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Cited by 265Mitochondrial Function and PathologyAutophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

Mitochondrial Involvement in Brain Function and Dysfunction: Relevance to Aging, Neurodegenerative Disorders and Longevity

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Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., Clark, J. B.·2001·Neurochemical Research
DOI 10.1023/a:1010955807739
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Abstract

It is becoming increasingly evident that the mitochondrial genome may play a key role in neurodegenerative diseases. Mitochondrial dysfunction is characteristic of several neurodegenerative disorders, and evidence for mitochondria being a site of damage in neurodegenerative disorders is partially based on decreases in respiratory chain complex activities in Parkinson's disease, Alzheimer's disease, and Huntington's disease. Such defects in respiratory complex activities, possibly associated with oxidant/antioxidant balance perturbation, are thought to underlie defects in energy metabolism and induce cellular degeneration. Efficient functioning of maintenance and repair process seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of genes termed vitagenes. A promising approach for the identification of critical gerontogenic processes is represented by the hormesis-like positive effect of stress. In the present review, we discuss the role of energy thresholds in brain mitochondria and their implications in neurodegeneration. We then review the evidence for the role of oxidative stress in modulating the effects of mitochondrial DNA mutations on brain age-related disorders and also discuss new approaches for investigating the mechanisms of lifetime survival and longevity.

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Research works printed but not linked: 2

  1. Altmann, B. 1894. Cited in: E. de Robertis, W. Nowinski, F. Saez (eds.), Cell Biology, W. B. Saunders, Philadelphia, 1970, pp 199–228.
  2. Cottrell, D. A. and Turnbull, D. M. 2000. Mitochondria and ageing. Curr. Opin. Clin. Nutr. Metab. Care 3:473–478. · DOI

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Metadata

Authors
Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B.
Affiliations
  • University of Catania (IT)
  • UCL Queen Square Institute of Neurology (GB)
ORCID
Venue
Neurochemical Research
Publisher
Springer Science and Business Media LLC
Published
2001-06
Volume
26
Issue
6
Pages
739-764
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
DOI
10.1023/a:1010955807739
OpenAlex
W1595816980
Cited by
263
References
196
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 1 · 2018: 5 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 16
FWCI
5.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
mitochondrial dysfunction, neurodegenerative diseases, brain aging, longevity, Parkinson's disease, Alzheimer's disease, Huntington's disease, respiratory chain complexes, oxidative stress, mitochondrial DNA mutations, energy metabolism, vitagenes, hormesis, stress response, brain mitochondria
MeSH terms
Aging, Animals, Brain, Humans, Longevity, Mitochondria, Neurodegenerative Diseases

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