Cited by 388Intramuscular injections and effectsAdvanced Drug Delivery SystemsLymphatic System and Diseases

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Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

Supersaxo, Andreas, Hein, Wayne R., Steffen, Hans·1990·Pharmaceutical Research

DOI 10.1023/a:1015880819328

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Abstract

The lymphatic absorption of four water-soluble compounds with different molecular weights (MW) was determined by measuring their cumulative recovery in lymph draining from the site of s.c. administration in sheep. The cumulative recoveries (% of dose, mean +/- SD; N = 3) were 4.0 +/- 1.5 (5-fluoro-2'-deoxyuridine, MW 246.2), 21.0 +/- 7.1 (inulin, MW 5200), 38.6 +/- 6.7 (cytochrome c, MW 12,300), and 59.5 +/- 7.7 [human recombinant interferon (rIFN) alpha-2a, MW 19,000], respectively. Our data show that in the investigated MW range, there is a linear relationship between the molecular weight and the proportion of the dose absorbed lymphatically. An increase in molecular weight results in an increased lymphatic absorption. Molecules with MW greater than 16,000 are absorbed mainly by the lymphatics which drain the application site. The knowledge gained in this investigation may help to improve the mode of administration and therapeutic efficacy of endogenous proteins whose targets are lymphoid cells (e.g., interferons, interleukins). Practical implications for the clinical use of such proteins are discussed.

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Authors: Supersaxo, A., Hein, W. R., & Steffen, H.
Affiliations: F. Hoffmann-La Roche AG (CH)
ORCID: Hein, Wayne R.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 1990-02
Volume: 7
Issue: 2
Pages: 167-169
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1023/a:1015880819328
OpenAlex: W1586699825
Cited by: 386
References: 14
Citations by year: 2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 29 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 9 · 2016: 11 · 2015: 20 · 2014: 10 · 2013: 20 · 2012: 25
FWCI: 5.21
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: lymphatic absorption, molecular weight, subcutaneous administration, water-soluble compounds, lymphatic drainage, 5-fluorodeoxyuridine, inulin, cytochrome c, interferon alfa-2a, sheep, lymphatic drug delivery
MeSH terms: Absorption, Animals, Chemistry, Physical, Female, Floxuridine, Injections, Subcutaneous, Insulin, Interferon Type I, Lymphatic System, Male, Molecular Weight, Recombinant Proteins, Sheep, Solubility, Chemical Phenomena

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Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

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