The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting
Abstract
Human monocytes/macrophages (MO/MAC) were isolated from peripheral blood and cultivated on hydrophobic Teflon membranes. This culture system is suitable for HIV infection of MO/MAC in vitro. After transfer into 24-well plates the mature macrophages (infected or uninfected) were used for measurements of phagocytosis. The uptake of different, radioactively labeled nanoparticles (NP) made of polyalkylcyanoacrylate, polymethylmethacrylate (PMMA), and human serum albumin (HSA) by the macrophages was determined. In addition, the influence on phagocytosis of size and composition, concentration, and surface of the NP was studied. Further, macrophages of different state of activation were tested. NP made of polyhexylcyanoacrylate (PHCA) or human serum albumin with a diameter of about 200 nm were found most useful for targeting antiviral substances such as azidotymidine to macrophages. Cells infected in vitro with HIV-1D117/III, a monocytotropic HIV isolate from a perinatally infected child, possessed an even higher phagocytotic activity than noninfected cells. Macrophages isolated from HIV-infected patients also showed good incorporation of NP. Thus, the concept of a specific targeting of antiviral substances to macrophages in HIV-infected individuals appears quite promising.
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“The phenomenon appears to mirror that of phagocytosis, where macrophages preferentially internalize particulates in the micron range over the nanometric range, with peak phagocytosis observed with particles of approximately 2 μm in diameter [46-48].”
From Characterization of topographical effects on macrophage behavior in a foreign body response model (2010) · cites this paper as [47]
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Cites
Gendelman, H. E., Orenstein, J. M., Martin, M. A., Ferrua, C., Mitra, R., Phipps, T. J., Wahl, L. A., Lane, H. C., Fauci, A. S., & Burke, D. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1428 · Cited by 781
Johnston, R. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181205 · Cited by 697
Nanoparticles--a new colloidal drug delivery system.
Marty, J. J., Oppenheim, R. C., & Speiser, P. P. (1978) · PubMed · Cited by 337
Magnetic Microspheres: Synthesis of a Novel Parenteral Drug Carrier
Widder, K. J., Flouret, G. R., & Senyei, A. E. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600680124 · Cited by 195
Macrophages and the human immunodeficiency virus
Meltzer, M. S., Skillman, D. R., Hoover, D. L., Hanson, B. D., Turpin, J. A., Kalter, D. C., & Gendelman, H. E. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90086-o · Cited by 168
Primary cultures of human blood-born macrophages grown on hydrophobic teflon membranes
Andreesen, R., Picht, J., & Löhr, G. W. (1983) · Journal of Immunological Methods · doi:10.1016/s0022-1759(83)80019-2 · Cited by 164
Self-citationTröster, S. D., Müller, U., & Kreuter, J. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90047-8 · Cited by 163
Self-citationAndreesen, R., Bross, K., Osterholz, J., & Emmrich, F. (1986) · Blood · doi:10.1182/blood.v67.5.1257.1257 · Cited by 137
Self-citationRoy, S., & Wainberg, M. A. (1988) · Journal of Leukocyte Biology · doi:10.1002/jlb.43.1.91 · Cited by 113
Kreuter, J., Täuber, U., & Illi, V. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600681129 · Cited by 109
Self-citationLeu, D., Manthey, B., Kreuter, J., Speiser, P. P., & Delucax, P. P. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600731028 · Cited by 88
Self-citationRübsamen‐Waigmann, H., Becker, W. B., Helm, E. B., Brodt, R. H., Fischer, H., Henco, K., & Brede, H. D. (1986) · Journal of Medical Virology · doi:10.1002/jmv.1890190406 · Cited by 73
Self-citationKühnel, H., von Briesen, H., Dietrich, U., Adamski, M., Mix, D., BIESERT, L., Kreutz, R., Immelmann, A., Henco, K., & Meichsner, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2383 · Cited by 71
Waser, P. G., Müller, U., Kreuter, J., Berger, S., Munz, K., Kaiser, E., & Pfluger, B. (1987) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(87)90219-5 · Cited by 58
Self-citationSecretory Repertoire of HIV-Infected Human Monocytes/Macrophages
Esser, R., VONBRIESEN, H., Brugger, W., Ceska, M., Glienke, W., ller, S. M. U., Rehm, A., Rübsamen‐Waigmann, H., & Andreesen, R. (2008) · Pathobiology · doi:10.1159/000163649 · Cited by 50
Self-citationPhagocytosis of Bioactive Microspheres
Ikada, Y., & Tabata, Y. (1986) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391158600100104 · Cited by 44
Infection of monocytes/macrophages by HIV in vitro
von Briesen, H., Andreesen, R., Esser, R., Brugger, W., Meichsner, C., Becker, K., & Rübsamen‐Waigmann, H. (1990) · Research in Virology · doi:10.1016/0923-2516(90)90025-e · Cited by 43
Self-citationREVERSAL OF HIV-PHENOTYPE TO FULMINANT REPLICATION ON MACROPHAGES IN PERINATAL TRANSMISSION
Rübsamen‐Waigmann, H., Willems, W. R., Bertram, U., & von Briesen, H. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91518-3 · Cited by 37
Self-citationClassification of Infections with Human Immunodeficiency Virus
Burke, D. S., & Redfield, R. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-968_1 · Cited by 11
Scintigraphy of Lymphokinetics and Lymphatic Neoplasia
Hör, G., Munz, D. L., Brandhorst, I., Maul, F. D., Holzmann, H., Altmeyer, P. J., & Baum, R. P. (1986) · Springer eBooks · doi:10.1007/978-3-642-70947-0_16 · Cited by 6
Research works printed but not linked: 5
- R. van Furth. Phagocytic cells. Development and distribution of mononuclear phagocytes in normal steady state and inflammation. In J. Gallen, M. Golstein, and R. Snyderman (eds.), Inflammation, Raven Press, New York, 1988, p. 281.
- C. Scheibenbogen, W. Brugger, C. Rordorf, and R. Andreesen. Developmental regulation and stimulus specificity of cytokine release by human macrophages. Exp. Cell Biol. 57:118 (1989).
- D. L. Munz, R. Standke, and G. Hör. Measurement of phagocytic and proteolytic function of macrophages in liver, spleen and bone marrow. In P. H. Cox (ed.), Progress in Radiopharmacology 2:261–266 (1981).
- Centers for Disease Control (CDC). Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Morbid. Mortal. Week. Rep. 37(suppl. no. 1S):3S–15S (1987).
- J. Kreuter. Evaluation of nanoparticles as a drug delivery system I. J. Pharm. Acta Helv. 58:196–208 (1983).
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Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Encapsulation of polyphenols – a review
Fang, Z., & Bhandari, B. (2010) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2010.08.003 · Cited by 1,589
Nanocarriers’ entry into the cell: relevance to drug delivery
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Nanoparticle uptake: The phagocyte problem
Gustafson, H. H., Holt‐Casper, D., Grainger, D. W., & Ghandehari, H. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.006 · Cited by 1,458
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Metadata
- Authors
- Schäfer, V., von Briesen, H., Andreesen, R., Steffan, A.-M., Royer, C., Tröster, S., Kreuter, J., & Rübsamen-Waigmann, H.
- Affiliations
- Goethe University Frankfurt (DE)
- University of Freiburg (DE)
- Venue
- Pharmaceutical Research
- Published
- 1992-04
- Volume
- 9
- Issue
- 4
- Pages
- 541-546
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W1498773598
- Cited by
- 146
- References
- 20
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 8
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- phagocytosis, nanoparticles, HIV-infected macrophages, human serum albumin, poly(methyl methacrylate), macrophage activation, HIV-1, monocytes/macrophages
- MeSH terms
- Antiviral Agents, Cells, Cultured, HIV, Humans, Macrophages, Microscopy, Electron, Scanning, Phagocytosis
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