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Cited by 340Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiovascular and Diving-Related Complications

The DOI matches its Crossref record; 74 of the 76 references it cites were found in a registry or an index.

Clinical Relevance of Silent Atrial Fibrillation: Prevalence, Prognosis, Quality of Life, and Management

Savelieva, Irina, Camm, A. John·2000·Journal of Interventional Cardiac Electrophysiology
DOI 10.1023/a:1009823001707
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Abstract

Although first described about 100yr ago, atrial fibrillation (AF) is now recognized as the most common of all arrhythmias. It has a substantial morbidity and presents a considerable health care burden. Improved diagnosis and an ageing population with an increased likelihood of underlying cardiac disease results in AF in more than 1% of population. AF is associated with an approximately two-fold increase in mortality, largely due to stroke which occurs at an annual rate of 5-7%. Another risk to survival is heart failure, which is aggravated by poor control of the ventricular rate during AF. Usually AF is associated with a variety of symptoms: palpitations, dyspnea, chest discomfort, fatigue, dizziness, and syncope. Paroxysmal AF is likely to be symptomatic and frequently presents with specific symptoms, while permanent AF is usually associated with less specific symptoms. However, in at least one third of patients, no obvious symptoms or noticeable degradation of quality of life are observed. This asymptomatic, or silent, AF is diagnosed incidentally during routine physical examinations, pre-operative assessments or population surveys. Recently, a very large incidence of generally short paroxysms of AF has been seen in patients with implantable pacemakers or defibrillators and these arrhythmias are often silent. Pharmacological suppression of arrhythmia may be associated with a conversion from a symptomatic to an asymptomatic form of AF. Holter monitoring and transtelephonic monitoring studies have demonstrated that asymptomatic episodes of AF exceed symptomatic paroxysms by twelve-fold or more. Although symptoms may not stem directly from AF, the risk of complications is probably the same for symptomatic and asymptomatic patients. AF is found incidentally in about 25% of admissions for a stroke. Studies in patients with little or no awareness of their arrhythmia condition indicate that unrecognized and untreated AF may cause congestive heart failure. In patients with coronary bypass, AF may not only represent risk for immediate postoperative morbidity and increase hospital resource utilization, but being unrecognized, may produce a significant impact on long-term survival and quality of life. Although silent AF merits consideration for anticoagulation and rate control therapy according to standard criteria, whether antiarrhythmic therapy is relevant in this condition remains unclear.

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Crossref · 10.1023/a:1009823001707

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Research works printed but not linked: 6

  1. Garrigue S, Cazeau S, Ritter P, Lazarus A, Gras D, Mugica J. [Incidence of atrial arrhythmias in patients with dual-chamber pacemakers: value of the pacemaker Holter function] [French]. Arch Mal Coeur Vas 1996;89:873-881.
  2. Lombardi F, Tozillo D, Cappiello E. Sympatho-vagal influence in atrial fibrillation. N Trends Arrhythmias 1993;9:179-184.
  3. Feinberg WM, Seeger JF, Carmody RF, Anderson DC, Hart RG, Pearce LA. Asymptomatic cerebral infarction in patients with atrial fibrillation. Circulation 1988;19:955-957.
  4. Kulbertus HE, de Leval-Rutten F, Bartsch P, Petit JM. Atrial fibrillation in elderly, anbulatory patients. In: Kulbertus HE, Olsson SB, Schlepper M, eds. Atrial fibrillation. Mölndal: AB Hässle, 1982:148-157.
  5. Howes CJ, Brandt C, Yerkey MW, Ruo B, Reid C, Ezekowitz MD. Quality of life and exercise tolerance in elderly, ambulatory patients with chronic atrial fibrillation. Circulation 1998;98(Suppl):I-703-I-704 (abstr).
  6. Paquette M, Roy D, Talajic M, Newman D, Dorian P, for the CTAF Investigators. Sinus rhythm at the time of assessment is associated with better quality of life than atrial fibrillation or flutter results from the Canadian Trial of Atrial Fibrillation. PACE 1999;22: 863(abstr).

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Metadata

Authors
Savelieva, I., & Camm, A. J.
Affiliations
St George's, University of London (GB)
Venue
Journal of Interventional Cardiac Electrophysiology
Publisher
Springer Science and Business Media LLC
Published
2000-06
Volume
4
Issue
2
Pages
369-382
ISSN
  • 1383-875X (ISSN-L)
  • 1572-8595
DOI
10.1023/a:1009823001707
OpenAlex
W107386444
Cited by
339
References
76
Citations by year
2026: 4 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 9 · 2020: 18 · 2019: 20 · 2018: 24 · 2017: 21 · 2016: 23 · 2015: 21 · 2014: 18 · 2013: 12 · 2012: 19
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Interventional Cardiac Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Keywords
silent atrial fibrillation, asymptomatic atrial fibrillation, atrial fibrillation prevalence, atrial fibrillation prognosis, quality of life, stroke risk, heart failure, ventricular rate control, antiarrhythmic therapy, anticoagulation, cardiac implantable electronic devices, Holter monitoring, transtelephonic monitoring, coronary artery bypass grafting, mortality
MeSH terms
Atrial Fibrillation, Humans, Prognosis, Quality of Life, Prevalence

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