Helman, Lee J.

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, S. M., & Helman, L. J. (2004) · Nature Medicine

Sarcoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 705

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

Janeway, K. A., Kim, S. Y., Lodish, M., Nosé, V., Rustin, P., Gaal, J., Dahia, P. L. M., Liegl, B., Ball, E. R., Raygada, M., et al. (2011) · Proceedings of the National Academy of Sciences

Gastrointestinal Tumor Research and TreatmentGenetic factors in colorectal cancer

Cited by 628

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor

Killian, J. K., Kim, S. Y., Miettinen, M., Smith, C., Merino, M., Tsokos, M., Quezado, M., Smith, W. I., Jahromi, M. S., Xekouki, P., et al. (2013) · Cancer Discovery

Epigenetics and DNA MethylationGastrointestinal Tumor Research and Treatment

Cited by 356

An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential

Khanna, C., Prehn, J., Yeung, C., Caylor, J., Tsokos, M., & Helman, L. (2000) · Clinical & Experimental Metastasis

Sarcoma Diagnosis and TreatmentVeterinary Oncology Research

Cited by 207

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

Tsai, Y. C., Mendoza, A., Mariano, J. M., Zhou, M., Kostova, Z., Chen, B., Veenstra, T., Hewitt, S. M., Helman, L. J., Khanna, C., et al. (2007) · Nature Medicine

Mechanisms of cancer metastasisUbiquitin and proteasome pathways

Cited by 186

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)

Kummar, S., O'Sullivan Coyne, G., Do, K. T., Turkbey, B., Meltzer, P. S., Polley, E., Choyke, P. L., Meehan, R., Vilimas, R., Horneffer, Y., et al. (2017) · Journal of Clinical Oncology

Soft tissue tumor case studiesNeurofibromatosis and Schwannoma Cases

Cited by 183

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

Khanna, C., Fan, T. M., Gorlick, R., Helman, L. J., Kleinerman, E. S., Adamson, P. C., Houghton, P. J., Tap, W. D., Welch, D. R., Steeg, P. S., et al. (2014) · Clinical Cancer Research

Sarcoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 178

Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Morrow, J. J., Bayles, I., Funnell, A. P. W., Miller, T. E., Saiakhova, A., Lizardo, M. M., Bartels, C. F., Kapteijn, M. Y., Hung, S., Mendoza, A., et al. (2018) · Nature Medicine

Genomics and Chromatin DynamicsCancer Cells and Metastasis

Cited by 161

Targeting cancer metabolism

Teicher, B. A., Linehan, W. M., & Helman, L. J. (2012) · Clinical Cancer Research

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 152

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., et al. (2016) · Science Translational Medicine

Veterinary Oncology ResearchScience, Research, and Medicine

Cited by 147

Targeting the insulin growth factor receptor 1

Arnaldez, F. I., & Helman, L. J. (2012) · Hematology/Oncology Clinics of North America

Growth Hormone and Insulin-like Growth FactorsFibroblast Growth Factor Research

Cited by 88

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

Lizardo, M. M., Morrow, J. J., Miller, T. E., Hong, E. S., Ren, L., Mendoza, A., Halsey, C. H., Scacheri, P. C., Helman, L. J., & Khanna, C. (2016) · Neoplasia

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 50

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors

Boikos, S. A., Helman, L. J., & Stratakis, C. A. (2014) · New England Journal of Medicine

Gastrointestinal Tumor Research and TreatmentNeuroendocrine Tumor Research Advances

Cited by 24