Cited by 118Glycosylation and Glycoproteins ResearchAllergic Rhinitis and SensitizationFood Allergy and Anaphylaxis Research

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N- and O-linked oligosaccharides of allergenic glycoproteins

Fötisch, Kay, Vieths*, Stefan·2001·Glycoconjugate Journal

DOI 10.1023/a:1014860030380

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Abstract

Cross-linking of cell-bound IgE on mast cells or basophils by polyvalent antigens causes the release of histamine and other mediators of the allergic response which then lead to the development of allergic symptoms. In this event not only peptide epitopes, but also carbohydrates can act as cross-linking elements. Since peptide epitopes of allergens are subject of most published studies, this review is focused on glycosidic epitopes. The current knowledge of the structures and possible epitopes of oligosaccharides linked to allergenic glycoproteins is briefly reviewed, showing that complex plant N-glycans containing alpha1,3 fucose and beta1,2 xylose are most frequently involved in the structures of IgE epitopes. In own studies a prevalence of up to 29% anti-glycan IgE was determined among pollen-allergic patients. The clinical relevance of these carbohydrate specific IgE antibodies is still a matter of controversial discussions.

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Authors: Fötisch, K., & Vieths*, S.
Affiliations: Paul Ehrlich Institut (DE)
Venue: Glycoconjugate Journal
Publisher: Springer Science and Business Media LLC
Published: 2001-05
Volume: 18
Issue: 5
Pages: 373-390
ISSN: 0282-0080 (ISSN-L)
1573-4986
DOI: 10.1023/a:1014860030380
OpenAlex: W156274875
Cited by: 118
References: 130
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 10 · 2014: 7 · 2013: 5 · 2012: 5
FWCI: 0.42
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Glycoconjugate Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords: N-glycans, O-linked oligosaccharides, IgE epitopes, allergic rhinitis, allergic reactions
MeSH terms: Allergens, Animals, Epitopes, Carbohydrate Conformation, Carbohydrate Sequence, Glycoproteins, Humans, Immunoglobulin E, Models, Molecular, Molecular Sequence Data, Oligosaccharides, Protein Conformation

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N- and O-linked oligosaccharides of allergenic glycoproteins

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