Cited by 344Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

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Purkinje Cell Size Is Reduced in Cerebellum of Patients with Autism

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Fatemi, S. Hossein, Halt, Amy R., Realmuto, George, Earle, Julie, Kist, David A., Thuras, Paul, Merz, Amelia·2002·Cellular and Molecular Neurobiology

DOI 10.1023/a:1019861721160PMC PMC11533743

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Abstract

1. The authors' goal was to compare the size and density of Purkinje cells in the cerebellum of subjects with and without autism. Blocks of cerebellum were dissected at autopsy from the brains of age, sex- and postmortem-intervaled (PMI) groups of autistic and normal control individuals (N = 5 per group). Frozen, unfixed blocks were sectioned and stained with 1% cresyl violet. 2. The linear, molecular, granular densities and cross-sectional area of Purkinje cells were measured using computer-assisted image analysis. The average cross-sectional areas of Purkinje cells of the patients with autism were smaller by 24% when compared to the normal subjects. Two of the five autistic subjects had mean Purkinje cell sizes that corresponded to greater than 50% reduction in size. There was a substantial effect size difference in Purkinje cell size (eta2 = 0.29) between control and autistic brains (F(1, 8) = 3.32, P = 0.106). No differences in Purkinje cell densities were observed between the two groups 3. These data indicate the possibility of Purkinje cell atrophy in autism with significant neurohistological heterogeneity among individuals diagnosed with this disorder.

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Authors: Fatemi, S. H., Halt, A. R., Realmuto, G., Earle, J., Kist, D. A., Thuras, P., & Merz, A.
Affiliations: University of Minnesota (US)
Corresponding author: Fatemi, S. Hossein
ORCID: Fatemi, S. Hossein
Thuras, Paul
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2002-04
Volume: 22
Issue: 2
Pages: 171-175
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1023/a:1019861721160
PMC: PMC11533743
OpenAlex: W95237908
Cited by: 344
References: 6
Citations by year: 2026: 13 · 2025: 18 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 15 · 2020: 14 · 2019: 17 · 2018: 13 · 2017: 11 · 2016: 18 · 2015: 23 · 2014: 17 · 2013: 24 · 2012: 17
FWCI: 3.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Autism Research Foundation
University of Minnesota
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: autism spectrum disorder, Purkinje cells, cerebellum, postmortem brain
MeSH terms: Adult, Atrophy, Autistic Disorder, Cell Count, Cerebellar Cortex, Humans, Male, Nervous System Malformations, Purkinje Cells, Cell Size

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Purkinje Cell Size Is Reduced in Cerebellum of Patients with Autism

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