The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Purkinje Cell Size Is Reduced in Cerebellum of Patients with Autism
Open accessAbstract
1. The authors' goal was to compare the size and density of Purkinje cells in the cerebellum of subjects with and without autism. Blocks of cerebellum were dissected at autopsy from the brains of age, sex- and postmortem-intervaled (PMI) groups of autistic and normal control individuals (N = 5 per group). Frozen, unfixed blocks were sectioned and stained with 1% cresyl violet. 2. The linear, molecular, granular densities and cross-sectional area of Purkinje cells were measured using computer-assisted image analysis. The average cross-sectional areas of Purkinje cells of the patients with autism were smaller by 24% when compared to the normal subjects. Two of the five autistic subjects had mean Purkinje cell sizes that corresponded to greater than 50% reduction in size. There was a substantial effect size difference in Purkinje cell size (eta2 = 0.29) between control and autistic brains (F(1, 8) = 3.32, P = 0.106). No differences in Purkinje cell densities were observed between the two groups 3. These data indicate the possibility of Purkinje cell atrophy in autism with significant neurohistological heterogeneity among individuals diagnosed with this disorder.
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In the citing paper
“Reductions in size and number of Purkinje cells in cerebellar vermis in autism remain unresolved due to lack of stereological reports [311];”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [311]
In the citing paper
“The mean size of Purkinje cells in subjects with ASD is significantly smaller compared to controls [108, 380].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [108]
Citations
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Metadata
- Authors
- Fatemi, S. H., Halt, A. R., Realmuto, G., Earle, J., Kist, D. A., Thuras, P., & Merz, A.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Fatemi, S. Hossein
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2002-04
- Volume
- 22
- Issue
- 2
- Pages
- 171-175
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11533743
- OpenAlex
- W95237908
- Cited by
- 344
- References
- 6
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 15 · 2020: 14 · 2019: 17 · 2018: 13 · 2017: 11 · 2016: 18 · 2015: 23 · 2014: 17 · 2013: 24 · 2012: 17
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Research Foundation
- University of Minnesota
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, Purkinje cells, cerebellum, postmortem brain
- MeSH terms
- Adult, Atrophy, Autistic Disorder, Cell Count, Cerebellar Cortex, Humans, Male, Nervous System Malformations, Purkinje Cells, Cell Size
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