited by 369
Ferracini, R., Renzo, M. F. D., Scotlandi, K., Baldini, N., Olivero, M., Lollini, P., Cremona, O., Campanacci, M., & Comoglio, P. M. (1995) · PubMed · Cited by 280
Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis
Fidler, I. J. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.21.1588 · Cited by 240
Comparative Aspects of Osteosarcoma
Withrow, S. J., Powers, B. E., Straw, R. C., & Wilkins, R. M. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199109000-00023 · Cited by 239
Angiogenesis Inhibitors Generated by Tumors
Folkman, J. (1995) · Molecular Medicine · doi:10.1007/bf03401559 · Cited by 219
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 207
Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma
Mochizuki, Y., Tazawa, H., Demiya, K., Kure, M., Kondo, H., Komatsubara, T., Sugiu, K., Hasei, J., Yoshida, A., Kunisada, T., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02774-7 · Cited by 30
Apoptosis Resistance and PKC Signaling: Distinguishing Features of High and Low Metastatic Cells
Hong, S.-H., Ren, L., Mendoza, A., Eleswarapu, A. S., & Khanna, C. (2012) · Neoplasia · doi:10.1593/neo.111498 · Cited by 28
Self-citationAnimal models for studying lung cancer and evaluating novel intervention strategies
Liu, J., & Johnston, M. R. (2002) · Surgical Oncology · doi:10.1016/s0960-7404(02)00053-1 · Cited by 29
Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0326 · Cited by 27
Self-citationXue, Y.-L., Meng, X., Ma, L.-J., & Yuan, Z. (2016) · Oncology Letters · doi:10.3892/ol.2016.4725 · Cited by 27
Fan, T. M. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.107 · Cited by 28
Garimella, R., Eskew, J. D., Bhamidi, P., Vielhauer, G. A., Hong, Y., Anderson, H. C., Tawfik, O. W., & Rowe, P. S. (2013) · Journal of bone oncology · doi:10.1016/j.jbo.2012.12.005 · Cited by 26
Grisez, B. T., Ray, J. J., Bostian, P. A., Markel, J., & Lindsey, B. A. (2018) · Journal of Orthopaedic Research® · doi:10.1002/jor.23868 · Cited by 25
Sévère, N., Dieudonné, F., Marty, C., Modrowski, D., Patiño‐García, A., Lecanda, F., Fromigué, O., & Marie, P. J. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1667 · Cited by 26
Targeted Therapies in Bone Sarcomas
Scotlandi, K., Picci, P., & Kovar, H. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909789760410 · Cited by 26
Metastatic Osteosarcoma Gene Expression Differs In Vitro and In Vivo
Lisle, J. W., Choi, J. Y., Horton, J. A., Allen, M. J., & Damron, T. A. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0309-1 · Cited by 27
Pulmonary metastasetomy for osteosarcoma: is it justified?
Diemel, K., Klippe, H. J., & Branseheid, D. (2009) · PubMed · Cited by 24
Sottnik, J. L., Duval, D. L., Ehrhart, E. J., & Thamm, D. H. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9318-z · Cited by 24
ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2
Kumar, R. M. R., Betz, M., Robl, B., Born, W., & Fuchs, B. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-559 · Cited by 25
Bone sarcomas: pathogenesis and new therapeutic approaches
Heymann, D., & Rédiní, F. (2011) · IBMS BoneKEy · doi:10.1138/20110531 · Cited by 26
Smeester, B. A., Al-Gizawiy, M. M., & Beitz, A. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/671386 · Cited by 23
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis
Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Bomberger, H. E., Shamsan, G. A., Peterson, J. J., Crosby, M. R., Draper, G. M., Becklin, K. L., Rahrmann, E. P., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1041-x · Cited by 21
Hennessy, M., Wahba, A., Felix, K., Cabrera, M., Segura, M. G., Kundra, V., Ravoori, M. K., Stewart, J., Kleinerman, E. S., Jensen, V. B., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33382 · Cited by 21
Smeester, B. A., Al-Gizawiy, M. M., O’Brien, E. E., Ericson, M. E., Triemstra, J. L., & Beitz, A. J. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/387169 · Cited by 22
Collier, C. D., Wirtz, E. C., Knafler, G. J., Morris, W. Z., Getty, P. J., & Greenfield, E. M. (2018) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999.0000000000000059 · Cited by 22
Hebron, K. E., Wan, X., Roth, J. S., Liewehr, D. J., Sealover, N. E., Frye, W. J. E., Kim, A., Stauffer, S., Perkins, O. L., Sun, W., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1646 · Cited by 19
Secretion of MCP-1 and other paracrine factors in a novel tumor-bone coculture model
Schiller, K. R., Zillhardt, M., Alley, J. F., Borjesson, D. L., Beitz, A. J., & Mauro, L. J. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-45 · Cited by 20
Arlt, M., Walters, D. K., Banke, I. G. J., Steinmann, P., Puskás, G. J., Bertz, J., Rentsch, K., Ehrensperger, F., Born, W., & Fuchs, B. (2011) · International Journal of Cancer · doi:10.1002/ijc.27378 · Cited by 19
Mandell, J. B., Lu, F., Fisch, M., Beumer, J. H., Guo, J., Watters, R. J., & Weiss, K. R. (2019) · Sarcoma · doi:10.1155/2019/1320201 · Cited by 18
Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma
Kowalczyk, J. T., Wan, X., Hernandez, E. R., Luo, R., Lyons, G. C., Wilson, K. M., Gallardo, D. C., Isanogle, K. A., Robinson, C. M., Mendoza, A., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0525 · Cited by 18
Hong, S., Briggs, J., Newman, R. J., Hoffman, K. E., Mendoza, A., LeRoith, D., Helman, L. J., Yakar, S., & Khanna, C. (2008) · International Journal of Cancer · doi:10.1002/ijc.24169 · Cited by 18
Self-citationErbB3 silencing reduces osteosarcoma cell proliferation and tumor growth in vivo
Jullien, N. D., Dieudonné, F., Habel, N., Marty, C., Modrowski, D., Patiño‐García, A., Lecanda, F., Sévère, N., & Marie, P. J. (2013) · Gene · doi:10.1016/j.gene.2013.03.031 · Cited by 17
Dutour, A., Leclers, D., Monteil, J., Paraf, F., Charissoux, J.-L., Rousseau, R. F., & Rigaud, M. (2007) · PubMed · Cited by 17
Chick Embryo Extract Demethylates Tumor Suppressor Genes in Osteosarcoma Cells
Mu, X., Sultankulov, B., Agarwal, R., Mahjoub, A., Schott, T., Greco, N., Huard, J., & Weiss, K. R. (2013) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-013-3104-6 · Cited by 17
Jaroensong, T., Endo, Y., Lee, S. ‐., Kamida, A., Mochizuki, M., Nishimura, R., Sasaki, N., & Nakagawa, T. (2011) · Veterinary and Comparative Oncology · doi:10.1111/j.1476-5829.2011.00294.x · Cited by 16
Quantifying intra‐osseous growth of osteosarcoma in a murine model with radiographic analysis
Cole, H., Ichikawa, J., Colvin, D. C., O’Rear, L., & Schoenecker, J. G. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21474 · Cited by 16
Crasto, J. A., Fourman, M. S., Morales-Restrepo, A., Mahjoub, A., Mandell, J. B., Ramnath, K., Tebbets, J. C., Watters, R. J., & Weiss, K. R. (2018) · Oncotarget · doi:10.18632/oncotarget.25733 · Cited by 17
Griffin, K. H., Thorpe, S. W., Sebastian, A., Hum, N. R., Coonan, T. P., Sagheb, I. S., Loots, G. G., Randall, R. L., & Leach, J. K. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302101120 · Cited by 15
Liu, T., Ma, Q., Zhang, Y., Shi, K., Yan, K., Chen, X. '., Wen, Y., Fan, Q., & Qiu, X. (2014) · Tumor Biology · doi:10.1007/s13277-014-2844-6 · Cited by 15
Ren, L., Huang, S., Beck, J. A., & LeBlanc, A. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-04018-9 · Cited by 13
Metastatic Hepatocarcinoma He/De Tumor Model in Rat
Trencsényi, G., Márián, T., Bako, F., Emri, M., Nagy, G., Kertai, P., & Bánfalvi, G. (2014) · Journal of Cancer · doi:10.7150/jca.9315 · Cited by 13
Evaluation of F8-TNF-α in Models of Early and Progressive Metastatic Osteosarcoma
Robl, B., Botter, S. M., Boro, A., Meier, D., Neri, D., & Fuchs, B. (2017) · Translational Oncology · doi:10.1016/j.tranon.2017.02.005 · Cited by 13
Roberts, B. K., Li, D. I., Somerville, C. C., Matta, B., Jha, V. J., Steinke, A. M., Brune, Z., Blanc, L., Soffer, S. Z., & Barnes, B. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-66168-w · Cited by 15
A novel noninvasive method for evaluating experimental lung metastasis in mice.
Mendoza, A., Gharpure, R. V., Dennis, J. U., Webster, J. D., Smedley, J. V., & Khanna, C. (2013) · Europe PMC (PubMed Central) · Cited by 12
Self-citationDu, L., Fan, Q., Tu, B., Yan, W., & Tang, T. (2014) · PubMed Central · Cited by 11
The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets
Belayneh, R., & Weiss, K. R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43085-6_10 · Cited by 11
Zalacaín, M., Buñuales, M., Marrodán, L., Labiano, S., González-Huarriz, M., Martínez-Vélez, N., Laspidea, V., Puigdelloses, M., García-Moure, M., González-Aparicio, M., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.11.003 · Cited by 9
B7-H3 protein expression in a murine model of osteosarcoma
ZHAO, J.-L., Chen, F., Zhou, Q., Pan, W. X., WANG, X.-H., Xu, J. Y., ZHANG, S.-X., Li, N., & Yang, H. (2016) · Oncology Letters · doi:10.3892/ol.2016.4675 · Cited by 10
Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis
Cates, J., Friedman, D. B., Seeley, E. H., Dupont, W. D., Schwartz, H. S., Holt, G. E., Caprioli, R. M., & Young, P. P. (2010) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2010.00711.x · Cited by 10
Sorenson, B. S. (2010) · Biologics · doi:10.2147/btt.s9121 · Cited by 10
Ringwalt, E. M., Currier, M. A., Glaspell, A. M., Chen, C., Cannon, M. V., Cam, M., Gross, A. C., Gust, M. J., Wang, P.-Y., Boon, L., et al. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200886 · Cited by 9
Mammalian models of bone sarcomas
Botter, S. M., Arlt, M., Born, W., & Fuchs, B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00030-3 · Cited by 10
Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas
Trihia, H., & Valavanis, C. (2012) · InTech eBooks · doi:10.5772/31431 · Cited by 9
Tattersall, L., Davison, Z., & Gartland, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62259-6 · Cited by 10
Bencze, N., Scheich, B., Szőke, É., Wilhelm, I., Körmöndi, S., Botz, B., & Helyes, Z. (2024) · Cancers · doi:10.3390/cancers16101788 · Cited by 8
Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
Byrgazov, K., Anderson, C. N., Salzer, B., Bozsaky, E., Larsson, R. L., Gullbo, J., Lehner, M., Lehmann, F., Slipicevic, A., Kager, L., et al. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920937891 · Cited by 8
Pearce, S. M., Cross, N. A., Smith, D. P., Clench, M. R., Flint, L., Hamm, G. R., Goodwin, R. J. A., Langridge, J., Claude, E., & Cole, L. M. (2024) · Metabolites · doi:10.3390/metabo14060315 · Cited by 7
Targetable Intercellular Signaling Pathways Facilitate Lung Colonization in Osteosarcoma
Reinecke, J. B., & Roberts, R. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43085-6_7 · Cited by 7
Ishiyama, S., Kissel, C. L., Guo, X., Howard, A., Saeki, H., Ito, T., Sysa‐Shah, P., Orita, H., Sakamoto, K., & Gabrielson, K. L. (2021) · Journal of Visualized Experiments · doi:10.3791/62139 · Cited by 6
Janeway, K. A., Gorlick, R. G., & Bernstein, M. L. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3431-5.00022-4 · Cited by 6
Sagheb, I. S., Coonan, T. P., Randall, R. L., Griffin, K. H., & Leach, J. K. (2024) · Cancer Medicine · doi:10.1002/cam4.70239 · Cited by 5
Guo, Z., Zou, Y., Liao, Y., Chen, J., Chen, W., Tu, J., Wen, L. Q., Yao, H., & Xie, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116110 · Cited by 5
Barghi, F., Saadatzadeh, M. R., Dobrota, E. A., Shannon, H. E., Bailey, B. J., Young, C., Malko, R., Justice, R. E., Riyahi, N., Davis, C. M., et al. (2026) · Neoplasia · doi:10.1016/j.neo.2025.101266 · Cited by 6
Fischer, S., Creytens, D., Geyter, S. D., Vlieghere, E. D., Pattyn, P., Bekaert, S.-L., Durinck, K., Roy, N. V., Hendrix, A., Lapeire, L., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1290 · Cited by 5
Salinas-Souza, C., Oliveira, I. D., de Oliveira, R., Alves, M. T. D. S., Petrilli, A. S., & de Toledo, S. R. C. (2012) · Cytotechnology · doi:10.1007/s10616-012-9487-5 · Cited by 5
Long, S. A., Huang, S., Kambala, A., Ren, L., Wilson, J. A., GOETZ, M. A., Hao, X., Yang, X., Goncharova, E. I., Jia, L., et al. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13762 · Cited by 5
Self-citationMacrophage and osteosarcoma cell crosstalk is dependent on oxygen tension and 3D culture
Griffin, K. H., Sagheb, I. S., Coonan, T. P., Fierro, F. A., Randall, R. L., & Leach, J. K. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214154 · Cited by 4
Lu, J., Jiang, R., Xu, X., & Shen, J. (2024) · Biomedicines · doi:10.3390/biomedicines12071513 · Cited by 4
Gene and Virotherapy Against Osteosarcoma
Ketola, A. (2009) · Cited by 4
Sunbul, F. S., Almuqbil, R. M., Zhang, H., Alhudaithi, S. S., Fernandez, M. E., Aldaqqa, R. R., Garcia, V. A., Robila, V., Halquist, M. S., Gordon, S. W., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125372 · Cited by 3
Murine and Canine Models of Appendicular Osteosarcoma
Fan, T. M. (2007) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph1401s37 · Cited by 3
Osteosarcoma: mouse models, cell of origin and cancer stem cell
Guijarro, M. V. (2014) · Postdoc Journal · doi:10.14304/surya.jpr.v2n2.3 · Cited by 3
Uskoković, V. (2026) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2026.184506 · Cited by 2
Fischer, S., Creytens, D., Gijsels, S., Descamps, B., Lapeire, L., Hendrix, A., Sys, G. M. L., & Wever, O. D. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.102863 · Cited by 2
Gill, K. S., Fernandes, P., Bird, B., Soden, D. M., & Forde, P. F. (2018) · Oncotarget · doi:10.18632/oncotarget.25843 · Cited by 2
STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcomaPreprint
Young, E. P., Johnson, C. A., Lee, A. G., Morris, D., Tsui, J. L., Breese, M. R., Cámara, J. A., Schott, C. R., Abram, C. L., Leung, S. G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684275 · Cited by 2
Hay, A. N., Simon, A., Ruger, L. N., Gannon, J., Coutermarsh‐Ott, S. L., Vickers, E., Eward, W. C., Neufeld, N. J., Vlaisavljevich, E., & Tuohy, J. L. (2025) · Biomedicines · doi:10.3390/biomedicines13092122 · Cited by 1
Yi, X., Tao, J., Chen, Y., Yuan, Y., Teng, Z., Li, P., & Yu, A. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168995 · Cited by 1
Roudi, R., Habte, F. G., Saladino, G. M., Vasyliv, I., Pisani, L. J., Wong, J., Syed, A., & Daldrup-Link, H. E. (2026) · Scientific Reports · doi:10.1038/s41598-026-56539-w · Cited by 1
Nanostructured selenium anti-cancer coatings for orthopedic applications
Tran, P. A., & Webster, T. J. (2012) · Elsevier eBooks · doi:10.1533/9780857096449.2.180 · Cited by 1
Modeling osteosarcoma: in vitro and in vivo approaches
Walkley, C. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00017-0 · Cited by 2
Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches
Rousseau, J., Lamoureux, F., Picarda, G. G. A., Gouin, F., Trichet, V., & Rédiní, F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374895-9.00028-1 · Cited by 2
Repurposing riluzole as an anti-osteosarcoma agent
Jung, O., Rajasekhar, V. K., Azeem, S. M., ChandThakuri, S., Norton, B., Healey, J. H., & Mahajan, S. S. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1508819 · Cited by 1
Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?
Ricafort, R. J., & Gorlick, R. G. (2010) · Springer eBooks · doi:10.1007/978-0-387-69062-9_21 · Cited by 1
Masha, A., Ben, G.-P. N., Cohen, E. I., Yvonne, V., & Vago, R. (2020) · Open Journal of Orthopedics and Rheumatology · doi:10.17352/ojor.000025 · Cited by 1
Drug Discovery in Pediatric Bone and Soft Tissue Sarcomas Using In Vivo Models
Peterson, J. K., & Houghton, P. J. (2005) · Springer eBooks · doi:10.1007/3-540-29447-3_5 · Cited by 1
Molecular and cellular mechanisms of osteosarcoma metastasis: current knowledge and perspectives
Fuchs, B., & Born, W. (2009) · Current Orthopaedic Practice · doi:10.1097/bco.0b013e3181ae67c2 · Cited by 1
Positively Selected Enhancer Elements Endow Tumor Cells with Metastatic CompetencePreprint
Morrow, J. J., Bayles, I., Funnell, A. P. W., Miller, T. E., Saiakhova, A., Lizardo, M. M., Bartels, C. F., Kapteijn, M. Y., Hung, S., Mendoza, A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/155416 · Cited by 1
Self-citationSeiden, E. E., Richardson, S. M., Everitt, L. A., Knafler, G. J., Kinsella, G. P., Walker, A. L., Whiteside, V. A., Buschbach, J. D., Gandhi, D. A., Saadatzadeh, M. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.654354 · Cited by 1
Haematogenous Models of Metastases
Logan, P. T. (2013) · Springer eBooks · doi:10.1007/978-1-4614-3685-0_15
Effects of electroacupuncture in a mouse model of experimentally-induced osteosarcoma.
Al-Gizawiy, M. M. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors
Loeb, D. M., & Chen, A. R. (2009) · doi:10.1002/9781444303537.ch67
Laboratory Models of Lung Cancer
Liu, J., & Johnston, M. R. (2006) · Springer eBooks · doi:10.1007/3-540-31040-1_4
Granero‐Moltó, F. (2015) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-015-4423-6
Molecular Pathology of Bone and Soft Tissue Tumors
Ordóñez, J. L., Osuna, D., Madoz‐Gúrpide, J., & de Álava, E. (2016) · Springer eBooks · doi:10.1007/978-1-59745-458-2_34
Purinergic signalling in osteosarcoma
Tattersall, L. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Jaroensong, T. (2011) · Institutional Repositories DataBase (IRDB) · doi:10.15083/00005502
Bánfalvi, G. (2013) · Springer eBooks · doi:10.1007/978-94-007-7335-6_5
Lahr, C. A. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.207759
Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors
Hayashi, M., Loeb, D. M., & Chen, A. R. (2015) · doi:10.1002/9781118416426.ch64
Tumor characterization using the backscatter coefficient at low and high-frequency
Malinet, C., Mansilla, C., Fajnorovà, I., Rohfritsch, A., Melodelima, D., Dutour, A., & Muleki-Seya, P. (2024) · IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS) · doi:10.1109/uffc-js60046.2024.10793991
Pre-clinical Murine Models of Bone Sarcomas
Muñoz-García, J., Vargas-Franco, J. W., Grigoriadis, A. E., Lézot, F., & Heymann, D. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4306-8_20
Metadata
- Authors
- Khanna, C., Prehn, J., Yeung, C., Caylor, J., Tsokos, M., & Helman, L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Clinical & Experimental Metastasis
- Published
- 2000-05
- Volume
- 18
- Issue
- 3
- Pages
- 261-271
- ISSN
- 0262-0898 (ISSN-L)
- 1573-7276
- OpenAlex
- W19745091
- Cited by
- 207
- References
- 42
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 8 · 2014: 14 · 2013: 15 · 2012: 11
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinical & Experimental Metastasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Veterinary › Small Animals › Veterinary Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- osteosarcoma, orthotopic tumor model, syngeneic murine model, lung metastasis, tumor angiogenesis, CD31, factor VIII, vascular endothelial growth factor, bone sialoprotein, osteopontin, biglycan, decorin, metastatic potential
- MeSH terms
- Animals, Bone Neoplasms, Female, Lung Neoplasms, Mice, Inbred BALB C, Models, Biological, Osteosarcoma, Survival Analysis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review