Cited by 64Genetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

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Lack of an effect of vitamin E on lifespan of mice

Morley, Alexander A., Trainor, Kevin J.·2001·Biogerontology

DOI 10.1023/a:1011589218219

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Abstract

It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing to the action of oxidising free radicals. This possibility would predict that administration of anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on lifespan was observed and the median lifespans in the three groups were 804, 830 and 801 days, respectively. The design of the study also enabled an effect of parental age on lifespan of female progeny to be sought, but no effect was detected.

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Authors: Morley, A. A., & Trainor, K. J.
Affiliations: Flinders University (AU)
Corresponding author: Morley, Alexander A.
ORCID: Morley, Alexander A.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2001-06
Volume: 2
Issue: 2
Pages: 109-112
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1023/a:1011589218219
OpenAlex: W149809163
Cited by: 64
References: 29
Citations by year: 2023: 3 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 1.08
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: vitamin E, lifespan, aging, antioxidants, free radicals, oxidative DNA damage, dietary supplementation, parental age, mice
MeSH terms: Animals, Antioxidants, Female, Longevity, Male, Mice, Inbred BALB C, Vitamin E, Mice

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Lack of an effect of vitamin E on lifespan of mice

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