Cited by 388Intramuscular injections and effectsAdvanced Drug Delivery SystemsLymphatic System and Diseases

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Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

Supersaxo, Andreas, Hein, Wayne R., Steffen, Hans·1990·Pharmaceutical Research

DOI 10.1023/a:1015880819328

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Abstract

The lymphatic absorption of four water-soluble compounds with different molecular weights (MW) was determined by measuring their cumulative recovery in lymph draining from the site of s.c. administration in sheep. The cumulative recoveries (% of dose, mean +/- SD; N = 3) were 4.0 +/- 1.5 (5-fluoro-2'-deoxyuridine, MW 246.2), 21.0 +/- 7.1 (inulin, MW 5200), 38.6 +/- 6.7 (cytochrome c, MW 12,300), and 59.5 +/- 7.7 [human recombinant interferon (rIFN) alpha-2a, MW 19,000], respectively. Our data show that in the investigated MW range, there is a linear relationship between the molecular weight and the proportion of the dose absorbed lymphatically. An increase in molecular weight results in an increased lymphatic absorption. Molecules with MW greater than 16,000 are absorbed mainly by the lymphatics which drain the application site. The knowledge gained in this investigation may help to improve the mode of administration and therapeutic efficacy of endogenous proteins whose targets are lymphoid cells (e.g., interferons, interleukins). Practical implications for the clinical use of such proteins are discussed.

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The human interferons—From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond
Pestka, S. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90118-2 · Cited by 236
THE OUTPUT OF CELLS IN LYMPH FROM THE POPLITEAL NODE OF SHEEP
Hall, J. G., & Morris, B. (1962) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1962.sp001620 · Cited by 227
Theory and practice of site-specific drug delivery
Tomlinson, E. (1987) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(87)90001-9 · Cited by 148
STUDIES ON THE PERMEABILITY OF LYMPHATIC CAPILLARIES
Leak, L. V. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.2.300 · Cited by 147
The physiological interferon response
Bocci, V. A. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90159-8 · Cited by 77
Roles of interferon produced in physiological conditions. A speculative review.
Bocci, V. A. (1988) · PubMed Central · Cited by 75
Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application
Supersaxo, A., Hein, W., Gallati, H., & Steffen, H. (1988) · Pharmaceutical Research · doi:10.1023/a:1015957022073 · Cited by 46
Self-citation
Monoclonal antitumor antibodies in the lymphatics.
Weinstein, J. N., Steller, M. A., Covell, D. G., Holton, O. D., Keenan, A. M., Sieber, S. M., & Parker, R. (1984) · PubMed · Cited by 40
THE PERMEABILITY OF THE CAPILLARIES OF THE DOG TO PROTEIN
Field, M. E., & Drinker, C. K. (1931) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1931.97.1.40 · Cited by 37
Sheep as an Experimental Model for Immunology: Immunological Techniques in Vitro and in Vivo
Miyasaka, M., & Trnka, Z. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-442703-7.50030-9 · Cited by 36

Show all 14 references

Research works printed but not linked: 5

J. N. Weinstein, M. A. Steller, D. G. Covell, O. D. Holton, A. M. Keenan, S. M. Sieber, and R. J. Parker. Cancer Treat. Rep. 68:257–264 (1984).
H. Gallati. J. Clin. Chem. Clin. Biochem. 22:907–914 (1982).
C. C. C. O'Morchoe and P. J. O'Morchoe. Lymphology 20:205–209 (1987).
G. Poste. Proc. Int. Symp. Control. Rel. Bioact. Mater. 15:1–2 (1988).
V. Bocci. Immunology 64:1–9 (1988).

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Authors: Supersaxo, A., Hein, W. R., & Steffen, H.
Affiliations: F. Hoffmann-La Roche AG (CH)
ORCID: Hein, Wayne R.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 1990-02
Volume: 7
Issue: 2
Pages: 167-169
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1023/a:1015880819328
OpenAlex: W1586699825
Cited by: 386
References: 14
Citations by year: 2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 29 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 9 · 2016: 11 · 2015: 20 · 2014: 10 · 2013: 20 · 2012: 25
FWCI: 5.21
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: lymphatic absorption, molecular weight, subcutaneous administration, water-soluble compounds, lymphatic drainage, 5-fluorodeoxyuridine, inulin, cytochrome c, interferon alfa-2a, sheep, lymphatic drug delivery
MeSH terms: Absorption, Animals, Chemistry, Physical, Female, Floxuridine, Injections, Subcutaneous, Insulin, Interferon Type I, Lymphatic System, Male, Molecular Weight, Recombinant Proteins, Sheep, Solubility, Chemical Phenomena

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

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