Calcium and neurodegeneration

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433 · see citing works

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Bence, N., Sampat, R. M., & Kopito, R. R. (2001) · Science · doi:10.1126/science.292.5521.1552 · Cited by 2,192 · see citing works

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works

Molecular Pathways of Neurodegeneration in Parkinson's Disease

Dawson, T. M., & Dawson, V. L. (2003) · Science · doi:10.1126/science.1087753 · Cited by 1,659 · see citing works

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works

UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144244 · Cited by 1,371 · see citing works

Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000159740.16984.3c · Cited by 1,329 · see citing works

MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

Moore, D. J., West, A. B., Dawson, V. L., & Dawson, T. M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135718 · Cited by 1,274 · see citing works

Mitochondria and calcium: from cell signalling to cell death

Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261 · see citing works

NMDA-dependent superoxide production and neurotoxicity

Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

Miller, R. G., Mitchell, J. D., & Moore, D. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001447.pub3 · Cited by 1,123 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

Ageing and neuronal vulnerability

Mattson, M. P., & Magnus, T. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1886 · Cited by 1,075 · see citing works

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981 · see citing works

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912 · see citing works

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works

ER stress and neurodegenerative diseases

Lindholm, D., Wootz, H., & Korhonen, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401778 · Cited by 882 · see citing works

Expanding insights of mitochondrial dysfunction in Parkinson's disease

Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869 · see citing works

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works

Cognitive Reserve and Alzheimer Disease

Stern, Y. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213815.20177.19 · Cited by 838 · see citing works

Oxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases

Floyd, R. A., & Hensley, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00019-2 · Cited by 830 · see citing works

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

Arundine, M., & Tymianski, M. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00141-6 · Cited by 827 · see citing works

Calcium in Ischemic Cell Death

Kristián, T., & Siesjö, B. K. (1998) · Stroke · doi:10.1161/01.str.29.3.705 · Cited by 825 · see citing works

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132197599 · Cited by 824 · see citing works

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I. M., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 795 · see citing works

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010255.x · Cited by 781 · see citing works

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 731 · see citing works

Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75

Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P. A., & Barde, Y. (1996) · Science · doi:10.1126/science.272.5261.542 · Cited by 653 · see citing works

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

Barger, S. W., Hörster, D., Furukawa, K., Goodman, Y., Krieglstein, J., & Mattson, M. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9328 · Cited by 625 · see citing works

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca 2+ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

Mattson, M. P., Lovell, M. A., Furukawa, K., & Markesbery, W. R. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041740.x · Cited by 615 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

Sherer, T., Betarbet, R. S., Stout, A. K., Lund, S. A., Baptista, M. J., Panov, A. V., Cookson, M., & Greenamyre, J. T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07006.2002 · Cited by 581 · see citing works

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

Mark, R. J., Hensley, K., Butterfield, D. A., & Mattson, M. P. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06239.1995 · Cited by 553 · see citing works

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

Mark, R. J., Pang, Z., Geddes, J. W., Uchida, K., & Mattson, M. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01046.1997 · Cited by 551 · see citing works

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

Fox, N. C., Black, R. S., Gilman, S., Rossor, M. N., Griffith, S. G., Jenkins, L., & Koller, M. (2005) · Neurology · doi:10.1212/01.wnl.0000159743.08996.99 · Cited by 550 · see citing works

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

Turski, L., Bressler, K., Rettig, K.-J., Löschmann, P. A., & Wachtel, H. (1991) · Nature · doi:10.1038/349414a0 · Cited by 546 · see citing works

The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

Golts, N., Petrucelli, L., Hardy, J., Lee, J. M., Farer, M., & Wolozin, B. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06048.2000 · Cited by 544 · see citing works

α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

Bianco, C. L., Ridet, J.-L., Schneider, B. L., Déglon, N., & Aebischer, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152339799 · Cited by 533 · see citing works

Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: Benefit of a high-energy diet in a transgenic mouse model

Dupuis, L., Oudart, H., René, F., de Aguilar, J. G., & Loeffler, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402026101 · Cited by 532 · see citing works

Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons

Mattson, M. P., Rychlik, B., Chu, C., & Christakost, S. (1991) · Neuron · doi:10.1016/0896-6273(91)90120-o · Cited by 524 · see citing works

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517 · see citing works

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

Grimm, C., Wenzel, A., Groszer, M., Mayser, H., Seeliger, M. W., Samardzija, M., Bauer, C., Gassmann, M., & Remé, C. E. (2002) · Nature Medicine · doi:10.1038/nm723 · Cited by 517 · see citing works

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

Mattson, M. P., Barger, S. W., Cheng, B., Lieberburg, I. M., Smith‐Swintosky, V. L., & Rydel, R. E. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90009-b · Cited by 516 · see citing works

E PIDEMIOLOGY OF N EURODEGENERATION

Mayeux, R. P. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.043002.094919 · Cited by 511 · see citing works

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Parker, J. A., Arango-Lievano, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., & Néri, C. (2005) · Nature Genetics · doi:10.1038/ng1534 · Cited by 509 · see citing works

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Guo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Nature Medicine · doi:10.1038/4789 · Cited by 489 · see citing works

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04212.1997 · Cited by 487 · see citing works

Vesicle Permeabilization by Protofibrillar α-Synuclein Is Sensitive to Parkinson's Disease-Linked Mutations and Occurs by a Pore-like Mechanism

Volles, M. J., & Lansbury, P. T. (2002) · Biochemistry · doi:10.1021/bi0121353 · Cited by 485 · see citing works

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

Werth, J. L., & Thayer, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00348.1994 · Cited by 479 · see citing works

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:2:65 · Cited by 475 · see citing works

Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

Wang, S., Wilkes, M. C., Leof, E. B., & Hirschberg, R. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-2370com · Cited by 464 · see citing works

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

Cheng, B., & Mattson, M. P. (1991) · Neuron · doi:10.1016/0896-6273(91)90347-3 · Cited by 460 · see citing works

Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

Lee, H.-J., Choi, C., & Lee, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107045200 · Cited by 452 · see citing works

Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K

Yamada, T., McGeer, P. L., Baimbridge, K. G., & McGeer, E. G. (1990) · Brain Research · doi:10.1016/0006-8993(90)91236-a · Cited by 448 · see citing works

The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis

Yu, Z., Luo, H., Fu, W., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.7002 · Cited by 438 · see citing works

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428 · see citing works

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

Lovell, M. A., Ehmann, W. D., Mattson, M. P., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00108-5 · Cited by 413 · see citing works

Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns

Hof, P. R., Glezer, I. I., Condé, F., Flagg, R. A., Rubin, M. B., Nimchinsky, E. A., & Weisenhorn, D. M. V. (1999) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00065-9 · Cited by 411 · see citing works

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

Mattson, M., Murrain, M., Guthrie, P., & Kater, S. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03728.1989 · Cited by 409 · see citing works

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

Murphy, A. N., Bredesen, D. E., Cortopassi, G. A., Wang, E., & Fiskum, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9893 · Cited by 403 · see citing works

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

Cheng, B., & Mattson, M. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91857-0 · Cited by 394 · see citing works

Caloric restriction and intermittent fasting: Two potential diets for successful brain aging

Martin, B., Mattson, M. P., & Maudsley, S. R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.002 · Cited by 394 · see citing works

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

Pedersen, W. A., Fu, W., Keller, J. N., Markesbery, W. R., Appel, S. H., Smith, R. G., Kasarskis, E. J., & Mattson, M. P. (1998) · Annals of Neurology · doi:10.1002/ana.410440518 · Cited by 391 · see citing works

p53 in neuronal apoptosis

Culmsee, C., & Mattson, M. P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.149 · Cited by 388 · see citing works

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

Maswood, N., Young, J., Tilmont, E. M., Zhang, Z., Gash, D. M., Gerhardt, G. A., Grondin, R., Roth, G. S., Mattison, J. A., Lane, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405831102 · Cited by 383 · see citing works

The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

Alexianu, M. E., Ho, B., Mohamed, A. H., Bella, V. L., Smith, R. G., & Appel, S. H. (1994) · Annals of Neurology · doi:10.1002/ana.410360608 · Cited by 374 · see citing works

From form to function: calcium compartmentalization in dendritic spines

Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367 · see citing works

Disturbed Ca 2+ signaling and apoptosis of medium spiny neurons in Huntington's disease

Tang, T.-S., Slow, E., Lupu, V. D., Stavrovskaya, I. G., Sugimori, M., Llinás, R., Kristal, B. S., Hayden, M. R., & Борисович, Б. И. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409402102 · Cited by 360 · see citing works

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

Keller, J. N., Mark, R. J., Bruce‐Keller, A. J., Blanc, E. M., Rothstein, J. D., Uchida, K., Waeg, G., & Mattson, M. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00065-1 · Cited by 358 · see citing works

Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses

Mattson, M. P., & Cheng, A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.001 · Cited by 356 · see citing works

Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis

Kruman, I. I., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720529.x · Cited by 355 · see citing works

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

Mattson, M. P. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01188-0 · Cited by 344 · see citing works

Mechanisms of stroke protection by physical activity

Endres, M., Gertz, K. R., Lindauer, U., Katchanov, J., Schultze, J., Schröck, H., Nickenig, G., Kuschinsky, W., Dirnagl, U., & Laufs, U. (2003) · Annals of Neurology · doi:10.1002/ana.10722 · Cited by 330 · see citing works

Mitochondrial mechanisms of neural cell apoptosis

Polster, B. M., & Fiskum, G. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02572.x · Cited by 329 · see citing works

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329 · see citing works

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

Stein-Behrens, B., Mattson, M., Chang, I., Yeh, M., & Sapolsky, R. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05373.1994 · Cited by 327 · see citing works

Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

Stutzmann, G. E., Smith, I. F., Caccamo, A., Oddo, S., LaFerla, F. M., & Parker, I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0739-06.2006 · Cited by 327 · see citing works

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

Cutler, R. G., Pedersen, W. A., Camandola, S., Rothstein, J. D., & Mattson, M. P. (2002) · Annals of Neurology · doi:10.1002/ana.10312 · Cited by 325 · see citing works

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K. P., Dolios, G., Wang, R., Hof, P. R., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3182fje · Cited by 317 · see citing works

Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways

Altar, C. A., Laeng, P., Jurata, L. W., Brockman, J. A., Lemire, A. L., Bullard, J., Bukhman, Y. V., Young, T. A., Charles, V., & Palfreyman, M. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5377-03.2004 · Cited by 317 · see citing works

Ischemic Tolerance

Kirino, T. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000040942.89393.88 · Cited by 302 · see citing works

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons.

Mattson, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90447-n · Cited by 292 · see citing works

Free radicals and brain aging

Poon, H. F., Calabrese, V., Scapagnini, G., & Butterfield, D. A. (2004) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2004.02.005 · Cited by 292 · see citing works

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

Beal, M. F. (1998) · Annals of Neurology · doi:10.1002/ana.410440716 · Cited by 283 · see citing works

The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity

Weiss, J. H., Hartley, D. M., Koh, J., & Choi, D. W. (1990) · Science · doi:10.1126/science.2157282 · Cited by 273 · see citing works

The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

Furukawa, K., Fu, W., Li, Y., Witke, W., Kwiatkowski, D. J., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08178.1997 · Cited by 269 · see citing works

ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis

Kruman, I. I., Pedersen, W. A., Springer, J. E., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7190 · Cited by 268 · see citing works

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

Mattson, M. P., Zhang, Y., & Bose, S. C. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1066 · Cited by 265 · see citing works

Mitochondria in cell death: novel targets for neuroprotection and cardioprotection

Mattson, M. P., & Kroemer, G. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00046-7 · Cited by 264 · see citing works

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263 · see citing works

Deranged neuronal calcium signaling and Huntington disease

Борисович, Б. И., & Hayden, M. R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.035 · Cited by 256 · see citing works

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

Cheng, B., & Mattson, M. P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01558.1992 · Cited by 254 · see citing works

Presence of 4‐hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

Smith, R. G., Henry, Y. K., Mattson, M. P., & Appel, S. H. (1998) · Annals of Neurology · doi:10.1002/ana.410440419 · Cited by 254 · see citing works

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

Furukawa, K., & Mattson, M. P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051876.x · Cited by 254 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Greenamyre, J. T., MacKenzie, G. M., Peng, T., & Stephans, S. E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660085 · Cited by 248 · see citing works

GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway.

Anitha, M., Gondha, C., Sutliff, R., Parsadanian, A., Mwangi, S., Sitaraman, S., & Srinivasan, S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26295 · Cited by 243 · see citing works

Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

Jankowsky, J. L., Xu, G. M., Fromholt, D., Gonzales, V., & Borchelt, D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1220 · Cited by 238 · see citing works

Dantrolene Prevents Glutamate Cytotoxicity and Ca2+ Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

Frandsen, A., & Schousboe, A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02031.x · Cited by 237 · see citing works

Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition

Arendash, G. W., Garcia, M. F., Costa, D. A., Cracchiolo, J. R., Wefes, I., & Potter, H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000137183.68847.4e · Cited by 237 · see citing works

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

Soriano, F. X., Papadia, S., Hofmann, F., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0455-06.2006 · Cited by 236 · see citing works

Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits

Wang, Q., Sun, A. Y., Simonyi, Á., Jensen, M. D., Shelat, P. B., Rottinghaus, G. E., MacDonald, R. S., Miller, D. K., Lubahn, D. E., Weisman, G. A., et al. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20610 · Cited by 233 · see citing works

Molecular mechanism of neurodegeneration induced by Alzheimer’s β-amyloid protein: channel formation and disruption of calcium homeostasis

Kawahara, M., & Kuroda, Y. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00370-1 · Cited by 221 · see citing works

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

Tymianski, M., Wallace, M. C., Spigelman, I., Uno, M., Carlen, P. L., Tator, C. H., & Charlton, M. P. (1993) · Neuron · doi:10.1016/0896-6273(93)90180-y · Cited by 219 · see citing works

Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage

Gao, X., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403886101 · Cited by 215 · see citing works

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

Huynh, D. P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg269 · Cited by 215 · see citing works

Oxidative Stress and Neuronal Death/Survival Signaling in Cerebral Ischemia

Saito, A., Maier, C. M., Narasimhan, P., Nishi, T., Song, Y. S., Yu, F., Liu, J., Lee, Y., Nito, C., Kamada, H., et al. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:105 · Cited by 213 · see citing works

The calpains in aging and aging-related diseases

Nixon, R. A. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00029-1 · Cited by 211 · see citing works

Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆

Smith, A. D., & Zigmond, M. J. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.08.017 · Cited by 209 · see citing works

Reactive Oxygen and Nitrogen Species: Weapons of Neuronal Destruction in Models of Parkinson's Disease

Przedborski, S., & Ischiropoulos, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.685 · Cited by 202 · see citing works

Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury

Springer, J. E., Azbill, R. D., Nottingham, S. A., & Kennedy, S. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07246.2000 · Cited by 201 · see citing works

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury

Giffard, R. G., Xu, L., Zhao, H., Carrico, W., Ouyang, Y., Qiao, Y., Sapolsky, R. M., Steinberg, G. K., Hu, B. R., & Yenari, M. A. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01034 · Cited by 199 · see citing works

Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor

Barger, S. W., & Mattson, M. P. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00036-8 · Cited by 195 · see citing works

Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress

Sawada, H., Ibi, M., Kihara, T., Urushitani, M., Akaike, A., Kimura, J., & Shimohama, S. (1998) · Annals of Neurology · doi:10.1002/ana.410440117 · Cited by 193 · see citing works

Excitotoxicity and Amyotrophic Lateral Sclerosis

van Cutsem, P., Dewil, M., Robberecht, W., & Bosch, L. V. D. (2005) · Neurodegenerative Diseases · doi:10.1159/000089620 · Cited by 192 · see citing works

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

Duan, W., Guo, Z., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00071.x · Cited by 187 · see citing works

Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS

von Lewinski, F., & Keller, B. U. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.001 · Cited by 186 · see citing works

Neuroprotection by Hypoxic Preconditioning Involves Oxidative Stress-Mediated Expression of Hypoxia-Inducible Factor and Erythropoietin

Liu, J., Narasimhan, P., Yu, F., & Chan, P. H. (2005) · Stroke · doi:10.1161/01.str.0000166180.91042.02 · Cited by 183 · see citing works

Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain

Paschen, W. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00139-8 · Cited by 180 · see citing works

Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

Hong, S., Goto, Y., Lanzino, G. S., Soleau, S. W., Kassell, N. F., & Lee, K. S. (1994) · Stroke · doi:10.1161/01.str.25.3.663 · Cited by 180 · see citing works

Mitochondrial UCP4 Mediates an Adaptive Shift in Energy Metabolism and Increases the Resistance of Neurons to Metabolic and Oxidative Stress

Liu, D., Chan, S. L., de Souza-Pinto, N. C., Slevin, J. R., Wersto, R. P., Zhan, M., Mustafa, K., de Cabo, R., & Mattson, M. P. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:3:389 · Cited by 180 · see citing works

Stroke--incidence, mortality, morbidity and risk.

Ingall, T. J. (2004) · PubMed · Cited by 178 · see citing works

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

Blanc, E. M., Toborek, M. J., Mark, R. J., Hennig, B., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68051870.x · Cited by 174 · see citing works

Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal IschemiaIn Vivoand to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

Mattson, M. P., Zhu, H., Yu, J., & Kindy, M. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01358.2000 · Cited by 172 · see citing works

Huntingtin Associates with Acidic Phospholipids at the Plasma Membrane

Kegel, K. B., Sapp, E., Yoder, J. L., Cuiffo, B., Sobin, L. B., Kim, Y. J., Qin, Z., Hayden, M. R., D, N. A. M., Scott, D. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503672200 · Cited by 172 · see citing works

Parvalbumin overexpression alters immune‐mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis

Beers, D. R., Ho, B., Siklós, L., Alexianu, M. E., Mosier, D. R., Mohamed, A. H., Otsuka, Y., Kozovska, M. E., McAlhany, R. E., Smith, R. G., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00582.x · Cited by 166 · see citing works

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

Zhu, H., Guo, Q., & Mattson, M. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01827-2 · Cited by 166 · see citing works

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

Rg, M., Jd, M., Lyon, M., & Moore, D. (2003) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820310002601 · Cited by 159 · see citing works

Immunotherapy for Alzheimer's disease

Gélinas, D. S., Silva, K. D., Fenili, D., George‐Hyslop, P. S., & McLaurin, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404866101 · Cited by 156 · see citing works

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.

Tateno, M., Sadakata, H., Tanaka, M., Itohara, S., Shin, R.-M., Miura, M., Masuda, M., Aosaki, T., Urushitani, M., Misawa, H., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh246 · Cited by 150 · see citing works

Experimental Stroke in the Female Diabetic, db/db , Mouse

Vannucci, S. J., Willing, L. B., Goto, S., Alkayed, N. J., Brucklacher, R. M., Wood, T. L., Towfighi, J., Hurn, P. D., & Simpson, I. A. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00007 · Cited by 149 · see citing works

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity

Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07100.1999 · Cited by 148 · see citing works

The plasma membrane redox system in aging

Hyun, D., Hernandez, J. O., Mattson, M. P., & de Cabo, R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.005 · Cited by 146 · see citing works

Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study

Kasarskis, E. J., Tandon, L., Lovell, M. A., & Ehmann, W. D. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00037-3 · Cited by 145 · see citing works

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

Leist, M., Fava, E., Montecucco, C., & Nicotera, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01503.x · Cited by 143 · see citing works

Caspase-Dependent and -Independent Neuronal Death: Two Distinct Pathways to Neuronal Injury

Stefanis, L. (2005) · The Neuroscientist · doi:10.1177/1073858404271087 · Cited by 142 · see citing works

Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

Mark, R. J., Keller, J. N., Kruman, I., & Mattson, M. P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00196-0 · Cited by 141 · see citing works

A role for Na + ‐dependent Ca 2+ extrusion in protection against neuronal excitotoxicity

Mattson, M. P., Guthrie, P. B., & Kater, S. B. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.13.2572500 · Cited by 136 · see citing works

Regulation of Calcium/Calmodulin-dependent Protein Kinase II Docking toN-Methyl-d-aspartate Receptors by Calcium/Calmodulin and α-Actinin

Leonard, A. S., Bayer, K. U., Merrill, M. A., Lim, I. A., Shea, M. A., Schulman, H., & Hell, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205164200 · Cited by 136 · see citing works

Hormesis/preconditioning mechanisms, the nervous system and aging

Arumugam, T. V., Gleichmann, M., Tang, S., & Mattson, M. P. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.003 · Cited by 131 · see citing works

A Mechanism for the Neuroprotective Effect of Apolipoprotein E

Pedersen, W. A., Chan, S. L., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741426.x · Cited by 130 · see citing works

Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke

Collins, R. C., Dobkin, B. H., & Choi, D. W. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-12-992 · Cited by 123 · see citing works

Short-term effects of the calcium channel blocker nimodipine (Bay-e-9736) in the management of primary degenerative dementia

Tollefson, G. D. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90050-c · Cited by 121 · see citing works

Diabetic neuropathies in brain are induced by deficiency of BDNF

Nitta, A., Murai, R., Suzuki, N., Ito, H., Nomoto, H., Katoh, G., Furukawa, Y., & Furukawa, S. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(02)00220-9 · Cited by 120 · see citing works

Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress

Chan, S. L., Fu, W., Zhang, P., Cheng, A., Lee, J., Kokame, K., & Mattson, M. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404272200 · Cited by 118 · see citing works

Plasma membrane ion permeability induced by mutant α‐synuclein contributes to the degeneration of neural cells

Furukawa, K., Matsuzaki‐Kobayashi, M., Hasegawa, T., Kikuchi, A., Sugeno, N., Itoyama, Y., Wang, Y., Yao, P. J., Bushlin, I., & Takeda, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03803.x · Cited by 113 · see citing works

Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells

Nicholls, D. G., Vesce, S., Kirk, L., & Chalmers, S. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00144-1 · Cited by 108 · see citing works

Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor

Gobbo, O. L., & O’Mara, S. M. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.09.021 · Cited by 104 · see citing works

No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice

Pedersen, W. A., & Mattson, M. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01471-7 · Cited by 104 · see citing works

The calcium channel

Hagiwara, S., & Byerly, L. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90084-x · Cited by 103 · see citing works

Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?

Prigent, A., Agid, Y., & Hirsch, É. C. (1994) · Brain Research · doi:10.1016/0006-8993(94)90511-8 · Cited by 102 · see citing works

Age‐Dependent Changes in the Calcium Sensitivity of Striatal Mitochondria in Mouse Models of Huntington's Disease

Brustovetsky, N., LaFrance, R., Purl, K. J., Brustovetsky, T., Keene, C. D., Low, W. C., & Dubinsky, J. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03036.x · Cited by 101 · see citing works

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca2+ Responses to AMPA and NMDA in Hippocampal Neurons

Cheng, B., Furukawa, K., O'Keefe, J. A., Goodman, Y., Kihiko, M., Fabian, T., & Mattson, M. P. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65062525.x · Cited by 101 · see citing works

Prostate Apoptosis Response‐4 Production in Synaptic Compartments Following Apoptotic and Excitotoxic Insults

Duan, W., Rangnekar, V. M., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722312.x · Cited by 97 · see citing works

Determinants of postsynaptic Ca2+ signaling in Purkinje neurons

Hartmann, J., & Konnerth, A. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.014 · Cited by 96 · see citing works

Apolipoprotein E and Cholesterol Affect Neuronal Calcium Signaling: The Possible Relationship to β-Amyloid Neurotoxicity

Hartmann, H., Eckert, A., & Müller, W. E. G. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1576 · Cited by 95 · see citing works

Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length

Moulder, K. L., Onodera, O., Burke, J. R., Strittmatter, W. J., & Johnson, E. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00705.1999 · Cited by 94 · see citing works

Presynaptic Ca2+ dynamics, Ca2+ buffers and synaptic efficacy

Burnashev, N., & Rozov, A. V. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.003 · Cited by 93 · see citing works

Endoplasmic reticulum calcium release is modulated by actin polymerization

Wang, Y., Mattson, M. P., & Furukawa, K. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01059.x · Cited by 90 · see citing works

Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage

Pérez‐Navarro, E., Arenas, E., Reiriz, J., Calvo, N., & Alberch, J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00336-3 · Cited by 90 · see citing works

Efficacy and Safety of Memantine in Moderate-to-Severe Alzheimer Disease: The Evidence to Date

Bullock, R. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201847.29836.a5 · Cited by 89 · see citing works

The darker side of Ca signaling by neuronal Ca-sensor proteins: from Alzheimer's disease to cancer

Braunewell, K. H. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.008 · Cited by 87 · see citing works

Mitochondrial enzyme activities as biochemical markers of aging

Navarro, A. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.007 · Cited by 82 · see citing works

Huntington?s disease: pathomechanism and therapeutic perspectives

G�rdi�n, G., & V�csei, L. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0201-4 · Cited by 76 · see citing works

Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation

Furukawa, K., Wang, Y., Yao, P. J., Fu, W., Mattson, M. P., Itoyama, Y., Onodera, H., D’Souza, I., Poorkaj, P., Bird, T. D., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02020.x · Cited by 70 · see citing works

Effects of cerebral ischemia in mice deficient in Persephin

Tomac, A. C., Agulnick, A. D., Haughey, N. J., Chang, C.-F., Zhang, Y., Bäckman, C. M., Morales, M., Mattson, M. P., Wang, Y., Westphal, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152535899 · Cited by 69 · see citing works

Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia

Nellg�rd, B., & Wieloch, T. W. (1992) · Experimental Brain Research · doi:10.1007/bf00227969 · Cited by 66 · see citing works

In CA1 Pyramidal Neurons of the Hippocampus Protein Kinase C Regulates Calcium-Dependent Inactivation of NMDA Receptors

Lu, W.-Y., Jackson, M. F., Bai, D., Orser, B. A., & MacDonald, J. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04452.2000 · Cited by 66 · see citing works

Mitochondrial uncoupling as a potential therapeutic target in acute central nervous system injury

Maragos, W. F., & Korde, A. S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02736.x · Cited by 63 · see citing works

Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion

Ramsden, M., Berchtold, N. C., Kesslak, J. P., Cotman, C. W., & Pike, C. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02365-5 · Cited by 62 · see citing works

Evidence that Brain-Derived Neurotrophic Factor from Presynaptic Nerve Terminals Regulates the Phenotype of Calbindin-Containing Neurons in the Lateral Septum

Fawcett, J. P., Alonso‐Vanegas, M., Morris, S. J., Miller, F. D., Sadikot, A. F., & Murphy, R. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00274.2000 · Cited by 54 · see citing works

Expression of neurotrophins and their receptors in sciatic nerve of experimentally diabetic rats

Rodríguez‐Peña, A., Botana, M., González, M., et al. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12067-e · Cited by 52 · see citing works

Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes

Winkler, M. K., & Benveniste, E. N. (1998) · Glia · doi:10.1002/(sici)1098-1136(199802)22:2 · Cited by 50 · see citing works

Noninvasively Induced Degeneration of Neocortical Pyramidal Neurons in Vivo: Selective Targeting by Laser Activation of Retrogradely Transported Photolytic Chromophore

Madison, R. D., & Macklis, J. D. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1082 · Cited by 49 · see citing works

ALS-Linked Cu/Zn-SOD Mutation Impairs Cerebral Synaptic Glucose and Glutamate Transport and Exacerbates Ischemic Brain Injury

Guo, Z., Kindy, M. S., Kruman, I. I., et al. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00004 · Cited by 45 · see citing works

Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease

Chan, S. L., Furukawa, K., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:167 · Cited by 45 · see citing works

The role of Bax in glutamate‐induced nerve cell death

Dargusch, R., Piasecki, D. P., Tan, S., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00035.x · Cited by 43 · see citing works

Elemental Analysis of Neurofibrillary Tangles in Alzheimer's Disease Using Proton‐Induced X‐ray Analysis

Murray, F. E. S., Landsberg, J. P., Williams, R. J. P., Esiri, M. M., & Watt, F. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514306.ch12 · Cited by 42 · see citing works

Effects of Streptozotocin-Induced Hyperglycemia on Brain Damage Following Transient Ischemia

Li, C., Li, P., He, Q., et al. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0189 · Cited by 40 · see citing works

Protein Kinase C Modulates Calcium Channels in Isolated Presynaptic Nerve Terminals of Rat Hippocampus

Bartschat, D. K., & Rhodes, T. E. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052064.x · Cited by 39 · see citing works

Peroxynitrite affects Ca2+ influx through voltage‐dependent calcium channels

Ohkuma, S., Katsura, M., Higo, A., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00045.x · Cited by 39 · see citing works

Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain

Lee, H., Wang, C., Hu, Z., et al. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00774.x · Cited by 37 · see citing works

Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant

Firdaus, W. J. J., Wyttenbach, A., Diaz‐Latoud, C., Currie, R. W., & Arrigo, A. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05318.x · Cited by 35 · see citing works

Isolation and culture of bovine endothelial cells of endoneurial origin

Kanda, T., Iwasaki, T., Yamawaki, M., & Ikeda, K. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 35 · see citing works

Identification of PSF, the polypyrimidine tract-binding protein-associated splicing factor, as a developmentally regulated neuronal protein

Chanas-Sacré, G., Mazy‐Servais, C., Wattiez, R., Pirard, S., Rogister, B., Patton, J. G., Belachew, S. M., Malgrange, B., Moonen, G., & Leprince, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990701)57:1 · Cited by 33 · see citing works

Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production

Drew, B., & Leeuwenburgh, C. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01371.x · Cited by 32 · see citing works

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity.

Liang, Z.-Q., Wang, X., Wang, Y.-M., Chuang, D. M., DiFiglia, M., Chase, T., & Qin, Z.-H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.011 · Cited by 31 · see citing works

Suppression of Calcium Release from Inositol 1,4,5-Trisphosphate-sensitive Stores Mediates the Anti-apoptotic Function of Nuclear Factor-κB

Camandola, S., Cutler, R. G., Gary, D. S., Milhavet, O., & Mattson, M. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410923200 · Cited by 30 · see citing works

Perturbed Signal Transduction in Neurodegenerative Disorders Involving Aberrant Protein Aggregation

Mattson, M. P., & Sherman, M. Y. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:109 · Cited by 28 · see citing works

Preconditioning-induced protection against cyanide-induced neurotoxicity is mediated by preserving mitochondrial function

Jensen, M. S., Ahlemeyer, B., Ravati, A., et al. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00096-1 · Cited by 21 · see citing works

Bcl-2 and Ca2+-mediated mitochondrial dysfunction in neural cell death

Murphy, A. N., & Fiskum, G. M. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660033 · Cited by 21 · see citing works

Good and Bad Amyloid Antibodies

Mattson, M. P., & Chan, S. L. (2003) · Science · doi:10.1126/science.301.5641.1847 · Cited by 17 · see citing works

Mechanisms of disease pathogenesis in amyotrophic lateral sclerosis. A central role for calcium.

Simpson, E. P., Mosier, D., & Appel, S. H. (2002) · PubMed · Cited by 12 · see citing works

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Untitled work

(1999) · doi:10.1002/(sici)1097-4547(19990915)57:6

Hallmarks of neurodegenerative diseases

Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789 · see citing works

Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138 · see citing works

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.018 · Cited by 697 · see citing works

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D. S., Tabrizi, S. J., Wood, N. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.013 · Cited by 682 · see citing works

Aβ Oligomers Cause Localized Ca ²⁺ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

Zempel, H., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2357-10.2010 · Cited by 686 · see citing works

Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614 · see citing works

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

Li, Y., Perry, T., Kindy, M. S., Harvey, B. K., Tweedie, D., Holloway, H. W., Powers, K., Shen, H., Egan, J. M., Sambamurti, K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806720106 · Cited by 589 · see citing works

Molecular Mechanisms and Clinical Implications of Reversible Protein <i>S</i> -Glutathionylation

Mieyal, J. J., Gallogly, M. M., Qanungo, S., Sabens, E. A., & Shelton, M. D. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2008.2089 · Cited by 523 · see citing works

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

Verma, M., Lizama, B. N., & Chu, C. T. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-021-00278-7 · Cited by 451 · see citing works

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

Arnsten, A. F. T., Datta, D., Del Tredici, K., & Braak, H. (2021) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12192 · Cited by 361 · see citing works

The path from mitochondrial <scp>ROS</scp> to aging runs through the mitochondrial permeability transition pore

Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Soluble forms of tau are toxic in Alzheimer's disease

Kopeikina, K., Hyman, B., & Spires-Jones, T. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0032-y · Cited by 232 · see citing works

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230 · see citing works

Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

Govindpani, K., Calvo-Flores Guzmán, B., Vinnakota, C., Waldvogel, H., Faull, R., & Kwakowsky, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081813 · Cited by 208 · see citing works

Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

Paula‐Lima, A. C., Brito‐Moreira, J., & Ferreira, S. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12304 · Cited by 170 · see citing works

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173 · see citing works

Interaction of Mitochondrial Calcium and ROS in Neurodegeneration

Baev, A. Y., Vinokurov, A. Y., Novikova, I. N., Dremin, V. V., Potapova, E. V., & Abramov, A. Y. (2022) · Cells · doi:10.3390/cells11040706 · Cited by 162 · see citing works

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322360111 · Cited by 139 · see citing works

The Mitochondrial Permeability Transition Pore Regulates Nitric Oxide-Mediated Apoptosis of Neurons Induced by Target Deprivation

Martin, L. J., Adams, N. A., Pan, Y., Price, A., & Wong, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2225-10.2011 · Cited by 96 · see citing works

Endonuclease G mediates α‐synuclein cytotoxicity during Parkinson's disease

Büttner, S., Habernig, L., Broeskamp, F., Ruli, D., Vögtle, F. N., Vlachos, M., Macchi, F., Küttner, V., Carmona‐Gutierrez, D., Eisenberg, T., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.228 · Cited by 87 · see citing works

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

Arnsten, A. F. T., Datta, D., Leslie, S., Yang, S.-T., Wang, M., & Nairn, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903671116 · Cited by 74 · see citing works

The ER and ageing II: Calcium homeostasis

Puzianowska-Kuznicka, M., & Kuznicki, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.002 · Cited by 73 · see citing works

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease

Golde, T. E. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-8 · Cited by 71 · see citing works

Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13065 · Cited by 50 · see citing works

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

Chiarini, A., Armato, U., Liu, D., & Dal Prà, I. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00134 · Cited by 51 · see citing works

Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology

Uranga, R. M., & Salvador, G. A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2850341 · Cited by 48 · see citing works

“Aducanumab” making a comeback in Alzheimer’s disease: An old wine in a new bottle

Behl, T., Kaur, I., Sehgal, A., Singh, S., Sharma, N., Makeen, H. A., Albratty, M., Alhazmi, H. A., Felemban, S. G., Alsubayiel, A. M., et al. (2022) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2022.112746 · Cited by 50 · see citing works

Inhaled essential oil from<i>Chamaecyparis obtuse</i>ameliorates the impairments of cognitive function induced by injection of β-amyloid in rats

Bae, D., Seol, H., Yoon, H.-G., Na, J.-R., Oh, K., Choi, C. Y., Lee, D.-W., Jun, W., Youl Lee, K., Lee, J., et al. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2011.642886 · Cited by 35 · see citing works

p600/UBR4 in the central nervous system

Parsons, K., Nakatani, Y., & Nguyen, M. D. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1788-8 · Cited by 35 · see citing works

γ‐Secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines

Ng, A. N., & Toresson, H. (2008) · The FASEB Journal · doi:10.1096/fj.07-103903 · Cited by 14 · see citing works

The Anemonia Sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ1-42 Oligomers by Restoring [Ca2+]i Transients and ER Ca2+ Signaling

Piccialli, I., Tedeschi, V., Boscia, F., Ciccone, R., Casamassa, A., de Rosa, V., Grieco, P., Secondo, A., & Pannaccione, A. (2020) · Toxins · doi:10.3390/toxins13010020 · Cited by 14 · see citing works

MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1

Yoo, M., Choi, D. C., Murphy, A., Ahsan, A. M., & Junn, E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104709 · Cited by 6 · see citing works

Tissue Transglutaminase Selectively Modifies Proteins Associated with Truncated Mutant Huntingtin in Intact Cells

Chun, W., Lesort, M. J., Tucholski, J., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0390 · Cited by 35 · see citing works

The huntingtin protein in Huntington disease

Schut, M. H. (2017) · Data Archiving and Networked Services (DANS)

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Kuhn, A., Goldstein, D. R., Hodges, A., Strand, A. D., Sengstag, T., Kooperberg, C. L., Bečanović, K., Pouladi, M. A., Sathasivam, K., Cha, J.-H. J., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm133 · Cited by 327 · see citing works

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

Kordasiewicz, H. B., Stanek, L. M., Wancewicz, E. V., Mazur, C., McAlonis, M. M., Pytel, K. A., Artates, J. W., Weiss, A., Cheng, S. H., Shihabuddin, L. S., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.009 · Cited by 770 · see citing works

Huntingtin: Here, There, Everywhere!

Sousa, C. M., & Humbert, S. (2013) · Journal of Huntington s Disease · doi:10.3233/jhd-130082 · Cited by 74 · see citing works