Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report
Abstract
As part of an autopsy research project, the brains of four autistic subjects were examined and compared with those of three comparison subjects without CNS pathology and one with phenytoin toxicity. The cerebellum was selected for initial investigation because pathognomonic symptoms and neurophysiological measures suggest that pathology may exist in the cerebellar-vestibular axis in certain patients. Total Purkinje cell counts were significantly lower in the cerebellar hemisphere and vermis of each autistic subject than in the comparison subjects.
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The cerebellum was the first brain region shown in the late 1980s to host neuroanatomical abnormalities in many autistic individuals.
“The cerebellum was the first brain region shown in the late 80’s to host neuroanatomical abnormalities in many autistic individuals [33, 228, 229].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [33]
The most frequently reported cerebellar anomalies in autism include smaller vermis volume, Purkinje cell numbers reduced by up to 50%, ectopic neurons in white matter, and patchy cytoarchitectonic ectopias in cerebellar cortex.
“The anomalies most frequently reported include a smaller vermis volume, Purkinje cell numbers reduced by up to 50%, ectopic neurons in the white matter, and patchy cytoarchitectonic ectopias in the cerebellar cortex [32, 33, 118, 228, 229].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [33]
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- Authors
- RITVO, E. R., Freeman, B. J., Scheibel, A. B., Duong, T., Robinson, H., Guthrie, D., & Ritvo, A.
- Venue
- American Journal of Psychiatry
- Published
- 1986-07
- Volume
- 143
- Issue
- 7
- Pages
- 862-866
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2154672996
- Cited by
- 590
- References
- 23
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 12 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 13 · 2014: 22 · 2013: 28 · 2012: 29
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (MCH927)
- National Institute of Mental Health (MH 31274)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-04612)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- autism spectrum disorder, Purkinje cells, cerebellum, postmortem brain examination, phenytoin toxicity, cerebellar vermis, cerebellar hemispheres
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Autopsy, Cell Count, Cerebellum, Child, Child, Preschool, Female, Humans, Male, Purkinje Cells
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