The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Lack of an effect of vitamin E on lifespan of mice
Abstract
It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing to the action of oxidising free radicals. This possibility would predict that administration of anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on lifespan was observed and the median lifespans in the three groups were 804, 830 and 801 days, respectively. The design of the study also enabled an effect of parental age on lifespan of female progeny to be sought, but no effect was detected.
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“One study examining life-long supplementation of vitamin E in mice showed no overall improvement in life span [50].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [50]
Citations
Cites
Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461
Detection of a specific mitochondrial DNA deletion in tissues of older humans
Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 788
A Transmissible, Cumulative, and Reversible Factor in Aging
Lansing, A. I. (1947) · Journal of Gerontology · doi:10.1093/geronj/2.3.228 · Cited by 277
Hattori, K., Tanaka, M., Sugiyama, S., Obayashi, T., Ito, T., Satake, T., Hanaki, Y., Asai, J., Nagano, M., & Ozawa, T. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90020-i · Cited by 264
Tappel, A. L., Fletcher, B. L., & Deamer, D. W. (1973) · Journal of Gerontology · doi:10.1093/geronj/28.4.415 · Cited by 224
Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice
Liu, X., Ondek, B., & Williams, D. S. (1998) · Nature Genetics · doi:10.1038/470 · Cited by 168
Mitochondrial gene mutation: the ageing process and degenerative diseases.
Linnane, A. W., Baumer, A., Maxwell, R. J., Preston, H. S., Zhang, C. F., & Marzuki, S. (1990) · PubMed · Cited by 165
Mutation frequency in human lymphocytes increases with age
Trainor, K. J., Wigmore, D. J., CHRYSOSTOMOU, A., Dempsey, J. L., Seshadri, R., & Morley, A. A. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90084-8 · Cited by 137
Zhang, C., Linnane, A. W., & Nagley, P. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2158 · Cited by 134
Heidrick, M. L., Hendricks, L. C., & Cook, D. E. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90057-5 · Cited by 102
Research works printed but not linked: 3
- Jensen RH,Bigbee WL andLanglois RG (1988) In vivo somatic mutations in the glycophorin A locus of human erythroid cells In: Moore MM,DeMarini DM andTindall KR (eds) Banbury Report 28: Mammalian Cell Mutagenesis, pp 149–159. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
- Kohn RR (1971) Effect of anti-oxidants in lifespan of C57H mice. J Gerontol 28: 415–424
- Miquel J,Binnard R andHoward WH (1973) Effect of dl-α-tocopherol on the life span of Drosophila melanogaster. Gerontologist 13: 37
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Mouse Models in Aging Research
FLURKEY, K., MCURRER, J., & HARRISON, D. (2007) · The Mouse in Biomedical Research · doi:10.1016/b978-012369454-6/50074-1 · Cited by 723
Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813
Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.002 · Cited by 565
Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628157 · Cited by 478
Oxidative stress and aging: beyond correlation
Golden, T. R., Hinerfeld, D. A., & Melov, S. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00015.x · Cited by 343
Metadata
- Authors
- Morley, A. A., & Trainor, K. J.
- Affiliations
- Flinders University (AU)
- Corresponding author
- Morley, Alexander A.
- ORCID
- Morley, Alexander A.
- Venue
- Biogerontology
- Published
- 2001-06
- Volume
- 2
- Issue
- 2
- Pages
- 109-112
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W149809163
- Cited by
- 64
- References
- 29
- Citations by year
- 2023: 3 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin E, lifespan, aging, antioxidants, free radicals, oxidative DNA damage, dietary supplementation, parental age, mice
- MeSH terms
- Animals, Antioxidants, Female, Longevity, Male, Mice, Inbred BALB C, Vitamin E, Mice
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