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Cited by 146Nanoparticle-Based Drug DeliveryHIV Research and TreatmentAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting

Schäfer, Volker, von Briesen, Hagen, Andreesen, Reinhard, Steffan, Anne-Marie, Royer, Cathy, Tröster, Sabine, Kreuter, Jörg, Rübsamen-Waigmann, Helga·1992·Pharmaceutical Research
DOI 10.1023/a:1015852732512
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Abstract

Human monocytes/macrophages (MO/MAC) were isolated from peripheral blood and cultivated on hydrophobic Teflon membranes. This culture system is suitable for HIV infection of MO/MAC in vitro. After transfer into 24-well plates the mature macrophages (infected or uninfected) were used for measurements of phagocytosis. The uptake of different, radioactively labeled nanoparticles (NP) made of polyalkylcyanoacrylate, polymethylmethacrylate (PMMA), and human serum albumin (HSA) by the macrophages was determined. In addition, the influence on phagocytosis of size and composition, concentration, and surface of the NP was studied. Further, macrophages of different state of activation were tested. NP made of polyhexylcyanoacrylate (PHCA) or human serum albumin with a diameter of about 200 nm were found most useful for targeting antiviral substances such as azidotymidine to macrophages. Cells infected in vitro with HIV-1D117/III, a monocytotropic HIV isolate from a perinatally infected child, possessed an even higher phagocytotic activity than noninfected cells. Macrophages isolated from HIV-infected patients also showed good incorporation of NP. Thus, the concept of a specific targeting of antiviral substances to macrophages in HIV-infected individuals appears quite promising.

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Crossref · 10.1023/a:1015852732512

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Research works printed but not linked: 5

  1. R. van Furth. Phagocytic cells. Development and distribution of mononuclear phagocytes in normal steady state and inflammation. In J. Gallen, M. Golstein, and R. Snyderman (eds.), Inflammation, Raven Press, New York, 1988, p. 281.
  2. C. Scheibenbogen, W. Brugger, C. Rordorf, and R. Andreesen. Developmental regulation and stimulus specificity of cytokine release by human macrophages. Exp. Cell Biol. 57:118 (1989).
  3. D. L. Munz, R. Standke, and G. Hör. Measurement of phagocytic and proteolytic function of macrophages in liver, spleen and bone marrow. In P. H. Cox (ed.), Progress in Radiopharmacology 2:261–266 (1981).
  4. Centers for Disease Control (CDC). Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Morbid. Mortal. Week. Rep. 37(suppl. no. 1S):3S–15S (1987).
  5. J. Kreuter. Evaluation of nanoparticles as a drug delivery system I. J. Pharm. Acta Helv. 58:196–208 (1983).

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Metadata

Authors
Schäfer, V., von Briesen, H., Andreesen, R., Steffan, A.-M., Royer, C., Tröster, S., Kreuter, J., & Rübsamen-Waigmann, H.
Affiliations
  • Goethe University Frankfurt (DE)
  • University of Freiburg (DE)
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
1992-04
Volume
9
Issue
4
Pages
541-546
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/a:1015852732512
OpenAlex
W1498773598
Cited by
146
References
20
Citations by year
2026: 4 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 8
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
phagocytosis, nanoparticles, HIV-infected macrophages, human serum albumin, poly(methyl methacrylate), macrophage activation, HIV-1, monocytes/macrophages
MeSH terms
Antiviral Agents, Cells, Cultured, HIV, Humans, Macrophages, Microscopy, Electron, Scanning, Phagocytosis

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