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Cited by 26Kidney Stones and Urolithiasis TreatmentsCoenzyme Q10 studies and effectsAcute Kidney Injury Research

The protective role of coenzyme Q 10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

Carrasco, Julia, Anglada, Francisco J., Campos, Juan P., Muntané, Jordi, Requena, Maria J., Padillo, Javier·2014·BJU International
DOI 10.1111/bju.12485
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Abstract

Objective: To determine the efficacy of coenzyme Q 10 ( CoQ10 ) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy ( ESWL ). Patients and Methods: Prospective, randomised, double‐blind, placebo‐controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL . The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after. Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index ( VRI ) using D oppler ultrasound were evaluated the week before ESWL , 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL . Results: There was a significant increase in glomerular filtration ( P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β 2 ‐microglobulin level ( P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow‐up after ESWL . The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow‐up period. However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion: Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL .

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  • In patients with renal lithiasis, coenzyme Q10 for 1 week significantly improved glomerular filtration and decreased albumin/creatinine ratio and β2-microglobulin levels.

    “A significant improvement in glomerular filtration and a decrease in the albumin/creatinine ratio and β2-microglobulin levels have been observed in the group taking coenzyme Q10 for 1 week.”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Carrasco et al. 2014

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Authors
Carrasco, J., Anglada, F. J., Campos, J. P., Muntané, J., Requena, M. J., & Padillo, J.
Affiliations
  • Department of Urology Reina Sofia University Hospital Cordoba Spain
  • Hospital Universitario Reina Sofía (ES)
  • Instituto de Salud Carlos III (ES)
  • Department of General Surgery Virgen del Rocio University Hospital/IBiS/CSIC/University of Seville Seville Spain
ORCID
Venue
BJU International
Publisher
Wiley
Published
2014-01-29
Volume
113
Issue
6
Pages
942-950
ISSN
  • 1464-4096 (ISSN-L)
  • 1464-410X
DOI
10.1111/bju.12485
OpenAlex
W1603971276
Cited by
26
References
40
Citations by year
2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 2 · 2014: 2 · 2013: 1
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • British Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Kidney Stones and Urolithiasis Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Keywords
coenzyme Q10, extracorporeal shock wave lithotripsy, kidney injury, kidney stones, antioxidants, renal function, vasoactive hormones, vascular resistance index, interleukins, oxidative stress, glomerular filtration, albuminuria, beta2-microglobulin
MeSH terms
Double-Blind Method, Female, Humans, Kidney, Kidney Calculi, Lithotripsy, Male, Middle Aged, Prospective Studies, Ubiquinone, Vitamins, Wounds and Injuries

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