Catheter ablation of inducible atrial flutter, in combination with atrial pacing and antiarrhythmic drugs ("hybrid therapy") improves rhythm control in patients with refractory atrial fibrillation
Abstract
Unlabelled Atrial flutter or tachycardia may coexist with atrial fibrillation [AF] and can be treated with ablation techniques in attempt to reduce the total AF burden. The role of ablation of latent atrial tachyarrhythmias elicited at electrophysiologic study in conjunction with atrial pacing and antiarrhythmic drugs in patients with refractory AF has not been evaluated. We evaluated the efficacy of catheter ablation of electrically induced atrial flutter or atrial tachycardia in improving rhythm control in patients with refractory AF. Methods Consecutive patients with refractory AF, and spontaneous atrial flutter (Group 1) or without spontaneous atrial flutter (Group 2) underwent programmed stimulation in a baseline drug-free state. All patients had electrically induced atrial flutter or tachycardia. Radiofrequency ablation of the arrhythmia substrate was performed in all patients. Primary endpoints evaluated for patient outcome in both groups included maintenance of rhythm control and freedom from recurrent atrial tachyarrhythmias. Results Forty-three patients, with a mean age of 66 +/- 13 years were studied. Group 1 consisted of 22 patients while Group 2 had 21 patients. Ablation of the tricuspid valve-inferior venacaval isthmus was performed in 41 patients who had common atrial flutter induced at electrophysiologic study. Ablation of other atrial sites was performed in 8 patients with induced atypical flutter and 4 patients with induced atrial tachycardia. Ten of these p…
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Combining cavotricuspid isthmus ablation and antiarrhythmic drugs may lead to improved rhythm control without the need for left atrial ablation in patients who develop 'drug-induced atrial flutter' on therapy with flecainide, propafenone, or amiodarone.
“Combining cavotricuspid isthmus ablation and antiarrhythmic drugs may lead to improved rhythm control without the need for left atrial ablation in patients who develop 'drug-induced atrial flutter' on therapy with flecainide, propafenone, or amiodarone, [834][835][836]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [834]
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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- Authors
- Prakash, A., Saksena, S., Krol, R. B., Filipecki, A., & Philip, G.
- Affiliations
- Atlantic Health System (US)
- Corresponding author
- Saksena, Sanjeev
- Venue
- Journal of Interventional Cardiac Electrophysiology
- Published
- 2002-06
- Volume
- 6
- Issue
- 2
- Pages
- 165-172
- ISSN
- 1383-875X (ISSN-L)
- 1572-8595
- OpenAlex
- W300902243
- Cited by
- 21
- References
- 25
- Citations by year
- 2024: 1 · 2023: 1 · 2016: 3 · 2014: 1 · 2012: 1
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Interventional Cardiac Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- refractory atrial fibrillation, atrial flutter, catheter ablation, radiofrequency ablation, atrial pacing, antiarrhythmic drugs, hybrid therapy, programmed electrical stimulation, atrial tachycardia, rhythm control, arrhythmia recurrence
- MeSH terms
- Aged, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Cardiac Pacing, Artificial, Female, Humans, Male, Middle Aged, Recurrence, Catheter Ablation, Electrophysiologic Techniques, Cardiac
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