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Cited by 247Cholangiocarcinoma and Gallbladder Cancer StudiesLiver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy

Donato, Francesco, Gelatti, Umberto, Tagger, Alessandro, Favret, Maurizio, Ribero, Maria Lisa, Callea, Francesco, Martelli, Claudia, Savio, Antonella +2 more·2001·Cancer Causes & Control
DOI 10.1023/a:1013747228572
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Abstract

Objective Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995-2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake >80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6-58.9) for anti-HCV, 2.7 (0.4-18.4) for HBsAg, and 6.7 (1.3-33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions HCV and hepatolithiasis may be risk factors for ICC in Western countries.

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  • Major risk factors for cholangiocarcinoma vary by region and include liver flukes (e.g., in the northeast region of Thailand, where Opisthorchis viverrini is endemic) and metabolic conditions (including obesity, diabetes, and nonalcoholic fatty liver disease), alongside heavy alcohol consumption and HBV and HCV infections.

    “Major risk factors for cholangiocarcinoma also vary by region and include liver flukes (e.g., in the northeast region of Thailand, where Opisthorchis viverrini, is endemic) 121 and metabolic conditions (including obesity, diabetes, and nonalcoholic fatty liver disease), alongside heavy alcohol consumption and HBV and HCV infections.122-124”

    From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [124]

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Authors
Donato, F., Gelatti, U., Tagger, A., Favret, M., Ribero, M. L., Callea, F., Martelli, C., Savio, A., Trevisi, P., & Nardi, G.
Affiliations
  • University of Brescia (IT)
  • University of Milan (IT)
  • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
  • Ospedale Sant'Orsola di Brescia (IT)
Corresponding author
Donato, Francesco
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2001-12
Volume
12
Issue
10
Pages
959-964
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1013747228572
OpenAlex
W1502967669
Cited by
247
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 4 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 18 · 2012: 18
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords
intrahepatic cholangiocarcinoma, hepatitis C virus, hepatitis B virus, HBsAg seropositivity, anti-HCV seropositivity, alcohol consumption, hepatolithiasis, primary liver cancer, risk factors, liver cirrhosis, Brescia
MeSH terms
Aged, Aged, 80 and over, Alcohol Drinking, Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Female, Hepatitis B, Hepatitis C, Humans, Italy, Liver Cirrhosis, Liver Neoplasms, Male, Middle Aged, Risk Factors, Prevalence, Case-Control Studies, Cholangiocarcinoma, Lithiasis

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