The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse
Abstract
The molecular regulation of telomere length has been well elucidated by a series of elegant studies over the past decade. More recently, experimental evidence has accrued that addresses the challenging question of if and how telomere length regulation may contribute to normal human aging or to human disease. Recent studies in mice have provided a mammalian precedent indicating that telomerase deficiency can lead to in vivo dysfunction, most probably as a consequence of progressive telomere shortening. In humans, the evidence that telomere shortening might lead to in vivo dysfunction is far less direct, although the recent description of telomerase deficiency and telomere shortening associated with the DKC syndrome is suggestive of such a link. Methodologies exist and continue to be developed that are increasingly capable of manipulating telomerase activity and telomere length in human cells. It remains to be determined whether scientifically rigorous and (equally important) medically ethical approaches will emerge to directly assess the ability of telomere length modulation to correct functional disorders of human cellular function ex vivo or more challenging still, in vivo.
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“The numbers and types of telomerase-expressing cells vary widely among species (17–19).”
From Aging, Cellular Senescence, and Cancer (2013) · cites this paper as [17]
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Cites
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“Further analysis of telomerase-deficient mice revealed that there were in fact more extensive phenotypic consequences of telomerase deficiency and telomere shortening than had initially been appreciated (60).”
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Metadata
- Authors
- Nan-PIng, W., & Hodes, R. J.
- ORCID
- Hodes, Richard J.
- Venue
- Journal of Clinical Immunology
- Published
- 2000-07
- Volume
- 20
- Issue
- 4
- Pages
- 257-267
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W1522182098
- Cited by
- 49
- References
- 63
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase, telomere maintenance, telomere shortening, telomerase deficiency, human aging, telomere length regulation, telomerase reactivation, cellular dysfunction
- MeSH terms
- Aging, Animals, Cell Transformation, Neoplastic, Chromosomes, DNA Replication, Endothelium, Vascular, Enzyme Induction, Fibroblasts, Hematopoietic Stem Cells, Humans, Infectious Mononucleosis, Leukocytes, Neoplasm Proteins, Neoplasms, Organ Specificity, HIV Infections, Lymphocyte Subsets, Genes, Tumor Suppressor, Telomere, Cellular Senescence, Mice, Knockout, Telomerase, Models, Animal, Genetic Diseases, Inborn, Mice
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