Cited by 388Intramuscular injections and effectsAdvanced Drug Delivery SystemsLymphatic System and Diseases

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

Supersaxo, Andreas, Hein, Wayne R., Steffen, Hans·1990·Pharmaceutical Research

DOI 10.1023/a:1015880819328

Open this paper in CoChat — free account

Abstract

The lymphatic absorption of four water-soluble compounds with different molecular weights (MW) was determined by measuring their cumulative recovery in lymph draining from the site of s.c. administration in sheep. The cumulative recoveries (% of dose, mean +/- SD; N = 3) were 4.0 +/- 1.5 (5-fluoro-2'-deoxyuridine, MW 246.2), 21.0 +/- 7.1 (inulin, MW 5200), 38.6 +/- 6.7 (cytochrome c, MW 12,300), and 59.5 +/- 7.7 [human recombinant interferon (rIFN) alpha-2a, MW 19,000], respectively. Our data show that in the investigated MW range, there is a linear relationship between the molecular weight and the proportion of the dose absorbed lymphatically. An increase in molecular weight results in an increased lymphatic absorption. Molecules with MW greater than 16,000 are absorbed mainly by the lymphatics which drain the application site. The knowledge gained in this investigation may help to improve the mode of administration and therapeutic efficacy of endogenous proteins whose targets are lymphoid cells (e.g., interferons, interleukins). Practical implications for the clinical use of such proteins are discussed.

Integrity signals

Registry

Crossref · 10.1023/a:1015880819328

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The human interferons—From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond
Pestka, S. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90118-2 · Cited by 236
THE OUTPUT OF CELLS IN LYMPH FROM THE POPLITEAL NODE OF SHEEP
Hall, J. G., & Morris, B. (1962) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1962.sp001620 · Cited by 227
Theory and practice of site-specific drug delivery
Tomlinson, E. (1987) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(87)90001-9 · Cited by 148
STUDIES ON THE PERMEABILITY OF LYMPHATIC CAPILLARIES
Leak, L. V. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.2.300 · Cited by 147
The physiological interferon response
Bocci, V. A. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90159-8 · Cited by 77
Roles of interferon produced in physiological conditions. A speculative review.
Bocci, V. A. (1988) · PubMed Central · Cited by 75
Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application
Supersaxo, A., Hein, W., Gallati, H., & Steffen, H. (1988) · Pharmaceutical Research · doi:10.1023/a:1015957022073 · Cited by 46
Self-citation
Monoclonal antitumor antibodies in the lymphatics.
Weinstein, J. N., Steller, M. A., Covell, D. G., Holton, O. D., Keenan, A. M., Sieber, S. M., & Parker, R. (1984) · PubMed · Cited by 40
THE PERMEABILITY OF THE CAPILLARIES OF THE DOG TO PROTEIN
Field, M. E., & Drinker, C. K. (1931) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1931.97.1.40 · Cited by 37
Sheep as an Experimental Model for Immunology: Immunological Techniques in Vitro and in Vivo
Miyasaka, M., & Trnka, Z. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-442703-7.50030-9 · Cited by 36

Show all 14 references

Research works printed but not linked: 5

J. N. Weinstein, M. A. Steller, D. G. Covell, O. D. Holton, A. M. Keenan, S. M. Sieber, and R. J. Parker. Cancer Treat. Rep. 68:257–264 (1984).
H. Gallati. J. Clin. Chem. Clin. Biochem. 22:907–914 (1982).
C. C. C. O'Morchoe and P. J. O'Morchoe. Lymphology 20:205–209 (1987).
G. Poste. Proc. Int. Symp. Control. Rel. Bioact. Mater. 15:1–2 (1988).
V. Bocci. Immunology 64:1–9 (1988).

Items 201–300 of 388

Clinical Pharmacokinetics and Pharmacodynamics of Erythropoiesis-Stimulating Agents
Doshi, S., Krzyżański, W., Yue, S. V., Elliott, S. G., Chow, A. T., & Ruixo, J. J. P. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0098-x · Cited by 20
Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
Zou, Y., Bateman, T. J., Adreani, C. M., Shen, X., Cunningham, P. K., Wang, B., Trinh, T., Christine, A., Hong, X., da Silva, C. N., et al. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.051524 · Cited by 20
Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents
Li, C., Xu, X., McMahon, N. P., Ibrahim, O. A., Sattar, H. A., & Tichauer, K. M. (2019) · Contrast Media & Molecular Imaging · doi:10.1155/2019/7561862 · Cited by 20
Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy
Longobardi, G., Moore, T. L., Conte, C., Ungaro, F., Satchi‐Fainaro, R., & Quaglia, F. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1990 · Cited by 19
Delivery Systems for Lymphatic Targeting
Singh, I., Swami, R., Khan, W., & Sistla, R. (2013) · Advances in delivery science and technology · doi:10.1007/978-1-4614-9434-8_20 · Cited by 19
Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM
Brito, P. K. M. O., Gonçalves, T. E., Fernandes, F. F., Miguel, C. B., Rodrigues, W. F., Chica, J. E. L., Roque‐Barreira, M. C., & da Silva, T. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187151 · Cited by 19
Noninvasive detection of cancer spread to lymph nodes: A review of molecular imaging principles and protocols
Li, C., Torres, V. C., & Tichauer, K. M. (2018) · Journal of Surgical Oncology · doi:10.1002/jso.25124 · Cited by 19
Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide
Offman, E. M., Phipps, C. J., & Edginton, A. N. (2016) · In Silico Pharmacology · doi:10.1186/s40203-016-0018-5 · Cited by 19
In Vitro/in Vivo Correlation for 14C-Methylated Lysozyme Release from Poly(Ether-Ester) Microspheres
van Dijkhuizen-Radersma, R., Wright, S., Taylor, L. C., John, B. A., de Groot, K., & Bezemer, J. M. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000019303.12086.d1 · Cited by 18
Molecular Dynamics of Multivalent Soluble Antigen Arrays Support a Two-Signal Co-delivery Mechanism in the Treatment of Experimental Autoimmune Encephalomyelitis
Hartwell, B. L., Hall, A. S., Swafford, D., Sullivan, B. P., Garza, A., Sestak, J. O., Northrup, L., & Berkland, C. J. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00825 · Cited by 17
Biodistribution and Lymphatic Tracking of the Main Neurotoxin of Micrurus fulvius Venom by Molecular Imaging
Vergara, I., Castillo, E., Romero-Piña, M., Torres-Viquez, I., Paniagua, D., Boyer, L., Alagon, A. C., & Medina, L. A. (2016) · Toxins · doi:10.3390/toxins8040085 · Cited by 17
Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics
Meibohm, B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6486-0_5 · Cited by 17
Development of an In Vitro System To Emulate an In Vivo Subcutaneous Environment: Small Molecule Drug Assessment
Lou, H., & Hageman, M. J. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00490 · Cited by 16
Use of In Vitro Human Skin Membranes to Model and Predict the Effect of Changing Blood Flow on the Flux and Retention of Topically Applied Solutes
Cross, S. E., & Roberts, M. S. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21253 · Cited by 16
Insulin
Beals, J. M., DeFelippis, M. R., Paavola, C. D., Allen, D. P., Garg, A. K., & Baldwin, D. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-00710-2_18 · Cited by 16
Recombinant Factor VIII SQ—Stability of VIII: C in Homogenates from Porcine, Monkey and Human Subcutaneous Tissue
Fatouros, A., Lidén, Y., & Sjöström, B. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774651 · Cited by 16
Utilization of Stimuli-Responsive Biomaterials in the Formulation of Cancer Vaccines
Singh, A. K., Malviya, R., Prajapati, B. G., Singh, S. K., & Goyal, P. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14050247 · Cited by 16
Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins
Meibohm, B. (2019) · Springer eBooks · doi:10.1007/978-3-030-00710-2_6 · Cited by 15
Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations
Chiang, P., Nagapudi, K., Fan, P. W., & Liu, J. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.06.003 · Cited by 15
Development of gene therapy-based strategies for the treatment of eye diseases
Rakoczy, P. E., Shen, W., Lai, M. C., Rolling, F., & Constable, I. J. (1999) · Drug Development Research · doi:10.1002/(sici)1098-2299(199903/04)46:3/4<206::aid-ddr6>3.0.co;2-4 · Cited by 11
Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model
Connor, R., Clift, R., & Kang, D. W. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2252999 · Cited by 14
Breaking barriers: Innovative approaches for skin delivery of RNA therapeutics
Subramanian, G., Kalidasan, K., Quah, S., Qi Chou, G. H., Chan, J., Wacker, M. G., & Sampath, P. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124435 · Cited by 14
Population Pharmacokinetics of Epcoritamab Following Subcutaneous Administration in Relapsed or Refractory B Cell Non-Hodgkin Lymphoma
Li, T. R., Gibiansky, L. V., Parikh, A., van der Linden, M., Sanghavi, K., Putnins, M., Sacchi, M., Feng, H., Ahmadi, T., Gupta, M., et al. (2024) · Clinical Pharmacokinetics · doi:10.1007/s40262-024-01464-2 · Cited by 14
Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation
Lin, X., Wang, Huang, Liang, L., Shen, Feng, & Ruan, ؉. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s26306 · Cited by 14
Broad variability in pharmacokinetics of GH following rhGH injections in children
Lundberg, E., Andersson, B., Kriström, B., Rosberg, S., & Albertsson-Wikland, K. G. (2018) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2018.01.004 · Cited by 14
Formulation of Biologics Including Biopharmaceutical Considerations
Crommelin, D. J. A., Hawe, A., & Jiskoot, W. (2019) · Springer eBooks · doi:10.1007/978-3-030-00710-2_5 · Cited by 14
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations
Esposito, S., Orsatti, L., & Pucci, V. (2022) · Xenobiotica · doi:10.1080/00498254.2022.2119180 · Cited by 13
A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes
Stader, F., Liu, C., Derbalah, A., Momiji, H., Pan, X., Gardner, I. B., Jamei, M., & Sepp, A. (2024) · Antibodies · doi:10.3390/antib13030070 · Cited by 13
Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques
Rosenberg, Y. J., Montefiori, D. C., LaBranche, C. C., Lewis, M. G., Sack, M., Lees, J. P., & Jiang, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152760 · Cited by 13
Recombinant VWF fragments improve bioavailability of subcutaneous factor VIII in hemophilia A mice
Vollack, N., Oleshko, O., Werwitzke, S., Solecka-Witulska, B., Kannicht, C., & Tiede, A. (2020) · Blood · doi:10.1182/blood.2020006468 · Cited by 13
Formulation of Biotech Products, Including Biopharmaceutical Considerations
Crommelin, D. J. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6486-0_4 · Cited by 13
Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach
Bei, R., Thomas, J. W., Kapur, S., Woldeyes, M. A., Rauk, A. P., Robarge, J., Feng, J., & Oucherif, K. A. (2024) · mAbs · doi:10.1080/19420862.2024.2352887 · Cited by 12
Insulin
Beals, J. M., DeFelippis, M. R., Kovach, P. M., & Jackson, J. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6486-0_12 · Cited by 12
Biologics: Delivery options and formulation strategies
Nongkhlaw, R., Patra, P., Chaurasiya, A., Nirmal, J., & Dubey, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821222-6.00006-3 · Cited by 12
Role of Lymphatic System on Snake Venom Absorption
Paniagua, D., Vergara, I., Boyer, L., & Alagón, A. (2015) · Springer eBooks · doi:10.1007/978-94-007-6648-8_10-1 · Cited by 12
A compartment model for subcutaneous injection of monoclonal antibodies
Zhong, X., Liu, Y., & Ardekani, A. M. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123687 · Cited by 11
Utility of an in vitro lymphatics on-chip model for rank ordering subcutaneous absorption of monoclonal antibodies
Ledo, A. M., Misiewicz, G., Dimke, T., Tschantz, W. R., Handel, J., Pelis, R. M., Bruin, G. J. M., Bechtold-Peters, K., Sánchez-Félix, M., Deshmukh, S. V., et al. (2025) · Lab on a Chip · doi:10.1039/d4lc00988f · Cited by 11
Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture
Perazzolo, S., Shireman, L. M., Shen, D. D., & Ho, R. J. Y. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.10.007 · Cited by 11
Challenging the Norm: A Multidisciplinary Perspective on Intravenous to Subcutaneous Bridging Strategies for Biologics
Ait‐Oudhia, S., Wang, Y., Dosne, A., Roy, A., Jin, J. Y., Shen, J., Kagan, L., Musuamba, F. T., Zhang, L., Kijima, S., et al. (2023) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3133 · Cited by 11
Prevention of Polyglycolic Acid-Induced Peritoneal Adhesions Using Alginate in a Rat Model
Matoba, M., Hashimoto, A., Tanzawa, A., Orikasa, T., Ikeda, J., Iwame, Y., Ozamoto, Y., Abe, R., Miyamoto, H., Yoshida, C., et al. (2015) · BioMed Research International · doi:10.1155/2015/403413 · Cited by 11
Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals
Knadler, M. P., Nguyen, T., Campanale, K. M., de Veer, M. J., Beals, J. M., Li, S., Hansen, R. J., Siesky, A. M., Michael, M. D., & Porter, C. J. H. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-2014-1 · Cited by 11
A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats
Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D. P., Tachedjian, G., & Ascher, D. B. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.03.008 · Cited by 11
Long‐Duration and Non‐Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent
Khadria, A., Paavola, C. D., Zhang, Y., Davis, S., Grealish, P. F., Maslov, K., Shi, J., Beals, J. M., Oladipupo, S. S., & Wang, L. V. (2022) · Advanced Science · doi:10.1002/advs.202202907 · Cited by 11
Development of a Prophylactic Butyrylcholinesterase Bioscavenger to Protect Against Insecticide Toxicity Using a Homologous Macaque Model
Rosenberg, Y. J., Jiang, X., Mao, L., Hernandez, S., & Lee, K. (2012) · InTech eBooks · doi:10.5772/29014 · Cited by 11
Pharmacology of TNF inhibitors
Shukla, R., & Vender, R. B. (2006) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7438-1_3 · Cited by 11
Key Physicochemical Characteristics Influencing ADME Properties of Therapeutic Proteins
Jing, X., Hou, Y., Hallett, W. H. D., Sahajwalla, C. G., & Ji, P. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7709-9_6 · Cited by 11
Mechanism-Based Pharmacokinetic Modeling of Absorption and Disposition of a Deferoxamine-Based Nanochelator in Rats
Jones, G. T., Zeng, L., & Kim, J. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00737 · Cited by 10
Clinical Utility of Subcutaneous Factor VIII Replacement Therapies in Hemophilia A: A Review of the Evidence
Dargaud, Y. G., & Janbain, M. (2021) · Journal of Blood Medicine · doi:10.2147/jbm.s260923 · Cited by 10
Subcutaneous bioavailability of a PRIMATIZEDTMIgG1 Anti-Human CD4 monoclonal antibody is dose dependent in transgenic mice bearing human CD4
Davis, C. B., & Bugelski, P. J. (1998) · Drug Delivery · doi:10.3109/10717549809031384 · Cited by 10
Design of biological equivalence programs for therapeutic biotechnology products in clinical development: a perspective.
Mordenti, J. J., Cavagnaro, J. A., & Green, J. D. (1996) · Pharmaceutical Research · doi:10.1023/a:1016002823485 · Cited by 10
Drug delivery
Illum, L., & Davis, S. S. (1991) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(91)90018-z · Cited by 10
Treatment Innovations in Pancreatic Cancer: Putting Patient Priorities First
Reiss, K. A., Soares, K. C., Torphy, R. J., & Gyawali, B. (2025) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-25-473204 · Cited by 10
Clinical Qualification of Subcutaneous Injection Devices for Monoclonal Antibodies
Bittner, B., Munoz, J., Frank, S., Dolton, M. J., Ravanello, R., Dembowski, M., Clement, A., & Richter, W. F. (2025) · BioDrugs · doi:10.1007/s40259-025-00755-9 · Cited by 9
Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans
Kinvig, H., Rajoli, R. K. R., Pertinez, H. E., Vora, L. K., Volpe‐Zanutto, F., Donnelly, R. F., Rannard, S. P., Flexner, C. W., Siccardi, M., & Owen, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122709 · Cited by 9
Pharmacokinetics and pharmacodynamics of therapeutic antibodies in tumors and tumor-draining lymph nodes
Salgado, E., & Cao, Y. (2020) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2021006 · Cited by 9
Distribution and elimination of protein therapeutics: A review
Sutradhar, K. B., Khatun, S., Mamun, A. A., & Begum, M. (2012) · Stamford Journal of Pharmaceutical Sciences · doi:10.3329/sjps.v4i2.10433 · Cited by 9
Population pharmacokinetic modelling of subcutaneous morphine in the elderly
Upton, R. N., Semple, T. J., Macintyre, P. E., & Foster, D. J. R. (2006) · Acute Pain · doi:10.1016/j.acpain.2006.06.002 · Cited by 9
Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus
Tian, Y., Enioutina, E. Y., Brunner, H. I., Vinks, A. A. T. M. M., & Sherwin, C. M. T. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-016-0426-z · Cited by 10
On-body drug delivery systems: State-of-the-art technologies, clinical application, and future perspectives
Dorati, R., Cosco, D., Battaglia, L., Cirri, M., Conti, B., Borghi, T., Gabriele, M., Bruno, G. M., Rocco, P., Selmin, F., et al. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104441 · Cited by 8
Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S
Bhansali, S. G., Balu‐Iyer, S. V., & Morris, M. E. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22795 · Cited by 8
Application of Modeling and Simulation in the Development of Protein Drugs
Roskos, L. K., Ren, S., & Robbie, G. J. (2010) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4419-7415-0_17 · Cited by 8
Role of Lymphatic System on Snake Venom Absorption
Paniagua, D., Vergara, I., Boyer, L., & Alagón, A. (2017) · Springer eBooks · doi:10.1007/978-94-007-6410-1_10 · Cited by 8
Approaching the Next Inflection in Peptide Therapeutics: Attaining Cell Permeability and Oral Bioavailability
Ghodge1, S. V., Biswas2, K., & Golosov3, A. A. (2022) · ACS symposium series · doi:10.1021/bk-2022-1417 · Cited by 8
Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing
An, G., Ohls, R. K., Christensen, R. D., Widness, J. A., Mock, D. M., & Veng‐Pedersen, P. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.02.001 · Cited by 8
Specific targeting of cancer vaccines to antigen-presenting cells via an endogenous TLR2/6 ligand derived from cysteinyl-tRNA synthetase 1
Kim, H. Y., Cho, S., Kim, S. B., Song, E. C., Jung, W., Shin, Y., Suh, J. H., Choi, J., Yoon, I., Kim, U., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.07.014 · Cited by 8
Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming
Werner, R. M., & Soffa, A. N. (2023) · Toxicon X · doi:10.1016/j.toxcx.2023.100169 · Cited by 7
Penile cavernous sinusoids are Prox1-positive hybrid vessels
Schnabellehner, S., Kraft, M., Schoofs, H., Ortsäter, H., & Mäkinen, T. (2023) · Vascular Biology · doi:10.1530/vb-23-0014 · Cited by 7
Disposition of Biologics
Brady, K., & Webster, R. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-398339-8.00007-0 · Cited by 7
Beta-adrenergic glaucoma drugs reduce lymphatic clearance from the eye: A sequential photoacoustic imaging study
Hanna, J., Yücel, Y. H., Zhou, X., Kim, N., Irving, H. M., & Gupta, N. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108775 · Cited by 7
Pharmacokinetics of darbepoetin alfa after single, intravenous or subcutaneous administration in Japanese pediatric patients with chronic kidney disease
Uemura, O., Hattori, M., Hataya, H., Ito, S., Ito, N., & Akizawa, T. (2014) · Clinical and Experimental Nephrology · doi:10.1007/s10157-014-0936-7 · Cited by 7
Mechanism-based model of the pharmacokinetics of enfuvirtide, an HIV fusion inhibitor
Mohanty, U., & Dixit, N. M. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.12.017 · Cited by 7
Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia
Lauritzen, B., Lykkesfeldt, J., Djurup, R., Flodgaard, H. J., & Svendsen, O. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.01.004 · Cited by 7
Lymph node targeting for improved potency of cancer vaccine
Du, G., & Sun, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102983-1.00019-3 · Cited by 7
Use of Intraoperative Fluorescence to Enhance Robot-Assisted Radical Prostatectomy
Rajakumar, T., Yassin, M., Musbahi, O., Harris, E., López, J. F. J., Bryant, R. J., Tullis, I. D. C., Vojnovic, B., Hamdy, F. C., & Lamb, A. D. G. (2021) · Future Oncology · doi:10.2217/fon-2020-0370 · Cited by 7
Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
Tessier, N., Moawad, F., Amri, N., Brambilla, D., & Martel, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081200 · Cited by 7
Liposomes for Local Sustained Drug Release
Oussoren, C., Storm, G., Crommelin, D. J. A., & Senior, J. (2000) · CRC Press eBooks · doi:10.1201/b14421-8 · Cited by 7
State-of-the-art drug delivery system to target the lymphatics
Khaire, O., Mhaske, A. S., Prasad, A. G., Almalki, W. H., Srivastava, N., Kesharwani, P., & Shukla, R. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2309671 · Cited by 6
Formulation of Biologics Including Biopharmaceutical Considerations
Crommelin, D. J. A., Hawe, A., & Jiskoot, W. (2024) · Springer eBooks · doi:10.1007/978-3-031-30023-3_5 · Cited by 6
The Lymphatic Vascular System in Extracellular Vesicle-Mediated Tumor Progression
Lodha, P., Acari, A., Rieck, J., Hofmann, S., & Dieterich, L. C. (2024) · Cancers · doi:10.3390/cancers16234039 · Cited by 6
Eliminating Fc N-Linked Glycosylation and Its Impact on Dosing Consideration for a Transferrin Receptor Antibody-Erythropoietin Fusion Protein in Mice
Yang, J., Sun, J., Castellanos, D. M., Pardridge, W. M., & Sumbria, R. K. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00231 · Cited by 6
Vaccinelike and Prophylactic Treatments of EAE with Novel I-Domain Antigen Conjugates (IDAC): Targeting Multiple Antigenic Peptides to APC
Büyüktimkin, B., Manikwar, P., Kiptoo, P. K., Badawi, A. H., Stewart, J. M., & Siahaan, T. J. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300440x · Cited by 6
Impact of degradation in subcutaneous tissue and lymphatic fluid on absorption of Fc-fusion proteins following subcutaneous administration
Yokoyama, M., Suzuki, E., & Nakai, D. (2025) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2025.101500 · Cited by 5
Lymphatic metastasis in pancreatic cancer: from bedside to bench and back
Shi, H., Qin, C. Y., Zhao, Y., Zhao, B., Li, Z., Li, T., Huang, L., & Wang, W. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10297-9 · Cited by 7
Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids
Meibohm, B. (2024) · Springer eBooks · doi:10.1007/978-3-031-30023-3_6 · Cited by 5
Uncovering the interleukin‐12 pharmacokinetic desensitization mechanism and its consequences with mathematical modeling
DeBonis, J., Omid Veiseh, A., & Igoshin, O. A. (2024) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13258 · Cited by 5
Impact of moderate interval exercise versus supine rest on the pharmacokinetics and pharmacodynamic profiles of subcutaneously administered growth hormone in adult growth hormone deficient patients
Janukonyté, J., Parkner, T., Lauritzen, T., Christiansen, J. S., Frystyk, J., Pedersen, H. S., & Laursen, T. (2014) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2014.06.002 · Cited by 5
Pharmacokinetics of Protein- and Nucleotide-Based Drugs
Meibohm, B. (2004) · CRC Press eBooks · doi:10.1201/9780203492321.ch8 · Cited by 5
Pharmacokinetics of Therapeutic Proteins
Lu, Z., Sheng, J., & Zhang, W. (2017) · Methods and principles in medicinal chemistry · doi:10.1002/9783527699124.ch10 · Cited by 5
Hematopoietic growth factors: A promising future for use in bone marrow dysfunction
Mazza, J. J., Reding, D. J., & Plank, G. S. (1992) · Postgraduate Medicine · doi:10.1080/00325481.1992.11701380 · Cited by 5
Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins
Zhang, Y., & Meibohm, B. (2012) · Pharmaceutical biotechnology · doi:10.1002/9783527632909.ch14 · Cited by 5
Emerging trends in permeation-enhancing technologies for oral peptide delivery
Tao, J., Yang, J., Zhao, M., Zhu, Q., Chen, Z., & Qi, J. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.111170 · Cited by 4
Factors Influencing Monoclonal Antibody Pharmacokinetics Across Varying Immune Perturbations
DeBonis, J., Davis, A. E., Wang, Z., Fell, C., Diehl, M. R., Igoshin, O. A., & Omid Veiseh, A. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114191 · Cited by 4
High concentration subcutaneous biological drug products: challenges and advancements
Hu, G., Milewski, M., Krishnamachari, Y., Procopio, A. T., Wuelfing, W. P., Zhu, L., Mittal, S., Cheung, J. K., Givand, J. C., Burlage, R., et al. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115793 · Cited by 4
Large animal models for the assessment of snakebite envenoming therapies
Bénard-Valle, M., Ahmadi, S., Modahl, C. M., Neri-Castro, É., Alagón, A., Boyer, L., Ljungars, A., & Laustsen, A. H. (2026) · npj Drug Discovery. · doi:10.1038/s44386-026-00043-8 · Cited by 4
Breadth of Pharmacology Modeling: Fundamentals of Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling
Mager, D. E. (2025) · Handbook of experimental pharmacology · doi:10.1007/164_2025_746 · Cited by 4
Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats
McGill, M. R., Findley, D. L., Mazur, A., Yee, E. U., Allard, F. D., Powers, A., Coward, L. U., Blough, E. R., Gorman, G. S., & Hambuchen, M. D. (2022) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-022-00755-y · Cited by 4
Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia
Khadria, A., Paavola, C. D., Maslov, K., Brown‐Augsburger, P., Grealish, P. F., Lozano, E., Blankenship, R. L., Cao, R., Shi, J., Beals, J. M., et al. (2023) · Journal of Biomedical Optics · doi:10.1117/1.jbo.28.11.116002 · Cited by 4
Rose Bengal Labeled Bovine Serum Albumin for Protein Transport Imaging in Subcutaneous Tissues Using Computed Tomography and Fluorescence Microscopy
Hakim, M. H., Brindise, M. C., Ahmadzadegan, A., Buno, K., dos Santos, A., Cragg, K. R., Dou, Z., Ladisch, M. R., Ardekani, A. M., Vlachos, P. P., et al. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00240 · Cited by 4
Newly Developed Polyglycolic Acid Reinforcement Unified with Sodium Alginate to Prevent Adhesion
Morita, S., Takagi, T., Abe, R., Tsujimoto, H., Ozamoto, Y., Torii, H., & Hagiwara, A. (2018) · BioMed Research International · doi:10.1155/2018/4515949 · Cited by 4
Role of Lipid Nanocarriers in Lymphatic Targeting: Promises and Safety Considerations
Desai, J. L., & Thakkar, H. P. (2021) · Springer eBooks · doi:10.1007/978-981-33-4497-6_2 · Cited by 4

Authors: Supersaxo, A., Hein, W. R., & Steffen, H.
Affiliations: F. Hoffmann-La Roche AG (CH)
ORCID: Hein, Wayne R.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 1990-02
Volume: 7
Issue: 2
Pages: 167-169
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1023/a:1015880819328
OpenAlex: W1586699825
Cited by: 386
References: 14
Citations by year: 2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 29 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 9 · 2016: 11 · 2015: 20 · 2014: 10 · 2013: 20 · 2012: 25
FWCI: 5.21
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: lymphatic absorption, molecular weight, subcutaneous administration, water-soluble compounds, lymphatic drainage, 5-fluorodeoxyuridine, inulin, cytochrome c, interferon alfa-2a, sheep, lymphatic drug delivery
MeSH terms: Absorption, Animals, Chemistry, Physical, Female, Floxuridine, Injections, Subcutaneous, Insulin, Interferon Type I, Lymphatic System, Male, Molecular Weight, Recombinant Proteins, Sheep, Solubility, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks

Data sources