Failure of hybrid therapy for the prevention of long-term recurrence of atrial fibrillation

García Seara, Javier; Raposeiras Roubin, Sergio; Gude Sampedro, Francisco; Balboa Barreiro, Vanessa; Martínez Sande, Jose L.; Rodríguez Mañero, Moisés; González Juanatey, José Ramón

doi:10.1016/j.ijcard.2014.06.042

Cited by 9Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

Failure of hybrid therapy for the prevention of long-term recurrence of atrial fibrillation

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García Seara, Javier, Raposeiras Roubin, Sergio, Gude Sampedro, Francisco, Balboa Barreiro, Vanessa, Martínez Sande, Jose L., Rodríguez Mañero, Moisés, González Juanatey, José Ramón·2014·International Journal of Cardiology

DOI 10.1016/j.ijcard.2014.06.042

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Abstract

Objectives To determine the long-term effectiveness of hybrid therapy in the control of atrial fibrillation (AF) as well as the differences in clinical outcomes between patients with antiarrhythmic drug atrial flutter (AAD-AFl), those with coexistent AFl and AF, and isolated AFl.Methods Four hundred eight patients who consecutively underwent cavotricuspid isthmus (CTI) ablation between 1998 and 2010 were followed for 5.9 years. Twenty-seven patients had AAD-AF1 (Group 1): they had AF but not AFl at baseline but on AAD therapy they showed typical AFl. They underwent CTI ablation and continued with AAD therapy, 96 patients had coexistent AF1 and AF at baseline (Group 2) and continued with AAD therapy at the discretion of their cardiologists and 284 patients had isolated AFl (Group 3).Results AF recurred in the majority of the AAD-AF1 patients (74%, incident density rate (IDR): 19.1/100 person-years). This incidence rate was similar to the recurrence rate of AF in patients with coexistent AFl and AF (59%, IDR: 19.2/100 person-years). The patients in Group 1 had a similar IDR of stroke as Group 2 and a slightly higher rate than Group 3. There were no significant differences in the IDR for death among Groups 1, 2 and 3.Conclusions Hybrid therapy was not effective for long-term control of AF. The clinical outcomes (AF, stroke and death) were similar for AAD-AF1 patients and patients with coexistent AF and AFl.

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Recurrent AF is a concern in the long term after combining cavotricuspid isthmus ablation and antiarrhythmic drugs.
“although recurrent AF is a concern in the long term.837, 838”
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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RETRACTED ARTICLE: Long-term mortality prediction of CHA2DS2VASc and HATCH scores in a cohort of patients with typical atrial flutter
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Ablacja cieśni trójdzielno-żylnej wśród pacjentów z przetrwałym migotaniem przedsionków jako terapia pomostowa celem utrzymania rytmu zatokowego — badanie pilotażowe
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Long-term outcome prediction of CHA2DS2VASc and HATCH scores in a cohort of patients with typical atrial flutter
García‐Seara, J., Gudé, F., Raposeiras‐Roubín, S., Martínez‐Sande, J. L., Melchor, L. G., Rodríguez‐Mañero, M., Fernández-López, X. A., Cruz, N. B., López-López, A., Álvarez, B. Á., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.105 · Cited by 1 · see citing works
The clinical outcomes of patients who developed typical atrial flutter on class 1C anti arrhythmic medications treated with hybrid approach
Grossman, L., Katz, M., Beinart, R., & Nof, E. (2019) · Clinical Cardiology · doi:10.1002/clc.23193
Long-term mortality prediction of CHA2DS2VASc and HATCH scores in a cohort of patients with typical atrial flutter
García‐Seara, J. (2015) · Clinical Research in Cardiology

Nearly uniform failure of atrial flutter ablation and continuation of antiarrhythmic agents (hybrid therapy) for the long-term control of atrial fibrillation
Anastasio, N., Frankel, D. S., Deyell, M. W., Zado, E., Gerstenfeld, E. P., Dixit, S., Cooper, J., Lin, D., Marchlinski, F. E., & Callans, D. J. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9679-0 · Cited by 15 · see citing works
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Kim, J., Choi, S., Joung, B., Lee, M., & Kim, S. S. (2011) · Yonsei Medical Journal · doi:10.3349/ymj.2012.53.1.76 · Cited by 1 · see citing works
P343Prognostic value of clinical and electrophysiological parameters in patients undergoing hybrid therapy for coexisting typical atrial flutter and atrial fibrillation
Новиков, П. С., Певзнер, А. В., Борисович, Ш. Н., Maykov, E. B., Mironov, N. U., Sokolov, S. V., & Golitsyn, S. F. (2018) · EP Europace · doi:10.1093/europace/euy015.154
Hybrid atrial fibrillation ablation: long-term outcomes from a single-centre 10-year experience
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Authors: García Seara, J., Raposeiras Roubin, S., Gude Sampedro, F., Balboa Barreiro, V., Martínez Sande, J. L., Rodríguez Mañero, M., & González Juanatey, J. R.
Venue: International Journal of Cardiology
Publisher: Elsevier BV
Published: 2014-09
Volume: 176
Issue: 1
Pages: 74-79
ISSN: 0167-5273 (ISSN-L)
DOI: 10.1016/j.ijcard.2014.06.042
OpenAlex: W2031835835
Cited by: 9
References: 28
Citations by year: 2019: 1 · 2017: 1 · 2016: 4 · 2015: 3
FWCI: 1.83
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, atrial flutter, hybrid therapy, antiarrhythmic drugs, cavotricuspid isthmus ablation, atrial fibrillation recurrence, stroke, mortality, long-term outcomes
MeSH terms: Aged, Aged, 80 and over, Anti-Arrhythmia Agents, Atrial Fibrillation, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survival Rate, Treatment Outcome, Catheter Ablation, Treatment Failure

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Failure of hybrid therapy for the prevention of long-term recurrence of atrial fibrillation

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