The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol)
Abstract
The presence of poly(ethylene glycol) (PEG) at the surface of a liposomal carrier has been clearly shown to extend the circulation lifetime of the vehicle. To this point, the extended circulation lifetime that the polymer affords has been attributed to the reduction or prevention of protein adsorption. However, there is little evidence that the presence of PEG at the surface of a vehicle actually reduces total serum protein binding. In this review we examine all aspects of PEG in order to gain a better understanding of how the polymer fulfills its biological role. The physical and chemical properties of the polymer are explored and compared to properties of other hydrophilic polymers. An evidence based assessment of several in vitro protein binding studies as well as in vivo pharmacokinetics studies involving PEG is included. The ability of PEG to prevent the self-aggregation of liposomes is considered as a possible means by which it extends circulation longevity. Also, a “dysopsonization” phenomenon where PEG actually promotes binding of certain proteins that then mask the vehicle is discussed.
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Cites
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Cited by
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951
Challenges in Development of Nanoparticle-Based Therapeutics
Desai, N. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9339-4 · Cited by 1,173
Targeting nanoparticles to cancer
Wang, M., & Thanou, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.03.005 · Cited by 931
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come
Yingchoncharoen, P., Kalinowski, D. S., & Richardson, D. R. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012070 · Cited by 744
The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
Abu Lila, A. S., Kiwada, H., & Ishida, T. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.026 · Cited by 721
Metadata
- Authors
- Allen, C., Dos Santos, N., Gallagher, R., Chiu, G. N. C., Shu, Y., Li, W. M., Johnstone, S. A., Janoff, A. S., Mayer, L. D., Webb, M. S., & Bally, M. B.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2002-04-01
- Volume
- 22
- Issue
- 2
- Pages
- 225-250
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W1796518311
- Cited by
- 388
- References
- 48
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Allen, C., Dos Santos, N., Gallagher, R., Chiu, G. N. C., Shu, Y., Li, W. M., Johnstone, S. A., Janoff, A. S., Mayer, L. D., Webb, M. S., & Bally, M. B. (2002). Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol). Bioscience Reports. https://doi.org/10.1023/a%3A1020186505848
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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