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Causes of death in autism.
Abstract
The objective of this study was to determine which causes of death are more frequent in persons with autism, and by how much, compared with the general population. Subjects were 13,111 ambulatory Californians with autism, followed between 1983 and 1997. The units of study were person-years, each linked to the subject's age, sex, and cause of death (if any) for the specific year. Observed numbers of cause-specific deaths were compared with numbers expected according to general population mortality rates. Standardized mortality rates (SMRs) were computed for each mental retardation level. Elevated death rates were observed for several causes, including seizures and accidents such as suffocation and drowning; elevated mortality due to respiratory disease was observed among persons with severe mental retardation. Overall, excess mortality was especially marked for persons with severe mental retardation, but life expectancy is reduced even for persons who are fully ambulatory and who have only mild mental retardation.
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Thom, R. P., Palumbo, M. L., Keary, C. J., Hooker, J. M., McDougle, C. J., & Ravichandran, C. T. (2022) · Scientific Reports · doi:10.1038/s41598-022-13365-0 · Cited by 18
Metadata
- Authors
- Shavelle, R. M., Strauss, D. J., & Pickett, J.
- Corresponding author
- Pickett, Jane
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2001-12
- Volume
- 31
- Issue
- 6
- Pages
- 569-576
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1564218038
- Cited by
- 211
- References
- 22
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 17 · 2020: 7 · 2019: 15 · 2018: 5 · 2017: 3 · 2016: 23 · 2015: 8 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh031862-24)
- National Institute of Mental Health (R01 MH31862-21S1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, causes of death, mortality, standardized mortality ratio, intellectual disability, seizures, accidents, suffocation, drowning, respiratory diseases, life expectancy, ambulatory adults
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Female, Humans, Male, Intellectual Disability, Survival Rate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.