The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Evidence for Autonomic Nervous System Imbalance in Women with Irritable Bowel Syndrome
Abstract
Autonomic nervous system function was assessed in women with and without irritable bowel syndrome using frequency domain measures of heart rate variability. Women were interviewed and placed into the irritable bowel syndrome (N = 25) group based on history of diagnosis and self-report of current gastrointestinal symptoms. Women in the control group denied a history of chronic gastrointestinal symptoms (N = 15). Women were followed for one menstrual cycle with a symptom diary, and during mid-luteal phase they wore a Holter 24-hr electrocardiograph monitor. Women with irritable bowel syndrome demonstrated significantly lower vagal tone as measured by the high frequency spectrum relative to control women. In addition, women with irritable bowel syndrome had a flattened 24-hr pattern of heart rate variability, with significantly lower levels of vagal tone during sleep. These results suggest that systemic sympathovagal balance may be shifted in a subset of women with irritable bowel syndrome.
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In the citing paper
“Nineteen studies compared IBS with HC (31–49), 9 compared IBD with HC (50–58), and 2 compared HRV across all 3 comparators (41,44).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [31]
In the citing paper
“HF was recorded in all studies, LF was recorded in 26 (96.8%) (31–47,50–58), and VLF was recorded in 6 (21.4%) (37,41,44,52,56,57).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [31]
In the citing paper
“HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.”
Citations
Cites
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Frequency domain measures of heart period variability and mortality after myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · Circulation · doi:10.1161/01.cir.85.1.164 · Cited by 1,712
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
A Patient Questionnaire to Identify Bowel Disease
Talley, N. J., Phillips, S. F., Melton, L. J., Wiltgen, C., & Zinsmeister, A. R. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-8-671 · Cited by 444
Heart rate variability. Frequency domain analysis.
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · PubMed · Cited by 300
Aggarwal, A., Cutts, T. F., Abell, T. L., Cardoso, S., Familoni, B., Bremer, J., & Karas, J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90753-6 · Cited by 297
Irritable bowel-type symptoms in HMO examinees
Longstreth, G. F., & Wolde-Tsadik, G. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303163 · Cited by 279
Heart rate variability in healthy subjects is related to age and gender
Jensen‐Urstad, K., Storck, N., BOUVIER, F., Ericson, M. O., LINDBLAND, L. E., & Jensen‐Urstad, M. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00142.x · Cited by 242
Őri, Z., Monir, G., Weiss, J., Sayhouni, X., & Singer, D. H. (1992) · Cardiology Clinics · doi:10.1016/s0733-8651(18)30231-5 · Cited by 234
Autonomic Vagal Nerve Dysfunction in Patients with Ulcerative Colitis
Lindgren, S. C., Stewénius, J., Sjölund, K., Lilja, B., & Sundkvist, G. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309096103 · Cited by 154
Autonomic dysfunction in gastrointestinal motility disorders
Bharucha, A. E., Camilleri, M., Low, P. A., & Zinsmeister, A. R. (1993) · Gut · doi:10.1136/gut.34.3.397 · Cited by 141
The sympathetic nervous system modulates perception and reflex responses to gut distention in humans
Iovino, P., Azpiroz, F., Domingo, E., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90439-5 · Cited by 135
Increased urine catecholamines and cortisol in women with irritable bowel syndrome.
Heitkemper, M. M., Jarrett, M. E., Cain, K. C., Shaver, J. L. F., Bond, E. F., Woods, N. F., & Walker, E. F. (1996) · PubMed · Cited by 127
Self-citationBockus, H. L., Bank, J., & Wilkinson, S. A. (1928) · The American Journal of the Medical Sciences · doi:10.1097/00000441-192812000-00006 · Cited by 106
ABNORMAL VAGAL FUNCTION IN IRRITABLE BOWEL SYNDROME
Smart, H. L. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91792-2 · Cited by 99
Cowan, M. J., Pike, K. C., & Burr, R. L. (1994) · Journal of Electrocardiology · doi:10.1016/s0022-0736(94)80037-5 · Cited by 68
Self-citationAutonomic Nervous System Function in Patients with Functional Abdominal Pain an Experimental Study
Jørgensen, L. S., Christiansen, P., Raundahl, U., Østgaard, S. E., Christensen, N. J., Fenger, M., & Flachs, H. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309096046 · Cited by 39
Research works printed but not linked: 1
- Lee KT, Rhee PL, Kim J, Koh KC, Paik SW, Rhee JC, Kim S: Assessment of autonomic tone over a 24-hour period in patients with irritable bowel syndrome. Gastroenterology 112:A773, 1997
Cited by
Sorted by citations
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666
Stress and the gastrointestinal tract
Bhatia, V., & Tandon, R. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03508.x · Cited by 496
V. Stress and irritable bowel syndrome
Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g519 · Cited by 413
Gender differences in irritable bowel syndrome
Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351
Self-citation
Metadata
- Authors
- Heitkemper, M., Burr, R. L., Jarrett, M., Hertig, V., Lustyk, M. K., & Bond, E. F.
- Affiliations
- University of Washington (US)
- Venue
- Digestive Diseases and Sciences
- Published
- 1998-09
- Volume
- 43
- Issue
- 9
- Pages
- 2093-2098
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W1488685077
- Cited by
- 117
- References
- 16
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 6 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 7
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Nursing Research (NR04101)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- irritable bowel syndrome, autonomic imbalance, heart rate variability, vagal tone, sympathovagal balance, women, menstrual cycle, luteal phase, sleep, gastrointestinal symptoms
- MeSH terms
- Adult, Autonomic Nervous System, Colonic Diseases, Functional, Female, Heart Rate, Humans, Middle Aged, Parasympathetic Nervous System, Vagus Nerve, Case-Control Studies
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