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Cited by 106

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Randomized, Double-Blind Placebo-Controlled Trial of Coenzyme Q10 in Patients with Acute Myocardial Infarction

Singh, Ram B., Wander, Gurpreet S., Rastogi, Amit, Shukla, Pradeep K., Mittal, Adarsh, Sharma, Jagdish P., Mehrotra, Shiv K., Kapoor, Raj, Chopra, Raj K.·1998·Cardiovascular Drugs and Therapy
DOI 10.1023/a:1007764616025
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Abstract

The effects of oral treatment with coenzyme Q10 (120 mg/d) were compared for 28 days in 73 (intervention group A) and 71 (placebo group B) patients with acute myocardial infarction (AMI). After treatment, angina pectoris (9.5 vs. 28.1), total arrhythmias (9.5% vs. 25.3%), and poor left ventricular function (8.2% vs. 22.5%) were significantly (P < 0.05) reduced in the coenzyme Q group than placebo group. Total cardiac events, including cardiac deaths and nonfatal infarction, were also significantly reduced in the coenzyme Q10 group compared with the placebo group (15.0% vs. 30.9%, P < 0.02). The extent of cardiac disease, elevation in cardiac enzymes, and oxidative stress at entry to the study were comparable between the two groups. Lipid peroxides, diene conjugates, and malondialdehyde, which are indicators of oxidative stress, showed a greater reduction in the treatment group than in the placebo group. The antioxidants vitamin A, E, and C and beta-carotene, which were lower initially after AMI, increased more in the coenzyme Q10 group than in the placebo group. These findings suggest that coenzyme Q10 can provide rapid protective effects in patients with AMI if administered within 3 days of the onset of symptoms. More studies in a larger number of patients and long-term follow-up are needed to confirm our results.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1007764616025

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 8

  1. Herzog WR, Schlossberg ML, Mortensen SA, Serebruany VL. Dietary supplementation with coenzyme Q10 reduces platelet aggregability in swine Coenzyme Q. Res Biol Med 1995;3:5-8.
  2. Hofman-Bang C, Rehnqvist N, Swedberg K, Astrom H. Coenzyme Q10 as an adjunctive in treatment of congestive heart failure. J Am Coll Cardiol 1992;19(Suppl.):774-776.
  3. Takasawa K, Fuse K, Konishi T, Watanabe Y. Prevention of premature ventricular contractions with coenzyme Q10 after coronary artery bypass grafting. In: Folkers K, Littami GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q. Vol. 6, Amsterdam: Elsevier 1991:357-359.
  4. Brubacher G, Vuillenmier JP, Incurtis HC, Roth M, eds. Vitamin C: Clinical Biochemistry, Principles and Methods, Vol. 2. Berlin: de Gruyter, 1974:989-997.
  5. Schardr F, Welzel D, Schess W, Toda K. Effect of coenzyme Q10 on ischemia-induced ST-segment depression: A double blind, placebo controlled crossover study. In: Folkers K, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q10, Vol. 5. Amsterdam: Elsevier, 1986:385-394.
  6. Rosi E, Lombardo A, Testa M, et al. Coenzyme Q10 in ischaemic cardiopathy. In: Folkers K, Littarru GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 6. Amsterdam: Elsevier, 1991:321-326.
  7. Wilson MF, Frishman WH, Giles T, Sethi G, Greenberg SM, Brackett DJ. Coenzyme Q10 therapy and exercise duration in stable angina. In: Folkers K, Littami GP, Yamagami T, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 6. Amsterdam: Elsevier, 1991:339-348.
  8. Kagan V, Packer L. Electron transport regenerates vitamin E in mitochandria and microsomes via ubiquinone: An antioxidant aduct. In: Corogni F, Banni S, Desai MA, Rice-Evans C, eds. Free Radicals and Antioxidants and Nutrition. London: Richelieu Press, 1993:27-36.

Cited by

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Metadata

Authors
Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., & Chopra, R. K.
Venue
Cardiovascular Drugs and Therapy
Publisher
Springer Science and Business Media LLC
Published
1998-09
Volume
12
Issue
4
Pages
347-353
ISSN
  • 0920-3206
  • 1573-7241
DOI
10.1023/a:1007764616025
Cited by
106
References
27
Language
en
Licence

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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