Telomere Dynamics in Mice and Humans
Open accessAbstract
Telomeres are ribonucleoprotein structures capping the end of every linear chromosome. In all vertebrates, they are composed of TTAGGG repeats coated with specific protecting proteins. Telomeres shorten with each mitotic cell division, but telomerase, a reverse transcriptase, elongate telomeres in very specific cells, such as embryonic and adult stem cells. Although telomere sequence is identical in mice and humans and telomeres serve the same role of protecting chromosomes and genetic information from damage and erosion in both species, abnormalities in telomere maintenance and in telomerase function do not coincide in phenotype in humans and mice. The telomeres of most laboratory mice are 5 to 10 times longer than in humans, but their lifespan is 30 times shorter. Complete absence of telomerase has little expression in phenotype over several generations in mice, whereas heterozygosity for telomerase mutations in humans is sufficient to result in organ regeneration defect and cancer development. Patients with telomerase deficiency and very short telomeres may develop aplastic anemia, pulmonary fibrosis, or cirrhosis, whereas telomerase-null murine models display only modest hematopoietic deficiency and develop emphysema when exposed to cigarette smoke. In summary, telomerase deficiency in both humans and mice accelerate telomere shortening, but its consequences in the different organs and in the organism diverge, mainly due to telomere length differences.
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Telomere length is commonly assessed in humans as an indicator of cellular age and replicative senescence, sometimes by flow cytometric methods, but this approach is limited in mice as telomeres are relatively long, meaning that telomere erosion may not be a major driver of immune aging.
“Telomere length is also commonly assessed in humans as an indicator of cellular age and replicative senescence, sometimes by flow cytometric methods, but this approach is limited in mice as telomeres are relatively long, meaning that telomere erosion may not be a major driver of immune aging [347].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [347]
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Mollica, L. R., Fleury, I., Bélisle, C., Provost, S., Roy, D.-C., & Busque, L. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp065 · Cited by 32 · see citing works
Anaemia is Associated with Shorter Leucocyte Telomere Length in Patients with Chronic Heart Failure
Wong, L. S. M., Huzen, J., van der Harst, P., de Boer, R. A., Codd, V., Westenbrink, B. D., Benus, G. F. J. D., Voors, A. A., van Gilst, W. H., Samani, N. J., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq007 · Cited by 25 · see citing works
Zhang, C., Tian, Y., Wang, Y., et al. (2013) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(13)60009-0 · Cited by 23 · see citing works
Telomere Length, Telomere-binding Proteins, and DNA Damage SignalingPreprint
Hemann, M. T., Hackett, J. A., IJpma, A. S., & Greider, C. W. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.275 · Cited by 18 · see citing works
Diamond Blackfan Anemia and Ribosome Biogenesis: Introduction
Ebert, B. L., & Lipton, J. M. M. (2011) · Seminars in Hematology · doi:10.1053/j.seminhematol.2011.01.003 · Cited by 6 · see citing works
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Jylhävä, J., Pedersen, N. L., & Hägg, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.046 · Cited by 1,240 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454 · see citing works
Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis
Naikawadi, R. P., Disayabutr, S., Mallavia, B., Donne, M. L., Green, G., La, J. L., Rock, J. R., Looney, M. R., & Wolters, P. J. (2016) · JCI Insight · doi:10.1172/jci.insight.86704 · Cited by 267 · see citing works
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Khristich, A. N., & Mirkin, S. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007678 · Cited by 289 · see citing works
Osterwald, S., Deeg, K. I., Chung, I., Parisotto, D., Wörz, S., Rohr, K., Erfle, H., & Rippe, K. (2015) · Journal of Cell Science · doi:10.1242/jcs.148296 · Cited by 92 · see citing works
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
Gao, Z., Daquinag, A. C., Fussell, C., Zhao, Z., Dai, Y., Rivera, A., Snyder, B. E., Eckel-Mahan, K. L., & Kolonin, M. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00320-4 · Cited by 92 · see citing works
Cell Therapy Strategies to Combat Immunosenescence
Stahl, E. C., & Brown, B. N. (2015) · Organogenesis · doi:10.1080/15476278.2015.1120046 · Cited by 73 · see citing works
Tanaka, H., Beam, M. J., & Caruana, K. (2014) · Neoplasia · doi:10.1016/j.neo.2014.08.009 · Cited by 19 · see citing works
Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression
Martínez‐González, K., Islas‐Hernández, A., Martínez‐Ezquerro, J. D., Bermúdez‐Rattoni, F., & Garcia‐delaTorre, P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14877 · Cited by 8 · see citing works
- Authors
- Calado, R. T., & Dumitriu, B.
- Affiliations
- Universidade de São Paulo (BR)
- National Institutes of Health (US)
- Venue
- Seminars in Hematology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 50
- Issue
- 2
- Pages
- 165-174
- ISSN
- 0037-1963 (ISSN-L)
- PMC
- PMC3742037
- OpenAlex
- W2009357228
- Cited by
- 214
- References
- 91
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 16 · 2023: 20 · 2022: 19 · 2021: 19 · 2020: 28 · 2019: 22 · 2018: 16 · 2017: 18 · 2016: 17 · 2015: 11 · 2014: 7
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Seminars in Hematology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 HL999999)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomeres, telomerase, telomere shortening, telomerase deficiency, telomere length, human-mouse comparison, telomere maintenance, aging, cancer, aplastic anemia, pulmonary fibrosis, emphysema
- MeSH terms
- Aging, Animals, Humans, Mutation, Neoplasms, Phenotype, Telomere, Telomerase, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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